{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:33:58Z","timestamp":1740180838047,"version":"3.37.3"},"reference-count":24,"publisher":"Consilium Medicum","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To analyze the features of drugs provision for special groups of treatment-nave HIV-infected patients initiating antiretroviral treatment with fixed dose combination (FDC) for once-daily single-tablet regimen, in Russian healthcare setting. Materials and methods. We studied the regulatory legal documents governing the provision of antiretroviral drugs in Russia and analyzed the Russian Program of State Guarantees to determine the inclusion of the investigated FDCs in the lists of regional benefits, as well as regional and federal procurement of these drugs in 2020 and 2021. We compared costs of first line therapy for special groups using FDCs regimens per year in case of regional purchases or centralized purchases. Results. It was show that doravirin\/tenofovir\/lamivudine was the least expensive in 2020 and in 2021 among new FDCs form drugs. Worth 325.8 and 323.9 thousand rubles. per patient per year. \u0422he most expensive was bictegravir\/tenofovir alafenamide\/emtricitabine (401.6 and 439.9 thousand rubles, respectively). In case of Ministry of Health centralized purchases, the costs of new FDCs (doravirin\/tenofovir\/lamivudine and bictegravir\/tenofovir alafenamide\/emtricitabine), included in Vital and Essential drug list (VEDL) in 2022, will amount to 151,2 and 191.4 thousand rubles respectively, which is 52.9% and 40.4% lower than the cost per course of rilpivirine\/tenofovir\/emtricitabine. Conclusion. The inclusion of new effective and economical FDCs the whole scheme in one tablet once-daily in VEDL, expands the possibilities of simplify and effective first-line therapy for special groups of HIV-infected patients, as well as reduce the financial burden on the Program of State Guarantees budget and increases treatment coverage. All of this corresponds to the goals of the State Strategy to Combat the Spread of HIV in Russian Federation.<\/jats:p>","DOI":"10.26442\/00403660.2021.12.201296","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T14:37:11Z","timestamp":1642603031000},"page":"1516-1521","source":"Crossref","is-referenced-by-count":0,"title":["The analysis of the availability of fixed-dose combinations in antiretroviral therapy for HIV infection in the Russian Federation"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4173-2027","authenticated-orcid":false,"given":"Elena A.","family":"Pyadushkina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-9936","authenticated-orcid":false,"given":"Elena V.","family":"Derkach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. 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Available at: https:\/\/www.garant.ru\/products\/ipo\/prime\/doc\/400033496\/#1000. Accessed: 02.11.2021 (in Russian)]."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u00ab\u0412\u0418\u0427-\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445\u00bb. ID: 79. 2020. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/cr.minzdrav.gov.ru\/schema\/79_1. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 21.09.2021 [Klinicheskie rekomendatsii \u201cVICh-infektsiia u vzroslykh\u201d. ID: 79. 2020. Available at: https:\/\/cr.minzdrav.gov.ru\/schema\/79_1. 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Available at: http:\/\/grls.rosminzdrav.ru\/pricelims.aspx. Accessed: 24.09.2021 (in Russian)]."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"\u041d\u0430\u043b\u043e\u0433\u043e\u0432\u044b\u0439 \u043a\u043e\u0434\u0435\u043a\u0441 \u0420\u0424. \u0421\u0442\u0430\u0442\u044c\u044f 164. \u041d\u0430\u043b\u043e\u0433\u043e\u0432\u044b\u0435 \u0441\u0442\u0430\u0432\u043a\u0438. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: http:\/\/nalogovyykodeks.ru\/statya-164.html. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 16.07.2021 [Nalogovyi kodeks RF. Stat'ia 164. Nalogovye stavki. Available at: http:\/\/nalogovyykodeks.ru\/statya-164.html. Accessed: 16.07.2021 (in Russian)].","DOI":"10.1109\/MVT.2021.3094082"},{"key":"ref12","unstructured":"\u041f\u0440\u043e\u0442\u043e\u043a\u043e\u043b \u0437\u0430\u0441\u0435\u0434\u0430\u043d\u0438\u044f \u043a\u043e\u043c\u0438\u0441\u0441\u0438\u0438 \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u0424 \u043f\u043e \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044e \u043f\u0435\u0440\u0435\u0447\u043d\u0435\u0439 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0438 \u043c\u0438\u043d\u0438\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0430\u0441\u0441\u043e\u0440\u0442\u0438\u043c\u0435\u043d\u0442\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u0434\u043b\u044f \u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438 \u043e\u0442 22 \u0430\u043f\u0440\u0435\u043b\u044f 2021 \u0433. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/static-0.minzdrav.gov.ru\/system\/attachments\/attaches\/000\/055\/771\/original\/\u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b_22.04.2021.pdf?1621011114. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 17.10.2021 [Protokol Zasedaniia komissii Ministerstva zdravookhraneniia RF po formirovaniiu perechnei lekarstvennykh preparatov dlia meditsinskogo primeneniia i minimal'nogo assortimenta lekarstvennykh preparatov, neobkhodimykh dlia okazaniia meditsinskoi pomoshchi ot 22 aprelia 2021 g. Available at: https:\/\/static-0.minzdrav.gov.ru\/system\/attachments\/attaches\/000\/055\/771\/original\/protokol_22.04.2021.pdf?1621011114. Accessed: 17.10.2021 (in Russian)]."},{"key":"ref13","unstructured":"\u0413\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u0440\u0435\u0435\u0441\u0442\u0440 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/grls.rosminzdrav.ru\/grls.aspx. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 04.11.2021 [Gosudarstvennyi reestr lekarstvennykh sredstv. Available at: https:\/\/grls.rosminzdrav.ru\/grls.aspx. Accessed: 04.11.2021 (in Russian)]."},{"key":"ref14","unstructured":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0444\u043e\u043d\u0434 \u043e\u0431\u044f\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u0441\u0442\u0440\u0430\u0445\u043e\u0432\u0430\u043d\u0438\u044f. \u0421\u0438\u0441\u0442\u0435\u043c\u0430 \u041e\u041c\u0421 \u0420\u0424. \u0422\u0435\u0440\u0440\u0438\u0442\u043e\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0435 \u0444\u043e\u043d\u0434\u044b. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: http:\/\/www.ffoms.gov.ru\/system-oms\/territorial-funds\/tsentralnyy-federalnyy-okrug\/. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 28.10.2021 [Federal'nyi fond obiazatel'nogo meditsinskogo strakhovaniia. Sistema OMS RF. Territorial'nye fondy. Available at: http:\/\/www.ffoms.gov.ru\/system-oms\/territorial-funds\/tsentralnyy-federalnyy-okrug\/. Accessed: 28.10.2021 (in Russian)]."},{"key":"ref15","unstructured":"\u041f\u0440\u0438\u043a\u0430\u0437 \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u0424 \u043e\u0442 20 \u043d\u043e\u044f\u0431\u0440\u044f 2018 \u0433. \u2116799\u043d \u00ab\u041e\u0431 \u0443\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u0438 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u0430 \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u043a\u043e-\u0441\u0430\u043d\u0438\u0442\u0430\u0440\u043d\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u043c \u043f\u0440\u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u043e\u0439 \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0438\u043c\u043c\u0443\u043d\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 (\u0412\u0418\u0427) (\u043e\u0441\u043e\u0431\u044b\u0435 \u0441\u043b\u0443\u0447\u0430\u0438 \u0430\u043d\u0442\u0438\u0440\u0435\u0442\u0440\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u0435\u0440\u0432\u043e\u0433\u043e \u0440\u044f\u0434\u0430)\u00bb. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/itpcru.org\/2019\/02\/20\/novye-standarty-pervichnoj-mediko-sanitarnoj-pomoshhi-vzroslym-pri-bolezni-vyzvannoj-vich\/. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 30.10.2021 [Prikaz Ministerstva zdravookhraneniia RF ot 20 noiabria 2018 g. \u2116799n \u201cOb utverzhdenii standarta pervichnoi mediko-sanitarnoi pomoshchi vzroslym pri bolezni, vyzvannoi virusom immunodefitsita cheloveka (VICh) (osobye sluchai antiretrovirusnoi terapii pervogo riada)\u201d. Available at: https:\/\/itpcru.org\/2019\/02\/20\/novye-standarty-pervichnoj-mediko-sanitarnoj-pomoshhi-vzroslym-pri-bolezni-vyzvannoj-vich\/. Accessed: 30.10.2021 (in Russian)]."},{"key":"ref16","unstructured":"\u041f\u0440\u043e\u0435\u043a\u0442 \u043f\u0440\u0438\u043a\u0430\u0437\u0430 \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438 \u00ab\u041e\u0431 \u0443\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u0438 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u043c \u043f\u0440\u0438 \u0412\u0418\u0427-\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 (\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438 \u0434\u0438\u0441\u043f\u0430\u043d\u0441\u0435\u0440\u043d\u043e\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0435)\u00bb (\u041f\u0440\u043e\u0435\u043a\u0442). \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/regulation.gov.ru\/projects#npa=115026. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 02.11.2021 [Proekt prikaza Ministerstva zdravookhraneniia Rossiiskoi Federatsii \u201cOb utverzhdenii standarta meditsinskoi pomoshchi vzroslym pri VICh-infektsii (diagnostika, lechenie i dispansernoe nabliudenie)\u201d (Proekt). Available at: https:\/\/regulation.gov.ru\/projects#npa=115026. Accessed: 02.11.2021 (in Russian)]."