{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:40:25Z","timestamp":1794199225265,"version":"4.8.0"},"reference-count":57,"publisher":"Consilium Medicum","issue":"3","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Works of V.P. Filatov and his school laid the foundation for the study and clinical use of human placenta hydrolysates (HPH). To date, the PubMed database contains more than 5,000 publications on basic and clinical research on HPH. Studies of the peptide composition of HPH, carried out using the methods of modern proteomics, have made it possible to propose a complex of molecular mechanisms of the action of HPH in various pathologies. The article discusses the effects of HPH on the treatment of liver diseases, atopic dermatitis, viral infections (herpes, COVID-19, viral hepatitis), iron overload and chronic fatigue syndrome. Stimulation of HPH regenerative capabilities of the body is important for accelerating and improving the quality of wound healing, treatment of diseases of the joints and the reproductive system.<\/jats:p>","DOI":"10.26442\/00403660.2022.03.201408","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T13:05:02Z","timestamp":1650373502000},"page":"434-441","source":"Crossref","is-referenced-by-count":11,"title":["Human placenta hydrolysates: from V.P. Filatov to the present day: Review"],"prefix":"10.26442","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-710X","authenticated-orcid":false,"given":"Olga A.","family":"Gromova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2659-7998","authenticated-orcid":false,"given":"Ivan Yu.","family":"Torshin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-5450","authenticated-orcid":false,"given":"Alexander G.","family":"Chuchalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-1071","authenticated-orcid":false,"given":"Valeriy \u0410.","family":"Maximov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref1","unstructured":"\u0424\u0438\u043b\u0430\u0442\u043e\u0432 \u0412.\u041f. \u0422\u043a\u0430\u043d\u0435\u0432\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u041c., 1950, \u0422. XXVIII, \u21161, c. 22-8 [Filatov VP. Tkanevaya terapiya. Klinicheskaia meditsina. Moscow, 1950, T. XXVIII, No.1, p. 22-8 (in Russian)]."},{"key":"ref2","unstructured":"\u041c\u0430\u043a\u0441\u0438\u043c\u043e\u0432 \u0412.\u0410., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0414\u0438\u0431\u0440\u043e\u0432\u0430 \u0415.\u0410. \u0421\u0431\u043e\u0440\u043d\u0438\u043a \u0430\u0432\u0442\u043e\u0440\u0435\u0444\u0435\u0440\u0430\u0442\u043e\u0432 \u0434\u043e\u043a\u0442\u043e\u0440\u0441\u043a\u0438\u0445 \u0438 \u043a\u0430\u043d\u0434\u0438\u0434\u0430\u0442\u0441\u043a\u0438\u0445 \u0434\u0438\u0441\u0441\u0435\u0440\u0442\u0430\u0446\u0438\u0439 \u043f\u043e \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0435 \u0442\u043a\u0430\u043d\u0435\u0432\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430. \u041c.: \u041f\u0435\u0447\u0430\u0442\u043d\u043e\u0435 \u0431\u044e\u0440\u043e \u00ab\u041c\u043e\u0434\u0443\u043b\u044c\u00bb, 2022 [Maksimov VA, Gromova OA, Dibrova EA. Sbornik avtoreferatov doktorskikh i kandidatskikh dissertatsii po probleme tkanevoi terapii platsenty cheloveka. Moscow: Pechatnoe biuro \"Modul'\", 2022 (in Russian)]."},{"key":"ref3","unstructured":"\u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0417\u0433\u043e\u0434\u0430 \u0412.\u0413., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0438 \u0434\u0440. \u0410\u043d\u0430\u043b\u0438\u0437 \u043b\u0435\u0433\u043a\u043e\u0439 \u043f\u0435\u043f\u0442\u0438\u0434\u043d\u043e\u0439 \u0444\u0440\u0430\u043a\u0446\u0438\u0438 \u041b\u0430\u0435\u043d\u043d\u0435\u043a\u0430 \u043c\u0435\u0442\u043e\u0434\u0430\u043c\u0438 \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u043f\u0440\u043e\u0442\u0435\u043e\u043c\u0438\u043a\u0438. \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u043a\u0438\u043d\u0435\u0442\u0438\u043a\u0430 \u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0430. 2016;(4):31-42 [Torshin IYu, Zgoda VG, Gromova OA, et al. Analysis of the light peptide fraction of Laennec by proteomic methods. Pharmacokinetics and Pharmacodynamics. 2016;(4):31-42 (in Russian)]."