{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:33:59Z","timestamp":1740180839971,"version":"3.37.3"},"reference-count":23,"publisher":"Consilium Medicum","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To characterize of the features of changes in the cavity and parietal microbiota of the small intestine in patients with non-alcoholic fatty liver disease (NAFLD).\r\nMaterials and methods. Fifty four patients with NAFLD at the stage of steatosis and steatohepatitis at the age of 1860 years were examined. The diagnosis was verified by ultrasound of the hepatobiliary system using a SONIX OP analyzer (Canada), FibroMax test data and liver elastography using an AIXPLORER apparatus (France). The degree of steatohepatitis activity was determined by biochemical blood tests for alanine aminotransferase and aspartate aminotransferase on a Huma Star 600 analyzer (Germany). The cavity microbiota of the small intestine was evaluated using a Lactofan2 analyzer of the Association of Medicine and Analytics company (Russia) using hydrogen breath tests with lactulose. The parietal microbiota of the small intestine was examined using an Agilent 7890 gas chromatograph with mass-selective and plasma-ionization detectors (Agilent Technologies, USA).\r\nResults. In the study of cavity enteric microbiota in patients with NAFLD, the syndrome of excessive bacterial growth was detected in 68.5% of cases, while it was caused in 48.6% of patients by a violation of the function of the ileocecal valve, in 21.7%  by a deficiency of cleavage of lactulose microorganisms and\/or slowing down the motility of the digestive tract. When studying the parietal enteral microbiota, the total bacterial load in patients with NAFLD was significantly lower compared with the control group due to a decrease in useful microbiota. At the same time, a decrease in all normal bacterial representatives  Bifidobacterium, Lactobacillus and Lactococcus, Eubacterium and Propionibacterium  was noted. The content of opportunistic microbiota in patients with NAFLD did not reveal significant changes.\r\nConclusion. The syndrome of excessive bacterial growth in patients with NAFLD is associated with a decrease in useful parietal enteral microbiota.<\/jats:p>","DOI":"10.26442\/00403660.2022.02.201369","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:27:58Z","timestamp":1648646878000},"page":"188-193","source":"Crossref","is-referenced-by-count":0,"title":["The study of abdominal and parietal enteric microbiota in patients with non-alcoholic fatty liver disease"],"prefix":"10.26442","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-2658","authenticated-orcid":false,"given":"Yakov M.","family":"Vakhrushev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-6316","authenticated-orcid":false,"given":"Anna P.","family":"Lukashevich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-2746","authenticated-orcid":false,"given":"Mariia V.","family":"Lyapina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"ref1","unstructured":"\u041f\u043e\u043b\u0443\u043d\u0438\u043d\u0430 \u0422.\u0415., \u041c\u0430\u0435\u0432 \u0418.\u0412. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438: \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u044f, \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u043b\u0435\u0447\u0435\u043d\u0438\u0435. Consilium Medicum. \u0413\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2012;14(1):35-40 [Polunina TE, Mayev IV. Non-alcoholic fatty liver disease: epidemiology, pathogenesis, diagnosis, treatment. Consilium Medicum. Gastroenterology. 2012;14(1):35-40 (in Russian)]."},{"key":"ref2","unstructured":"\u0410\u0440\u0434\u0430\u0442\u0441\u043a\u0430\u044f \u041c.\u0414., \u0413\u0430\u0440\u0443\u0448\u044c\u044f\u043d \u0413.\u0412., \u041c\u043e\u0439\u0441\u0430\u043a \u0420.\u041f., \u0422\u043e\u043f\u0447\u0438\u0439 \u0422.\u0411. \u0421\u0438\u043d\u0434\u0440\u043e\u043c \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0432 \u0442\u043e\u043d\u043a\u043e\u0439 \u043a\u0438\u0448\u043a\u0435 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u043f\u0435\u0447\u0435\u043d\u0438. \u041a\u0440\u0435\u043c\u043b\u0435\u0432\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0435\u0441\u0442\u043d\u0438\u043a. 2018;4:92-7 [Ardatskaya MD, Garushyan GV, Moysak RP, Topchiy TB. Prevalence of small intestinal bacterial overgrowth syndrome in patients with nonalcoholic fatty liver disease. Kremlin Medicine Journal. 