},{"key":"ref17","unstructured":"\u0420\u0430\u0441\u043f\u043e\u0440\u044f\u0436\u0435\u043d\u0438\u0435 \u041f\u0440\u0430\u0432\u0438\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0420\u0424 \u043e\u0442 12.10.2019 \u21162406-\u0440 (\u0440\u0435\u0434. \u043e\u0442 23.11.2020) \u00ab\u041e\u0431 \u0443\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u0438 \u043f\u0435\u0440\u0435\u0447\u043d\u044f \u0436\u0438\u0437\u043d\u0435\u043d\u043d\u043e \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u0438 \u0432\u0430\u0436\u043d\u0435\u0439\u0448\u0438\u0445 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432, \u0430 \u0442\u0430\u043a\u0436\u0435 \u043f\u0435\u0440\u0435\u0447\u043d\u0435\u0439 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0438 \u043c\u0438\u043d\u0438\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0430\u0441\u0441\u043e\u0440\u0442\u0438\u043c\u0435\u043d\u0442\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432, \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u0434\u043b\u044f \u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438\u00bb (\u0441 \u0438\u0437\u043c. \u0438 \u0434\u043e\u043f., \u0432\u0441\u0442\u0443\u043f. \u0432 \u0441\u0438\u043b\u0443 \u0441 01.01.2021) [Rasporiazhenie Pravitel'stva RF ot 12.10.2019 \u21162406-r (red. ot 23.11.2020) \u201cOb utverzhdenii perechnia zhiznenno neobkhodimykh i vazhneishikh lekarstvennykh preparatov, a takzhe perechnei lekarstvennykh preparatov dlia meditsinskogo primeneniia i minimal'nogo assortimenta lekarstvennykh preparatov, neobkhodimykh dlia okazaniia meditsinskoi pomoshchi\u201d (s izm. i dop., vstup. v silu s 01.01.2021) (in Russian)]."},{"key":"ref18","unstructured":"\u041f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0435 \u041f\u0440\u0430\u0432\u0438\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0420\u0424 \u043e\u0442 28.12.2020 \u21162299 \u00ab\u041e \u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0439 \u0431\u0435\u0441\u043f\u043b\u0430\u0442\u043d\u043e\u0433\u043e \u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f \u0433\u0440\u0430\u0436\u0434\u0430\u043d\u0430\u043c \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438 \u043d\u0430 2021 \u0433\u043e\u0434 \u0438 \u043d\u0430 \u043f\u043b\u0430\u043d\u043e\u0432\u044b\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 2022 \u0438 2023 \u0433\u043e\u0434\u043e\u0432\u00bb (\u0432 \u0440\u0435\u0434. \u041f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0439 \u041f\u0440\u0430\u0432\u0438\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0420\u0424 \u043e\u0442 11.03.2021 \u2116354, \u043e\u0442 18.06.2021 \u2116927, \u043e\u0442 28.08.2021 \u21161436) [Postanovlenie Pravitel'stva RF ot 28.12.2020 \u21162299 \u201cO programme gosudarstvennykh garantii besplatnogo okazaniia grazhdanam meditsinskoi pomoshchi na 2021 god i na planovyi period 2022 i 2023 godov\u201d (v red. Postanovlenii Pravitel'stva RF ot 11.03.2021 \u2116354, ot 18.06.2021 \u2116927, ot 28.08.2021 \u21161436) (in Russian)]."},{"key":"ref19","unstructured":"\u041f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0435 \u041f\u0440\u0430\u0432\u0438\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0420\u0424 \u043e\u0442 28.12.2016 \u21161512 \u00ab\u041e\u0431 \u0443\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u0438 \u041f\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u044f \u043e\u0431 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0438 \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0435\u043d\u0438\u044f \u043b\u0438\u0446, \u0438\u043d\u0444\u0438\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0432\u0438\u0440\u0443\u0441\u043e\u043c \u0438\u043c\u043c\u0443\u043d\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430, \u0432 \u0442\u043e\u043c \u0447\u0438\u0441\u043b\u0435 \u0432 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0438 \u0441 \u0432\u0438\u0440\u0443\u0441\u0430\u043c\u0438 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u0432 B \u0438 C, \u0430\u043d\u0442\u0438\u0432\u0438\u0440\u0443\u0441\u043d\u044b\u043c\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430\u043c\u0438 \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0438 \u041f\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u044f \u043e\u0431 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0438 \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0435\u043d\u0438\u044f \u043b\u0438\u0446, \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437\u043e\u043c \u0441 \u043c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u0443\u0441\u0442\u043e\u0439\u0447\u0438\u0432\u043e\u0441\u0442\u044c\u044e \u0432\u043e\u0437\u0431\u0443\u0434\u0438\u0442\u0435\u043b\u044f, \u0430\u043d\u0442\u0438\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437\u043d\u044b\u043c\u0438 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430\u043c\u0438 \u0434\u043b\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f\u00bb [Postanovlenie Pravitel'stva RF ot 28.12.2016 \u21161512 \u201cOb utverzhdenii Polozheniia ob organizatsii obespecheniia lits, infitsirovannykh virusom immunodefitsita cheloveka, v tom chisle v sochetanii s virusami gepatitov B i C, antivirusnymi lekarstvennymi preparatami dlia meditsinskogo primeneniia i Polozheniia ob organizatsii obespecheniia lits, bol'nykh tuberkulezom s mnozhestvennoi lekarstvennoi ustoichivost'iu vozbuditelia, antibakterial'nymi i protivotuberkuleznymi lekarstvennymi preparatami dlia meditsinskogo primeneniia\u201d (in Russian)]."},{"key":"ref20","unstructured":"\u041f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0435 \u041f\u0440\u0430\u0432\u0438\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0430 \u0420\u0424 \u043e\u0442 30.07.1994 \u2116890 (\u0440\u0435\u0434. \u043e\u0442 14.02.2002) \u00ab\u041e \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u043a\u0435 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u0440\u043e\u043c\u044b\u0448\u043b\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0438 \u0443\u043b\u0443\u0447\u0448\u0435\u043d\u0438\u0438 \u043e\u0431\u0435\u0441\u043f\u0435\u0447\u0435\u043d\u0438\u044f \u043d\u0430\u0441\u0435\u043b\u0435\u043d\u0438\u044f \u0438 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0439 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c\u0438 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430\u043c\u0438 \u0438 \u0438\u0437\u0434\u0435\u043b\u0438\u044f\u043c\u0438 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u044f\u00bb [Postanovlenie Pravitel'stva RF ot 30.07.1994 \u2116890 (red. ot 14.02.2002) \u201cO gosudarstvennoi podderzhke razvitiia meditsinskoi promyshlennosti i uluchshenii obespecheniia naseleniia i uchrezhdenii zdravookhraneniia lekarstvennymi sredstvami i izdeliiami meditsinskogo naznacheniia\u201d (in Russian)]."},{"key":"ref21","unstructured":"\u041a\u043e\u0430\u043b\u0438\u0446\u0438\u044f \u043f\u043e \u0433\u043e\u0442\u043e\u0432\u043d\u043e\u0441\u0442\u0438 \u043a \u043b\u0435\u0447\u0435\u043d\u0438\u044e. \u0410\u043d\u0430\u043b\u0438\u0437 \u0437\u0430\u043a\u0443\u043f\u043e\u043a \u0410\u0420\u0412-\u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0432 \u0420\u043e\u0441\u0441\u0438\u0438\u0306\u0441\u043a\u043e\u0438\u0306 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438 \u0432 2019 \u0433\u043e\u0434\u0443. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/www.itpcru.org\/wp-content\/uploads\/2020\/04\/itpcru-otchet-arv-preparaty-2019-28.04.20-final_prep.pdf. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 12.10.2021 [Koalitsiia po gotovnosti k lecheniiu. Analiz zakupok ARV-preparatov v Rossiiskoi Federatsii v 2020 godu. Available at: https:\/\/www.itpcru.org\/wp-content\/uploads\/2020\/04\/itpcru-otchet-arv-preparaty-2019-28.04.20-final_prep.pdf. Accessed: 12.10.2021 (in Russian)]."},{"key":"ref22","unstructured":"\u041a\u043e\u0430\u043b\u0438\u0446\u0438\u044f \u043f\u043e \u0433\u043e\u0442\u043e\u0432\u043d\u043e\u0441\u0442\u0438 \u043a \u043b\u0435\u0447\u0435\u043d\u0438\u044e. \u0410\u043d\u0430\u043b\u0438\u0437 \u0437\u0430\u043a\u0443\u043f\u043e\u043a \u0410\u0420\u0412-\u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0432 \u0420\u043e\u0441\u0441\u0438\u0438\u0306\u0441\u043a\u043e\u0438\u0306 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438 \u0432 2020 \u0433\u043e\u0434\u0443. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/www.itpcru.org\/wp-content\/uploads\/2021\/05\/arvt-2020-final-28.05.21.pdf. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 12.10.2021 [Koalitsiia po gotovnosti k lecheniiu. Analiz zakupok ARV-preparatov v Rossiiskoi Federatsii v 2020 godu. Available at: https:\/\/www.itpcru.org\/wp-content\/uploads\/2021\/05\/arvt-2020-final-28.05.21.pdf. Accessed: 12.10.2021 (in Russian)]."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.08.863"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.08.904"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/96477\/70731","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/96477\/70731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T16:24:26Z","timestamp":1726503866000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/96477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":24,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.12.201296","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2021,12,15]]}}}