},{"key":"ref4","unstructured":"\u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0412\u043e\u043b\u043a\u043e\u0432 \u0410.\u042e., \u0438 \u0434\u0440. \u041f\u0440\u0435\u043f\u0430\u0440\u0430\u0442 \u041b\u0430\u0435\u043d\u043d\u0435\u043a: \u044d\u043b\u0435\u043c\u0435\u043d\u0442\u043d\u044b\u0439 \u0441\u043e\u0441\u0442\u0430\u0432 \u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435. \u041f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u044f \u0438 \u043a\u043e\u0441\u043c\u0435\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2011;2:327-33 [Gromova OA, Torshin IYu, Volkov AYu, et al. Preparation Laennec: elemental composition and key role in the pharmacological action. Plastic Surgery and Cosmetology. 2011;2:327-33 (in Russian)]."},{"key":"ref5","unstructured":"\u0413\u0438\u043b\u0435\u043b\u044c\u0441 \u0410.\u0412., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0438 \u0434\u0440. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0439 \u0430\u043d\u0430\u043b\u0438\u0437 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u043d\u043e\u0433\u043e \u0441\u043e\u0441\u0442\u0430\u0432\u0430 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u00ab\u041b\u0430\u0435\u043d\u043d\u0435\u043a\u00bb. \u0412\u0435\u0441\u0442\u043d\u0438\u043a \u044d\u0441\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u044b. 2013;12(3):80-7 [Gilels AV, Gromova OA, Torshin IYu, et al. Experimental analysis of the vitamin composition of the Laennec preparation. Bulletin of Aesthetic Medicine. 2013;12(3):80-7 (in Russian)]."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.31146\/1682-8658-ecg-170-10-79-89"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.17749\/2070-4909\/farmakoekonomika.2020.021"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"\u041c\u0438\u043d\u0443\u0448\u043a\u0438\u043d \u041e.\u041d., \u041c\u0430\u0441\u043b\u043e\u0432\u0441\u043a\u0438\u0439 \u041b.\u0412., \u0415\u043b\u0438\u0437\u0430\u0432\u0435\u0442\u0438\u043d\u0430 \u0413.\u0410., \u0438 \u0434\u0440. \u041f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u041b\u0430\u0435\u043d\u043d\u0435\u043a \u0432 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435. \u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0413\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2014;50:18-23 [Minushkin ON, Maslovsky LV, Yelizavetina GA, et al. Administration of Laennec in Gatroenterology. Effektivnaya farmakoterapiya. Gastroenterologiya. 2014;50:18-23 (in Russian)].","DOI":"10.3901\/JME.2014.18.023"},{"key":"ref9","unstructured":"\u041f\u0430\u043b\u044c\u0446\u0435\u0432 \u0410.\u0418., \u0415\u0440\u0435\u043c\u0438\u043d\u0430 \u0410.\u0410., \u0422\u043e\u0440\u0433\u0430\u0448\u043e\u0432 \u041c.\u041d. \u0413\u0435\u043f\u0430\u0442\u043e\u0437\u0430\u0449\u0438\u0442\u043d\u0430\u044f \u0440\u043e\u043b\u044c \u0433\u0438\u0434\u0440\u043e\u043b\u0438\u0437\u0430\u0442\u0430 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b \u2013 \u041b\u0430\u0435\u043d\u043d\u0435\u043a\u0430 \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0432\u0438\u0440\u0443\u0441\u043d\u043e-\u043f\u0430\u0440\u0430\u0437\u0438\u0442\u0430\u0440\u043d\u044b\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438 \u043f\u0435\u0447\u0435\u043d\u0438. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2016;11(135):94-9 [Paltsev AI, Eremina AA, Torgashov MN. Hepatoprotective role of placenta hydrolyzate \u2013 Laennec in the treatment of patients with viral and parasitic liver diseases. Experimental and Clinical Gastroenterology. 2016;11(135):94-9 (in Russian)]."},{"key":"ref10","unstructured":"\u041c\u0430\u043a\u0441\u0438\u043c\u043e\u0432 \u0412.\u0410., \u0411\u0443\u043d\u0442\u0438\u043d \u0421.\u0415., \u0411\u0443\u043d\u0442\u0438\u043d\u0430 \u0412.\u0413., \u0438 \u0434\u0440. \u041e \u0432\u043b\u0438\u044f\u043d\u0438\u0438 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u0430\u0440\u043d\u043e\u0433\u043e \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u041b\u0430\u0435\u043d\u043d\u0435\u043a \u043d\u0430 \u043c\u043e\u0442\u043e\u0440\u043d\u0443\u044e \u0444\u0443\u043d\u043a\u0446\u0438\u044e \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0434\u0438\u0441\u0442\u0440\u043e\u0444\u0438\u0435\u0439 \u043f\u0435\u0447\u0435\u043d\u0438. \u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0413\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2015;37:12-5 [Maksimov VA, Buntin SE, Buntina VG, et al. Regarding an Influence of Placental Drug Laennec on Motor Function of Biliary Tract in Patients with Fatty Liver Dystrophy. Effektivnaya farmakoterapiya. Gastroenterologiya. 