{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:33:32Z","timestamp":1782545612711,"version":"3.54.5"},"reference-count":14,"publisher":"Consilium Medicum","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Background. Biliary sludge (BS) refers to the pre-stone stage of gallstone disease. Timely treatment of this condition with ursodeoxycholic acid (UDCA) drugs helps prevent the progression of the disease. However, not all drugs used in practice are equally effective in relieving clinical manifestations, resolving sludge according to ultrasound results and tolerance.\r\nAim. To evaluate the therapeutic efficacy of the drug Ursofalk in comparison with other UDCA drugs used for the treatment of BS.\r\nMaterials and methods. We examined 105 people with different types of BS identified during ultrasound examination (US); they were divided into 2 groups depending on the UDCA drug taken. In patients, the dynamics of clinical manifestations was assessed using a questionnaire, as well as the dynamics of the ultrasound picture while taking UDCA.\r\nResults. Statistical analysis showed that Ursofalk significantly better relieves biliary pain (p=0.025) and biliary dyspepsia (p=0.039), pain regression occurs faster (p=0.01)  in 21 days. It also has a better tolerance in 94.34% of cases compared to other drugs  67.31% (p=0.017). Ursofalk has a greater effect on the regression of BS according to ultrasound results after 3 months (p=0.022) and 6 months (p=0.016).\r\nConclusion. The drug studied by us demonstrated high efficiency in relation to patients with BS, while there were minimal side effects, which led to a better tolerability of therapy.<\/jats:p>","DOI":"10.26442\/00403660.2021.12.201250","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T14:37:11Z","timestamp":1642603031000},"page":"1477-1481","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of therapeutic efficiency of various drugs of ursodeoxycholic acid in the treatment of biliary sludge"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-482X","authenticated-orcid":false,"given":"Albina R.","family":"Isanbaeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-8184","authenticated-orcid":false,"given":"Giulnar M.","family":"Sakhautdinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref1","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0410.\u0410. \u0411\u043e\u043b\u0435\u0437\u043d\u0438 \u0436\u0435\u043b\u0447\u043d\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f \u0438 \u0436\u0435\u043b\u0447\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439. \u0420\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u0434\u043b\u044f \u0432\u0440\u0430\u0447\u0435\u0439. 2-\u0435 \u0438\u0437\u0434., \u043f\u0435\u0440\u0435\u0440\u0430\u0431. \u0438 \u0434\u043e\u043f. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0435 \u0430\u0433\u0435\u043d\u0442\u0441\u0442\u0432\u043e, 2011 [Ilchenko AA. Bolezni zhelchnogo puzyria i zhelchnykh putei. Rukovodstvo dlia vrachei. 2-e izd., pererab. i dop. Moscow: Meditsinskoe informatsionnoe agentstvo, 2011 (in Russian)]."},{"key":"ref2","unstructured":"\u0412\u0438\u0445\u0440\u043e\u0432\u0430 T. \u0411\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436 \u0438 \u0435\u0433\u043e \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435. \u0414\u0438\u0441. \u2026 \u043a\u0430\u043d\u0434. \u043c\u0435\u0434. \u043d\u0430\u0443\u043a. \u041c., 2003 [Vihrova T. Biliarnyi sladzh i ego klinicheskoe znachenie. Dis. \u2026 kand. med. nauk. Moscow, 2003 (in Russian)]."},{"key":"ref3","unstructured":"\u041c\u0435\u0445\u0442\u0438\u0435\u0432 \u0421.\u041d., \u0413\u0440\u0438\u043d\u0435\u0432\u0438\u0447 \u0412.\u0411., \u041a\u0440\u0430\u0432\u0447\u0443\u043a \u042e.\u0410., \u0411\u043e\u0433\u0434\u0430\u043d\u043e\u0432 \u0420.\u041d. \u0411\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436: \u043d\u0435\u0440\u0435\u0448\u0435\u043d\u043d\u044b\u0435 \u0432\u043e\u043f\u0440\u043e\u0441\u044b. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2007;6:24-8 [Mekhtiev SN, Grinevich VB, Kravchuk YuA, Bogdanov RN. Biliarnyi sladzh: nereshennye voprosy. Lechaschi Vrach. 2007;6:24-8 (in Russian)]."},{"key":"ref4","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0410.\u0410. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0439 \u0432\u0437\u0433\u043b\u044f\u0434 \u043d\u0430 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0443 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0433\u043e \u0441\u043b\u0430\u0434\u0436\u0430. \u0420\u041c\u0416. \u0411\u043e\u043b\u0435\u0437\u043d\u0438 \u043e\u0440\u0433\u0430\u043d\u043e\u0432 \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f. 2010;28:1707-13 [Il'chenko AA. Sovremennyi vzgliad na problemu biliarnogo sladzha. RMZH. Bolezni organov pishchevareniya. 2010;28:1707-13 (in Russian)]."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2021.02.200638"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.22416\/1382-4376-2018-28-3-63-80"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"ref8","unstructured":"\u0425\u043b\u044b\u043d\u043e\u0432 \u0418.\u0411., \u0410\u043a\u0438\u043c\u0435\u043d\u043a\u043e \u0420.\u0418., \u0413\u0443\u0440\u0438\u043a\u043e\u0432\u0430 \u0418.\u0410., \u0438 \u0434\u0440. \u0411\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436: \u043e\u043f\u044b\u0442 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0432 \u0440\u0435\u0430\u043b\u044c\u043d\u043e\u0439 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2019;4:80-83 [Hlynov IB, Akimenko RI, Gurikova IA, et al. Biliary sludge: therapeutic experience in the real clinical practice. Lechaschi Vrach. 2019;4:80-3 (in Russian)]."},{"key":"ref9","unstructured":"\u041c\u0438\u043d\u0443\u0448\u043a\u0438\u043d \u041e.\u041d., \u0411\u0443\u0440\u0434\u0438\u043d\u0430 \u0415.\u0413., \u041d\u043e\u0432\u043e\u0436\u0435\u043d\u043e\u0432\u0430 \u0415.\u0412., \u0438 \u0434\u0440. \u0411\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0432 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u043f\u043e\u043b\u0438\u043a\u043b\u0438\u043d\u0438\u043a\u0438. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2013;9:14-20 [Minushkin ON, Burdina EG, Novozhenova EV, et al. Biliarnyj sladzh, diagnostika i lechenie v usloviyah polikliniki. Eksperimental'naya i klinicheskaya gastroenterologiya. 2013;9:14-20 (in Russian)]."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01792.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199630050-00002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2021.02.200638"},{"key":"ref13","unstructured":"\u0422\u043e\u043f\u0447\u0438\u0439 \u041d.\u0412., \u0422\u043e\u043f\u043e\u0440\u043a\u043e\u0432 \u0410.\u0421. \u0425\u043e\u043b\u0435\u043b\u0438\u0442\u0438\u0430\u0437 \u0438 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436: \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. 2011;7:36-45 [Topchij NV, Toporkov AS. Kholelitiaz i biliarnyi sladzh: sovremennye metody diagnostiki i lecheniia. Effektivnaia farmakoterapiia. 2011;7:36-45 (in Russian)]."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2020.08.000700"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/96426\/70652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/96426\/70652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:16:44Z","timestamp":1643023004000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/96426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":14,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.12.201250","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}