{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:12:11Z","timestamp":1792015931149,"version":"4.4.0"},"reference-count":94,"publisher":"Consilium Medicum","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>The article presents an analysis of the literature on food intolerance (FS) associated with the presence in the diet of fermentable oligodimosaccharides and polyols FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols), histamine and food additives. The relationship between FS and insufficient activity of enzymes of the small intestine mucosa, in particular, in patients with irritable bowel syndrome, is discussed. FS often noted in them forces them to strictly adhere to the elimination diet and significantly impair the quality of life due to dissatisfaction with the results of treatment. Analysis of the literature has confirmed in many patients with irritable bowel syndrome an etiotropic relationship with poor food tolerance and dictates the need for randomized studies to further study the pathogenetic mechanisms of increasing food tolerance under the influence of cytoprotective therapy.<\/jats:p>","DOI":"10.26442\/00403660.2022.02.201364","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:27:58Z","timestamp":1648646878000},"page":"153-159","source":"Crossref","is-referenced-by-count":2,"title":["Food intolerances and the small intestine"],"prefix":"10.26442","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9782-4860","authenticated-orcid":false,"given":"Asfold I.","family":"Parfenov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13041"},{"key":"ref2","unstructured":"\u041d\u043e\u0433\u0430\u043b\u043b\u0435\u0440 \u0410.\u041c. \u041f\u0438\u0449\u0435\u0432\u0430\u044f \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u044f. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 1983 [Nogaller AM. Pishchevaia allergiia. Moscow: Medicina, 1983 (in Russian)]."},{"key":"ref3","unstructured":"\u041b\u0443\u0441\u0441 \u041b.\u0412. \u041f\u0438\u0449\u0435\u0432\u0430\u044f \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u044f \u0438 \u043f\u0438\u0449\u0435\u0432\u0430\u044f \u043d\u0435\u043f\u0435\u0440\u0435\u043d\u043e\u0441\u0438\u043c\u043e\u0441\u0442\u044c, \u0442\u0435\u0440\u043c\u0438\u043d\u043e\u043b\u043e\u0433\u0438\u044f, \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044f, \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u044b \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438 \u0442\u0435\u0440\u0430\u043f\u0438\u0438. \u041c., 2005 [Luss LV. Pishchevaia allergiia i pishchevaia neperenosimost', terminologiia, klassifikatsiia, problemy diagnostiki i terapii. Moscow, 2005 (in Russian)]."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12984"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-017-0011-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071684"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182942"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh201789445-52"},{"key":"ref9","unstructured":"\u041f\u0430\u0440\u0444\u0435\u043d\u043e\u0432 \u0410.\u0418. \u042d\u043d\u0442\u0435\u0440\u043e\u043f\u0430\u0442\u0438\u044f \u0441 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435\u043c \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u043e\u0433\u043e \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f. \u041c.: \u041c\u0435\u0434\u043a\u043e\u043d\u0433\u0440\u0435\u0441\u0441, 2019 [Parfenov AI. Enteropatiia s narusheniem membrannogo pishchevareniia. Moscow: Medkongress, 2019 (in Russian)]."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-015-0028-0"},{"key":"ref11","unstructured":"\u0423\u0433\u043e\u043b\u0435\u0432 \u0410.\u041c. \u042d\u0432\u043e\u043b\u044e\u0446\u0438\u044f \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f \u0438 \u0438 \u043f\u0440\u0438\u043d\u0446\u0438\u043f\u044b \u044d\u0432\u043e\u043b\u044e\u0446\u0438\u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u0439. \u041b.: \u041d\u0430\u0443\u043a\u0430, 1985 [Ugolev AM. Evoliutsiia pishchevareniia i i printsipy evoliutsii funktsii. Leningrad: Science, 1985 (in Russian)]."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Weijers HA, van de Kamer JH, Mossel DA, Dicke WK. Diarrhoea caused by deficiency of sugar-splitting enzymes. Lancet. 1960;2:296-7.","DOI":"10.1016\/S0140-6736(60)91381-7"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Gudmand-Hoyer E, Krasilnikoff PA. The effect of sucrose malabsorption on the growth pattern in children. Scand J Gastroenterol. 1977;12:103-7.","DOI":"10.1080\/00365521.1977.12031119"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030157"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312456"},{"key":"ref16","unstructured":"\u041f\u0430\u0440\u0444\u0435\u043d\u043e\u0432 \u0410.\u0418., \u0411\u0435\u043b\u043e\u0441\u0442\u043e\u0446\u043a\u0438\u0439 \u041d.\u0418., \u0414\u0431\u0430\u0440 \u0421.