{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T19:07:09Z","timestamp":1789326429898,"version":"build-2803163510"},"reference-count":38,"publisher":"Consilium Medicum","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Of undoubted interest is the search for new drugs comparable in effectiveness to nonsteroidal anti-inflammatory drugs (NSAIDs), but with a safer application profile. NSAIDs are characterized by a good analgesic effect due to the modulation of prostaglandin metabolism by inhibition of cyclooxygenase-2. One of the promising directions of pharmacotherapy of degenerative-dystrophic joint lesions is the use of symptom-modifying drugs of delayed action, which include chondroitin sulfate (CS). CS has antiresorptive activity, anti-inflammatory and anti-inflamaging effects. In addition to the direct effect on pain syndrome severity, he also have a modulating level effect of systemic inflammation of cartilage tissue. According to experts of international and Russian societies, pharmaceutical prescription-quality CS is a basic part of the treatment of osteoarthritis. One of the advantages of CS over NSAIDs is the preservation of the effect for 24 months after the treatment. Against the background of the use of CS, it is possible to reduce the dose or completely cancel NSAIDs, which helps to reduce the frequency of adverse events associated with their intake. CS has a favorable safety profile, which is important for elderly patients and those with comorbid diseases (cardioprotective effects). CS drugs can be administered per orally, intramuscularly, intra-articularly and in combination with different administration methods. Several clinical trials of CS (Chondrogard), including randomized, were conducted in Russia. The Russia Health Ministry approved the appointment of parenteral CS in clinical guidelines: Chronic pain in elderly and senile patients (2020), Falls in elderly and senile patients(2020), \"Knee osteoarthritis\" (2021), \"Hip osteoarthritis\" (2021).<\/jats:p>","DOI":"10.26442\/00403660.2021.12.201241","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T14:37:11Z","timestamp":1642603031000},"page":"1551-1555","source":"Crossref","is-referenced-by-count":3,"title":["Chondroitin sulfate in therapy osteoarthritis chronic pain patients according to actual clinical recommendations"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-0730","authenticated-orcid":false,"given":"Olga A.","family":"Shavlovskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32230-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1679"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102616"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.09.008"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.011742"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212662"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.14412\/2074-2711-2019-1-117-124"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20997"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.04.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01423-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24131"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-017-0861-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206792"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd005614.pub2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-00921-w"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.01.055"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216655"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213826"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2020.07.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.10.006"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253932"},{"key":"ref24","unstructured":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u043e\u0441\u0442\u0435\u043e\u0430\u0440\u0442\u0440\u043e\u0437\u0430. \u041e\u0431\u0449\u0435\u0440\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0430\u044f \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u0430\u044f \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u044f \u00ab\u0410\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u043e\u0432 \u0420\u043e\u0441\u0441\u0438\u0438\u00bb. 2013. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/rheumatolog.ru\/experts\/klinicheskie-rekomendacii. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Federal clinical guidelines for the diagnosis and treatment of osteoarthritis. All-Russian public organization \u201cAssociation of rheumatologists of Russia\u201d. 2013. Available at: https:\/\/rheumatolog.ru\/experts\/klinicheskie-rekomendacii. Accessed: 10.10.2021 (in Russian)]."},{"key":"ref25","unstructured":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u041c\u0417 \u0420\u0424 \u00ab\u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u044c \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u043e\u0436\u0438\u043b\u043e\u0433\u043e \u0438 \u0441\u0442\u0430\u0440\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430\u00bb. 2020. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/cr.rosminzdrav.ru\/#!\/recomend\/1033. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Chronic pain in elderly and senile patients. Russian Federation Health Ministry Clinical recommendations. 2020. Available at: https:\/\/cr.rosminzdrav.ru\/#!\/recomend\/1033. Accessed: 10.10.2021 (in Russian)]."},{"key":"ref26","unstructured":"\u041f\u0430\u0434\u0435\u043d\u0438\u044f \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u043e\u0436\u0438\u043b\u043e\u0433\u043e \u0438 \u0441\u0442\u0430\u0440\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432\u0430 \u0420\u043e\u0441\u0441\u0438\u0438. 2020. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/cr.rosminzdrav.ru\/#!\/recomend\/1030. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Falls in elderly and senile patients. Federation Health Ministry Clinical recommendations. 2020. Available at: https:\/\/ cr.rosminzdrav.ru\/#!