2018;4:92-7 (in Russian)]."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"ref4","unstructured":"\u0411\u0430\u0431\u0435\u043d\u043a\u043e \u0410.\u042e., \u041b\u0430\u0435\u0432\u0441\u043a\u0430\u044f \u041c.\u042e. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438 \u2013 \u0432\u0437\u0430\u0438\u043c\u043e\u0441\u0432\u044f\u0437\u0438 \u0441 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u043e\u043c. \u0420\u0443\u0441. \u043c\u0435\u0434. \u0436\u0443\u0440\u043d. 2018;1(I):34-40 [Babenko AYu, Laevskaya MYu. Non-alcoholic fatty liver disease \u2013 relationships with metabolic syndrome. Russian Medical Journal. 2018;1(I):34-40 (in Russian)]."},{"key":"ref5","unstructured":"\u0424\u0438\u043b\u0430\u0442\u043e\u0432\u0430 \u0418.\u0410., \u041a\u043e\u0437\u043b\u043e\u0432\u0430 \u041d.\u041c., \u0422\u0438\u0440\u0438\u043a\u043e\u0432\u0430 \u041e.\u0412., \u0438 \u0434\u0440. \u0420\u043e\u043b\u044c \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0432 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0435 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438. \u0414\u043d\u0435\u0432\u043d\u0438\u043a \u041a\u0430\u0437\u0430\u043d\u0441\u043a\u043e\u0439 \u043c\u0435\u0434. \u0448\u043a\u043e\u043b\u044b. 2018;4(22):104-8 [Filatova IA, Kozlova NM, Tiricova OV, et al. The role of small intestinal bacterial overgrowth syndrome in the pathogenesis of non-alcoholic fatty liver disease. Kazan Medical School Diary. 2018;4(22):104-8 (in Russian)]."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.25298\/2616-5546-2019-3-1-5-13"},{"key":"ref7","unstructured":"\u041c\u0430\u0435\u0432\u0441\u043a\u0430\u044f \u0415.\u0410., \u041a\u0443\u0447\u0435\u0440\u044f\u0432\u044b\u0439 \u042e.\u0410., \u041c\u0430\u0435\u0432 \u0418.\u0412. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0437\u0430\u043f\u043e\u0440: \u0441\u043b\u0443\u0447\u0430\u0439\u043d\u043e\u0441\u0442\u044c \u0438\u043b\u0438 \u043e\u0447\u0435\u0432\u0438\u0434\u043d\u0430\u044f \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u044f \u0432 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0430. \u041a\u043b\u0438\u043d. \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u044b \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2015;1:27-36 [Mayevskaya YeA, Kucheryavy YuA, Mayev IV. Non-alcoholic fatty liver disease and chronic constipation: casual or obvious association in practice of the gasrtoenterologist. Klinicheskie perspektivy gastroenterologii, gepatologii. 2015;1:27-36 (in Russian)]."},{"key":"ref8","unstructured":"\u041f\u043e\u043b\u0443\u044d\u043a\u0442\u043e\u0432\u0430 \u0415.\u0410., \u041b\u044f\u0448\u0435\u043d\u043a\u043e \u041e.\u0421., \u0428\u0438\u0444\u0440\u0438\u043d \u041e.\u0421., \u0438 \u0434\u0440. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0438\u0437\u0443\u0447\u0435\u043d\u0438\u044f \u043c\u0438\u043a\u0440\u043e\u0444\u043b\u043e\u0440\u044b \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430. \u0420\u043e\u0441. \u0436\u0443\u0440\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438, \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2014;2:85-91 [Poluektova EA, Lyashenko OS, Shifrin OS, et al. Modern methods of studying of human gastro-intestinal microflora. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014;2:85-91 (in Russian)]."},{"key":"ref9","unstructured":"\u041e\u0441\u0438\u043f\u043e\u0432 \u0413.\u0410., \u041f\u0430\u0440\u0444\u0435\u043d\u043e\u0432 \u0410.\u0418., \u0420\u0443\u0447\u043a\u0438\u043d\u0430 \u0418.\u041d., \u0438 \u0434\u0440. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043c\u0438\u043a\u0440\u043e\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u043e\u0432 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439 \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0438 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430 \u043a\u0443\u043b\u044c\u0442\u0443\u0440\u0430\u043b\u044c\u043d\u043e-\u0431\u0438\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0438 \u0445\u0440\u043e\u043c\u0430\u0442\u043e-\u043c\u0430\u0441\u0441-\u0441\u043f\u0435\u043a\u0442\u0440\u043e\u043c\u0435\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043c\u0435\u0442\u043e\u0434\u0430\u043c\u0438. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c. \u0438 \u043a\u043b\u0438\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2003;4:59-67 [Osipov GA, Parfenov AI, Ruchkina IN, et al. The clinical significance of the study of microorganisms of the intestinal mucosa by cultural-biochemical and chromato-mass spectrometric methods. Experimental and Clinical Gastroenterology. 2003;4:59-67 (in Russian)]."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.37482\/2542-1298-Z009"},{"key":"ref11","unstructured":"\u0421\u0430\u0431\u0435\u043b\u044c\u043d\u0438\u043a\u043e\u0432\u0430 \u0415.\u0410. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u0441\u043f\u0435\u043a\u0442\u044b \u0434\u0438\u0441\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u043e\u0437\u0430 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c. \u0438 \u043a\u043b\u0438\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2011;3:111-6 [Sabelnikova EA. Clinical aspects of intestinal dysbiosis. Experimental and \u0421linical Gastroenterology. 2011;3:111-6 (in Russian)]."},{"key":"ref12","unstructured":"\u041c\u0430\u0440\u0442\u044b\u043d\u043e\u0432 \u0412.\u041b., \u0425\u0430\u0439\u0440\u0434\u0438\u043d\u043e\u0432 \u0410.\u0425., \u041a\u0430\u0437\u0430\u0440\u0438\u043d\u0430 \u041d.\u0412. \u041d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c \u0431\u0430\u0443\u0433\u0438\u043d\u0438\u0435\u0432\u043e\u0439 \u0437\u0430\u0441\u043b\u043e\u043d\u043a\u0438 \u043a\u0430\u043a \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0442\u043e\u043d\u043a\u043e\u0439 \u043a\u0438\u0448\u043a\u0438. \u041c\u0435\u0434. \u0430\u043b\u044c\u043c\u0430\u043d\u0430\u0445. 2015;1(36):46-50 [Martynov VL, Khayrdinov AKh, Kazarina NV. Insufficiency of the bauginium damper as a cause of the syndrome of excessive bacterial growth of the small intestine. Medical Almanac. 2015;1(36):46-50 (in Russian)]."},{"key":"ref13","unstructured":"\u0428\u0435\u043f\u0435\u043b\u0435\u0432 \u0410.\u041d., \u0414\u0440\u043e\u043d\u043e\u0432\u0430 \u041e.\u0411., \u041a\u0430\u0433\u0430\u043d \u0418.\u0418., \u0424\u0430\u0442\u0435\u0435\u0432 \u0418.\u041d. \u0421\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0430\u043d\u0430\u0442\u043e\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0441\u0442\u0440\u043e\u0435\u043d\u0438\u044f \u0438\u043b\u0435\u043e\u0446\u0435\u043a\u0430\u043b\u044c\u043d\u043e\u0439 \u043e\u0431\u043b\u0430\u0441\u0442\u0438. \u0424\u0443\u043d\u0434\u0430\u043c. \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f. 2015;1(4):859-62 [Shepelev AN, Dronova OB, Kagan II, Fateev IN. The study of the anatomical structure ileocecal region. Fundamental Research. 2015;1(4):859-62 (in Russian)]."},{"key":"ref14","unstructured":"\u0424\u0435\u0434\u043e\u0441\u044c\u0438\u043d\u0430 \u0415.\u0410., \u0416\u0430\u0440\u043a\u043e\u0432\u0430 \u041c.\u0421., \u041c\u0430\u0435\u0432\u0441\u043a\u0430\u044f \u041c.\u0412. \u0411\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u043a\u0438\u0448\u0435\u0447\u043d\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0444\u043b\u043e\u0440\u0430 \u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438. \u0420\u043e\u0441. \u0436\u0443\u0440\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2009;19(6):73-81 [Fedosyina YeA, Zharkova MS, Maevskaya MV. Bacterial intestinal microflora and diseases of the liver. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(6):73-81 (in Russian)]."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.20514\/2226-6704-2019-9-1-64-69"},{"key":"ref16","unstructured":"\u041d\u0435\u043c\u0446\u043e\u0432 \u041b.\u041c. \u0421\u0438\u043d\u0434\u0440\u043e\u043c \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0432 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0435 \u043f\u0440\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u043f\u0435\u0447\u0435\u043d\u0438. \u0417\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435. 