\u0420., \u0438 \u0434\u0440. \u042d\u043d\u0442\u0435\u0440\u043e\u043f\u0430\u0442\u0438\u044f \u0441 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435\u043c \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u043e\u0433\u043e \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f. \u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0413\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2018;16:20-7 [Parfenov AI, Belostotsky NI, Dbar SR, et al. Enteropathy with disorder of membrane digestion. Effective pharmacotherapy. Gastroenterology. 2018;16:20-7 (in Russian)]."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05780-7"},{"key":"ref18","unstructured":"Cohen SA. Disaccharidase activity in children undergoing esophagogastroduodenoscopy. Presented: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Washington, A536, 2015;25."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14349"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Tsukahara T, Kishino E, Inoue R, et al. Correlation between villous height and the disaccharidase activity in the small intestine of piglets from nursing to growing. Anim Sci J. 2013;84:54-9.","DOI":"10.1111\/j.1740-0929.2012.01039.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-0929.2012.01039"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh201587224-29"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.03.00"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Chumpitazi BP, Robayo-Torres CC, Tsai CM, et al. Yield of prospective disaccharidase testing in children with recurrent abdominal pain. Gastroenterology. 2013;144(5 Suppl 1):S401-2.","DOI":"10.1016\/S0016-5085(13)61477-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-242"},{"key":"ref26","unstructured":"\u041f\u0430\u0440\u0444\u0435\u043d\u043e\u0432 \u0410.\u0418. \u041d\u043e\u0432\u044b\u0435 \u0433\u043e\u0440\u0438\u0437\u043e\u043d\u0442\u044b \u0438\u0437\u0443\u0447\u0435\u043d\u0438\u044f \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u043a \u0433\u043b\u044e\u0442\u0435\u043d\u0443. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2013;85(2):4-7 [Parfenov AI. New horizons of gluten sensitivity studies. Terapevticheskii Arkhiv (Ter. Arkh.). 2013;85(2):4-7 (in Russian)]."},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.01.029"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/654143"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102660"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064966"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Biological Hazards (BIOHAZ). Scientific opinion on risk based control of biogenic amine formation in fermented foods. EFSA J. 2011;9:1-93.","DOI":"10.2903\/j.efsa.2011.2393"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2018.00152"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.06.029"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.814244"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/all.13663"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Comas-Bast\u00e9 O, Latorre-Moratalla ML, S\u00e1nchez-P\u00e9rez S, et al. Histamine and other biogenic amines in food. From scombroid poisoning to histamine intolerance. In: Biogenic Amines; Proestos, C., Ed.; IntechOpen. London, 2019.","DOI":"10.5772\/intechopen.84333"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00500"},{"key":"ref38","unstructured":"FAO (Food and Agriculture Organization of the United Nations); WHO (World Health Organization). Histamine in Salmonids. Joint FAO\/WHO Literature Review; World Health Organization: Geneva, Switzerland, 2018."},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.11.011"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-017-0571-3"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4893501"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1791049"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109738"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21588"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2016.00824"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3390\/foods7120205"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2016.04.015"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Parker AM, Watson RR. Lactose intolerance in nutrients in dairy and their implications for health and disease. Amsterdam: Elsevier, 2017; p. 205-11.","DOI":"10.1016\/B978-0-12-809762-5.00016-4"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15069"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.109201"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015617170"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-019-00627-3"},{"key":"ref53","unstructured":"Young E, Patel S, Stoneham M, et al. The prevalence of reaction to food additives in a survey population. J R Coll Phys Lond. 1987;21:241-24769."