2015;37:12-5 (in Russian)]."},{"key":"ref11","unstructured":"\u041b\u0430\u0437\u0435\u0431\u043d\u0438\u043a \u041b.\u0411., \u0420\u0430\u0434\u0447\u0435\u043d\u043a\u043e \u0412.\u0413., \u0421\u0435\u043b\u0438\u0432\u0435\u0440\u0441\u0442\u043e\u0432 \u041f.\u0412., \u0438 \u0434\u0440. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u0438\u0435 \u043e \u0444\u0438\u0431\u0440\u043e\u0437\u0435 \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043f\u043e\u0434\u0445\u043e\u0434\u0430\u0445 \u043a \u0435\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u044b\u043c \u0441\u0442\u0435\u0430\u0442\u043e\u0433\u0435\u043f\u0430\u0442\u0438\u0442\u043e\u043c. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2017;148(12):98-109 [Lazebnik LB, Radchenko VG, Seliverstov PV, et al. The contemporary understanding of liver fibrosis and approaches to treatment in patients with nonalcoholic steatohepatitis. Experimental and Clinical Gastroenterology. 2017;148(12):98-109 (in Russian)]."},{"key":"ref12","unstructured":"\u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0417\u0433\u043e\u0434\u0430 \u0412.\u0413., \u0422\u043e\u043c\u0438\u043b\u043e\u0432\u0430 \u0418.\u041a. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044b \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u041b\u0430\u0435\u043d\u043d\u0435\u043a \u043f\u0440\u043e\u0442\u0438\u0432 \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0438 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u044f. \u0422\u0435\u0440\u0430\u043f\u0438\u044f. 2017;5:73-83 [Gromova OA, Torshin IYu, Zgoda VG, Tomilova IK. Molecular mechanisms of action of Laennec Against Development Of Metabolic Syndrome And Obesity. Therapy. 2017;5:73-83 (in Russian)]."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-021-04349-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3830"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.41.1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2017.e00416"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12432"},{"key":"ref18","unstructured":"Samiei F, Jamshidzadeh A, Noorafshan A, Ghaderi A. Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats. Iran J Pharm Res. 2016;15(Suppl.):75-82."},{"key":"ref19","unstructured":"\u0416\u0438\u0434\u043e\u043c\u043e\u0440\u043e\u0432 \u041d.\u042e., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0438 \u0434\u0440. \u041b\u0430\u0435\u043d\u043d\u0435\u043a \u043a\u0430\u043a \u043a\u0430\u0440\u0434\u0438\u043e\u043f\u0440\u043e\u0442\u0435\u043a\u0442\u043e\u0440. \u042d\u0441\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 2013;4:531-8 [Zhidomorov NYu, Gromova OA, Torshin IYu, et al. Laennek kak kardioprotektor. Esteticheskaya meditsina. 2013;4:531-8 (in Russian)]."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02655"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27034"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13317-020-00137-x"},{"key":"ref23","unstructured":"\u041d\u0430\u0437\u0430\u0440\u0435\u043d\u043a\u043e \u041e.\u0410., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0413\u0440\u0438\u0448\u0438\u043d\u0430 \u0422.\u0420., \u0438 \u0434\u0440. \u041a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u044f \u041b\u0430\u0435\u043d\u043d\u0435\u043a\u043e\u043c \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0435\u0440\u0435\u0433\u0440\u0443\u0437\u043a\u0438 \u0436\u0435\u043b\u0435\u0437\u043e\u043c \u043f\u0435\u0447\u0435\u043d\u0438, \u043f\u043e\u0447\u0435\u043a \u0438 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430. \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u043a\u0438\u043d\u0435\u0442\u0438\u043a\u0430 \u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0430. 2017;2:39-44 [Nazarenko OA, Gromova OA, Grishina TR, et al. Correction by Laennec of chronic iron overload liver, kidneys and brain. Farmakokinetika i farmakodinamika. 2017;2:39-44 (in Russian)]."