2015;4:26-34 [Nemtsov LM. Syndrome of bacteria overgrowth under liver diseases. Zdravookhranenie. 2015;4:26-34 (in Russian)]."},{"key":"ref17","unstructured":"\u0414\u0436\u0443\u043b\u0430\u0439 \u0413.\u0421., \u0429\u0435\u043b\u043e\u0447\u0435\u043d\u043a\u043e\u0432 \u0421.\u0412. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u0442\u0430 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430 \u0432 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0438 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438 (\u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b). \u0412\u0435\u0440\u0445\u043d\u0435\u0432\u043e\u043b\u0436\u0441\u043a\u0438\u0439 \u043c\u0435\u0434. \u0436\u0443\u0440\u043d. 2015;14(3):36-41 [Dzhulay GS, Schelochenkov SV. Gastrointestinal microbiota in development of non-alcoholic fatty liver disease (literature review). Verhnevolzhskii medicinskii zhurnal. 2015;14(3):36-41 (in Russian)]."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.17816\/brmma25948"},{"key":"ref19","unstructured":"\u0422\u043a\u0430\u0447\u0435\u043d\u043a\u043e \u0415.\u0418., \u0423\u0441\u043f\u0435\u043d\u0441\u043a\u0438\u0439 \u042e.\u041f., \u0411\u0435\u043b\u043e\u0443\u0441\u043e\u0432\u0430 \u041b.\u041d., \u041f\u0435\u0442\u0440\u0435\u043d\u043a\u043e \u0412.\u0412. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c: \u0435\u0434\u0438\u043d\u0441\u0442\u0432\u043e \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u043e\u0432 \u0438 \u043f\u043e\u0434\u0445\u043e\u0434\u043e\u0432 \u043a \u043b\u0435\u0447\u0435\u043d\u0438\u044e. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c. \u0438 \u043a\u043b\u0438\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2008;2:93-7 [Tkachenko EI, Uspensky YuP, Belousova LN, Petrenko VV. Non-alcoholic fatty liver disease and metabolic syndrome: the unity of pathogenetic mechanisms and approaches to treatment. Experimental and Clinical Gastroenterology. 2008;2:93-7 (in Russian)]."},{"key":"ref20","unstructured":"\u0411\u043e\u043d\u0434\u0430\u0440\u0435\u043d\u043a\u043e \u0412.\u041c., \u0420\u044b\u0431\u0430\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u041e.\u0412., \u0415\u0440\u043e\u0444\u0435\u0435\u0432 \u041d.\u041f. \u0420\u043e\u043b\u044c \u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0439 \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u0442\u044b \u0432 \u043e\u0431\u043c\u0435\u043d\u0435 \u0445\u043e\u043b\u0435\u0441\u0442\u0435\u0440\u0438\u043d\u0430 \u0438 \u0440\u0435\u0446\u0438\u0440\u043a\u0443\u043b\u044f\u0446\u0438\u0438 \u0436\u0435\u043b\u0447\u043d\u044b\u0445 \u043a\u0438\u0441\u043b\u043e\u0442. \u041b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430. 2013;3(7):65-73 [Bondarenko VM, Rybalchenko OV, Yerofeyev NP. The role of intestinal microbiota in metabolism of cholesterol and recirculation of bile acids. Disease Treatment and Prevention. 2013;3(7):65-73 (in Russian)]."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2019.11.000300"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2019.02.000051"},{"key":"ref23","unstructured":"\u0410\u0440\u0434\u0430\u0442\u0441\u043a\u0430\u044f \u041c.\u0414. \u0421\u0438\u043d\u0434\u0440\u043e\u043c \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u043e\u0432 \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f \u0438 \u0432\u0441\u0430\u0441\u044b\u0432\u0430\u043d\u0438\u044f. \u041f\u043e\u043b\u0438\u043a\u043b\u0438\u043d\u0438\u043a\u0430. 2009;2:38-40 [Ardatskaya MD. Syndrome of excessive bacterial growth and impaired digestion and absorption. Policlinika. 2009;2:38-40 (in Russian)]."}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/105536\/79940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/105536\/79940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:29:10Z","timestamp":1648646950000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/105536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2022.02.201369","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2022,2,15]]}}}