\/recomend\/1030. Accessed: 10.10.2021 (in Russian)]."},{"key":"ref27","unstructured":"\u0413\u043e\u043d\u0430\u0440\u0442\u0440\u043e\u0437. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432\u0430 \u0420\u043e\u0441\u0441\u0438\u0438. 2021. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/cr.minzdrav.gov.ru\/recomend\/667_1. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Gonarthrosis. Russian Federation Health Ministry Clinical recommendations. 2021. Available at: https:\/\/cr.minzdrav.gov.ru\/recomend\/667_1. Accessed: 10.10.2021 (in Russian)]."},{"key":"ref28","unstructured":"\u041a\u043e\u043a\u0441\u0430\u0440\u0442\u0440\u043e\u0437. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432\u0430 \u0420\u043e\u0441\u0441\u0438\u0438. 2021. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/cr.minzdrav.gov.ru\/recomend\/666_1. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Coxarthrosis. Russian Federation Health Ministry Clinical recommendations. 2021. Available at: https:\/\/cr.minzdrav.gov.ru\/recomend\/667_1. Accessed: 10.10.2021 (in Russian)]."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.17749\/2070-4909\/farmakoekonomika.2020.066"},{"key":"ref30","unstructured":"\u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432\u0430 \u041b.\u0418., \u0410\u043d\u0438\u043a\u0438\u043d \u0421.\u0413., \u0417\u0430\u0439\u0446\u0435\u0432\u0430 \u0415.\u041c., \u0438 \u0434\u0440. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438, \u043f\u0435\u0440\u0435\u043d\u043e\u0441\u0438\u043c\u043e\u0441\u0442\u0438 \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u0425\u043e\u043d\u0434\u0440\u043e\u0433\u0430\u0440\u0434 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043e\u0441\u0442\u0435\u043e\u0430\u0440\u0442\u0440\u043e\u0437\u043e\u043c. \u0420\u041c\u0416. 2013;21(32):1624-27. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/elibrary.ru\/item.asp?id=21109420. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Alekseeva LI, Anikin SG, Zaitseva EM, et al. Investigation of the efficacy, tolerability and safety of the drug Chondrogard in patients with osteoarthritis. Available at: https:\/\/elibrary.ru\/item.asp?id=21109420. Accessed: 10.10.2021 (in Russian)]."},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.14412\/2074-2711-2021-4-123-129"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.17749\/2070-4909\/farmakoekonomika.2021.083"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.14412\/1996-7012-2021-1-136-143"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"\u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432\u0430 \u041b.\u0418., \u0428\u0430\u0440\u0430\u043f\u043e\u0432\u0430 \u0415.\u041f., \u041a\u0430\u0448\u0435\u0432\u0430\u0440\u043e\u0432\u0430 \u041d.\u0413., \u0438 \u0434\u0440. \u0421\u0440\u0430\u0432\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u0425\u043e\u043d\u0434\u0440\u043e\u0433\u0430\u0440\u0434\u00ae \u043f\u0440\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u043c (\u0432\u043d\u0443\u0442\u0440\u0438\u0441\u0443\u0441\u0442\u0430\u0432\u043d\u043e\u0435 \u0438 \u0432\u043d\u0443\u0442\u0440\u0438\u043c\u044b\u0448\u0435\u0447\u043d\u043e\u0435) \u0438 \u0432\u043d\u0443\u0442\u0440\u0438\u043c\u044b\u0448\u0435\u0447\u043d\u043e\u043c \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0438 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u043e\u0441\u0442\u0435\u043e\u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c \u043a\u043e\u043b\u0435\u043d\u043d\u044b\u0445 \u0441\u0443\u0441\u0442\u0430\u0432\u043e\u0432. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2018;12(2):44-9 [Alekseeva LI, Sharapova EP, Kashevarova NG, et al. Comparative study of the efficacy and safety of Chondroguard\u00ae during its combined (intra-articular and intramuscular) and intramuscular injection in patients with knee osteoarthritis. Modern Rheumatology Journal. 2018;12(2):44-9 (in Russian)]. DOI:10\/14412\/1996-7012-2018-2-44-49","DOI":"10.14412\/1996-7012-2018-2-44-49"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2020.05.000631"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.14412\/1996-7012-2021-4-120-125"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.17749\/2070-4909.2019.12.4.255-266"},{"key":"ref38","unstructured":"\u041b\u0438\u043b\u0430 \u0410.\u041c., \u0422\u043a\u0430\u0447\u0435\u0432\u0430 \u041e.\u041d., \u041d\u0430\u0443\u043c\u043e\u0432 \u0410.\u0412., \u0438 \u0434\u0440. \u041c\u0435\u0441\u0442\u043e \u0438 \u0440\u043e\u043b\u044c \u043f\u0430\u0440\u0435\u043d\u0442\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0439 \u0444\u043e\u0440\u043c\u044b \u0445\u043e\u043d\u0434\u0440\u043e\u0438\u0442\u0438\u043d\u0430 \u0441\u0443\u043b\u044c\u0444\u0430\u0442\u0430 \u0432 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043e\u0441\u0442\u0435\u043e\u0430\u0440\u0442\u0440\u0438\u0442\u0430: \u043c\u0443\u043b\u044c\u0442\u0438\u0434\u0438\u0441\u0446\u0438\u043f\u043b\u0438\u043d\u0430\u0440\u043d\u044b\u0439 \u043a\u043e\u043d\u0441\u0435\u043d\u0441\u0443\u0441. \u0420\u041c\u0416. 2021;29(6):68-74. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/elibrary.ru\/item.asp?id=46433906. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 10.10.2021 [Lila AM, Tkacheva ON, Naumov AV, et al. Place and role of the parenteral form of chondroitin sulfate in the treatment of osteoarthritis: multidisciplinary consensus. RMJ. 2021;29(6):68-74. Available at: https:\/\/elibrary.ru\/item.asp?id=46433906. Accessed: 10.10.2021 (in Russian)]."}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/96510\/70762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/96510\/70762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:19:13Z","timestamp":1643023153000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/96510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.12.201241","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}