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.17749\/2070-4909\/farmakoekonomika.2020.070"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01637"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03243-z"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051672"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12434"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2017.1417518"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/srep14776"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.986660"},{"key":"ref32","unstructured":"\u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0414\u0438\u0431\u0440\u043e\u0432\u0430 \u0415.\u0410., \u0438 \u0434\u0440. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044b \u0432\u043e\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u044d\u043a\u0441\u0442\u0440\u0430\u043a\u0442\u043e\u0432 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u043d\u0430 \u043f\u0438\u0433\u043c\u0435\u043d\u0442\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u043a\u043e\u0436\u0438. \u0412\u0435\u0441\u0442\u043d\u0438\u043a \u044d\u0441\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u044b. 2012;11(3):70-7 [Gromova OA, Torshin IYu, Dibrova EA, et al. Molekuliarnye mekhanizmy vozdeistviia ekstraktov platsenty cheloveka na pigmentoobrazovanie kozhi. Vestnik esteticheskoi meditsiny. 2012;11(3):70-7 (in Russian)]."},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2316"},{"key":"ref34","unstructured":"\u041b\u0443\u0447\u0438\u043d\u0430 \u0415.\u041d. \u0412\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u041b\u0430\u0435\u043d\u043d\u0435\u043a \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0440\u0443\u0431\u0446\u043e\u0432\u044b\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 \u043a\u043e\u0436\u0438. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0434\u0435\u0440\u043c\u0430\u0442\u043e\u043a\u043e\u0441\u043c\u0435\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2012;4:36-40 [Luchina EN. Possibilities of using Laennec to treat skin scarring changes. Experimental and Clinical Gastroenterology. 2012;4:36-40 (in Russian)]."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1623"},{"key":"ref36","unstructured":"\u041f\u0430\u0442\u0435\u043d\u0442 \u0420\u0424 2606040 \u043e\u0442 01.04.2015. \u0423\u0441\u043c\u0430\u043d\u043e\u0432\u0430 \u0418.\u041d., \u0413\u0435\u0440\u0430\u0441\u0438\u043c\u043e\u0432\u0430 \u041b.\u041f., \u041a\u0430\u0431\u0438\u0440\u043e\u0432\u0430 \u041c.\u0424. \u0438 \u0434\u0440. \u0421\u043f\u043e\u0441\u043e\u0431 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f \u0442\u043a\u0430\u043d\u0435\u0439 \u043f\u0430\u0440\u043e\u0434\u043e\u043d\u0442\u0430 \u0438 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439 \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0438 \u0441 \u044d\u043b\u0435\u043c\u0435\u043d\u0442\u0430\u043c\u0438 \u0433\u0438\u043f\u0435\u0440\u043a\u0435\u0440\u0430\u0442\u043e\u0437\u0430 \u0443 \u043b\u0438\u0446 \u043c\u043e\u043b\u043e\u0434\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/patenton.ru\/patent\/RU2606040C2.pdf. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 03.02.2022 [Patent RUS 2606040\/01.04.2015. Usmanova IN, Gerasimova LP, Kabirova MF, et al. Sposob lecheniya khronicheskogo vospaleniya tkanei parodonta i slizistoi obolochki s elementami giperkeratoza u lits molodogo vozrasta. Available at: https:\/\/patenton.ru\/patent\/RU2606040C2.pdf. Accessed: 03.02.2022 (in Russian)]."},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro201711711?-?"},{"key":"ref38","unstructured":"\u0414\u0443\u0434\u043d\u0438\u043a \u0415.\u041d., \u041a\u0430\u043b\u0438\u0442\u0430 \u0410.\u0412., \u0414\u0438\u0431\u0440\u043e\u0432\u0430 \u0415.\u0410., \u0438 \u0434\u0440. \u0412\u0435\u0433\u0435\u0442\u0430\u0442\u0438\u0432\u043d\u044b\u0439 \u0442\u043e\u043d\u0443\u0441 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u043e\u043c \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0443\u0441\u0442\u0430\u043b\u043e\u0441\u0442\u0438: \u044d\u0444\u0444\u0435\u043a\u0442\u044b \u0430\u043a\u0443\u043f\u0443\u043d\u043a\u0442\u0443\u0440\u043d\u043e\u0433\u043e \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u00ab\u041b\u0430\u0435\u043d\u043d\u0435\u043a\u00bb. \u041a\u0440\u0435\u043c\u043b\u0435\u0432\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0435\u0441\u0442\u043d\u0438\u043a. 2008;4:94-6 [Dudnik EN, Kalita AV, Dibrova EA, et al. Vegetativnyi tonus u patsientov s sindromom khronicheskoi ustalosti: effekty akupunkturnogo vvedeniia preparata \"Laennek\". Kremlevskaya meditsina. Klinicheskii vestnik. 