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11436241"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.159681"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00096"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101789"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052132"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.021"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1017\/S095442241700004X"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515003864"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1038\/nature14232"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00057"},{"key":"ref64","unstructured":"Swain A, Soutter V, Loblay R. Elimination Diet. Handbook; allergy unit Royal Prince Alfred Hospital; Allergy Unit, Royal Prince Alfred Hospital. Sydney, 2009."},{"key":"ref65","unstructured":"Holton KF, Taren DL, Thomson CA, et al. The effect of dietary glutamate on fibromyalgia and irritable bowel symptoms. Clin Exp Rheumatol. 2012;30:10-7."},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313099"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i27.6296"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Dahlqvist A. Specificity of the human intestinal disaccharidases and implications for hereditary disaccharide intolerance. J Clin Invest. 1962;41:3-8.","DOI":"10.1172\/JCI104499"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Trinder P. Depermination of glucosa in blood using glucosa oxidase with an alternative oxigen reception. J Ann Clin Biochem. 1969;6:24-7.","DOI":"10.1177\/000456326900600108"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308388"},{"key":"ref71","unstructured":"Rana SV, Bhasin DK, Katyal R, Singh K. Comparison of duodenal and jejunal disaccharidase levels in patients with non ulcer dyspepsia. Trop Gastroenterol. 2001;22:135-6."},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616657978"},{"key":"ref73","unstructured":"\u042d\u043d\u0442\u0435\u0440\u043e\u043f\u0430\u0442\u0438\u044f \u0441 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435\u043c \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u043e\u0433\u043e \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f. \u041c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u0420\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u043e\u0432\u0430\u043d\u044b \u044d\u043a\u0441\u043f\u0435\u0440\u0442\u043d\u044b\u043c \u0441\u043e\u0432\u0435\u0442\u043e\u043c \u043f\u043e \u043d\u0430\u0443\u043a\u0435 \u0414\u0417\u041c \u0433. \u041c\u043e\u0441\u043a\u0432\u044b 18.05.21 [Enteropatiia s narusheniem membrannogo pishchevareniia. Metodicheskie rekomendatsii. Rekomendovany ekspertnym sovetom po nauke DZM g. Moskvy 18.05.21 (in Russian)]."},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.77"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313128"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.055"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311339"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.046"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.07.00"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.010"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000421"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13167"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.386"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.062"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12530"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705213162104"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2021.02.200602"},{"key":"ref89","unstructured":"Arakawa T, Kobayashi K, Yoshikawa T, et al. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci. 1998;43:5S-13S."},{"key":"ref90","unstructured":"Tarnawski A, Arakawa T, Kobayashi K. Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: one mechanism for its ulcer healing action? Dig Dis Sci. 1998;43:90S-8S."},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1023\/b:ddas.0000017439.60943.5c"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"\u041c\u0430\u0435\u0432 \u0418.\u0412., \u041a\u0430\u0437\u044e\u043b\u0438\u043d \u0410.\u041d. \u041d\u043e\u0432\u044b\u0435 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438 \u0440\u0430\u043a\u0430 \u0436\u0435\u043b\u0443\u0434\u043a\u0430. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2017;89(4):101-9 [Maev IV, Kazyulin AN. New possibilities for the prevention of stomach cancer. Terapevticheskii Arkhiv (Ter. Arkh.). 2017;89(4):101-9 (in Russian)]. DOI:10.171 16\/terarkh2017894101-109","DOI":"10.17116\/terarkh2017894101-109"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02154.x"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000126436.25751.f"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/105506\/79926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/105506\/79926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:29:14Z","timestamp":1648646954000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/105506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":94,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2022.02.201364","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,15]]}}}