2008;4:94-6 (in Russian)]."},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00623"},{"key":"ref40","unstructured":"\u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0417\u0433\u043e\u0434\u0430 \u0412.\u0413., \u0414\u0438\u0431\u0440\u043e\u0432\u0430 \u0415.\u0410. \u0420\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u043d\u043e\u0435 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u043f\u0435\u043f\u0442\u0438\u0434\u043e\u0432 \u041b\u0430\u0435\u043d\u043d\u0435\u043a\u0430 \u043d\u0430 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0435 \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u044b. \u0422\u0435\u0440\u0430\u043f\u0438\u044f. 2017;7:71-84 [Gromova OA, Torshin IYu, Zgoda VG, Dibrova EA. Regulatory action of Laennec peptides on mitochondrial processes. Therapy. 2017;7:71-84 (in Russian)]."},{"key":"ref41","unstructured":"Gromova O.A. Prospective of gerontological applications of Laennec: fundamental studies & molecular mechanisms. Congress of anti-age medicine, plenary session. Tokyo, 2017. Available at: http:\/\/www.jplaa.jp\/images\/pdf\/%E7%A0%94%E7%A9%B6%E8%A6%81%E8%A6%A7_%E7%AC%AC2021%E5%90%88%E4%BD%B5%E5%8F%B7_%E8%A1%A81.pdf. Accessed: 03.02.2022."},{"key":"ref42","unstructured":"\u041b\u0435\u043e\u043d\u043e\u0432 \u0421.\u0412., \u041c\u0430\u0440\u0443\u0441\u0438\u0447 \u0415.\u0418., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0438 \u0434\u0440. \u0410\u043d\u0442\u0438\u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043d\u043e\u0439 \u044d\u0444\u0444\u0435\u043a\u0442 \u0433\u0438\u0434\u0440\u043e\u043b\u0438\u0437\u0430\u0442\u0430 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430: \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442. \u0422\u0435\u0440\u0430\u043f\u0438\u044f. 2017;4:75-83 [Leonov SV, Marusich EI, Gromova OA, et al. Anti-aging effect of human placenta hydrolysate. Evidence-based standard. Therapy. 2017;4:75-83 (in Russian)]."},{"key":"ref43","unstructured":"\u0422\u043e\u0440\u0448\u0438\u043d \u0418., \u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e., \u0414\u0438\u0431\u0440\u043e\u0432\u0430 \u0415., \u0438 \u0434\u0440. \u0412\u043b\u0438\u044f\u043d\u0438\u0435 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u00ab\u041b\u0410\u0415\u041d\u041d\u0415\u041a\u00bb \u043d\u0430 \u043c\u0430\u0440\u043a\u0435\u0440\u044b \u0441\u0442\u0430\u0440\u0435\u043d\u0438\u044f. \u042d\u0441\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 2017;2:157-67 [Torshin I, Gromova O, Dibrova E., et al. Vliyanie preparata \"LAENNEK\" na markery stareniya. Esteticheskaya meditsina. 2017;2:157-67 (in Russian)]."},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00349"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1120882"},{"key":"ref46","unstructured":"\u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u0414\u0438\u0431\u0440\u043e\u0432\u0430 \u0415.\u0410., \u0438 \u0434\u0440. \u0413\u0438\u0434\u0440\u043e\u043b\u0438\u0437\u0430\u0442\u044b \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0432 \u0440\u0435\u043a\u043e\u043d\u0441\u0442\u0440\u0443\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0441\u043e\u0435\u0434\u0438\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438 \u0445\u0440\u044f\u0449\u0430 \u0438 \u0441\u0443\u0441\u0442\u0430\u0432\u043e\u0432. \u0422\u0435\u0440\u0430\u043f\u0438\u044f. 2016;6:43-53 [Gromova OA, Torshin IYu, Dibrova EA, et al. Human placenta hydrolyzates in reconstructive therapy of connective tissue of cartilage and joints. Therapy. 2016;6:43-53 (in Russian)]."},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/s2095-4964(17)60316-9"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.36691\/RJA191"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"\u0415\u043b\u0438\u0441\u044e\u0442\u0438\u043d\u0430 \u041e.\u0413., \u0424\u0435\u0434\u0435\u043d\u043a\u043e \u0415.\u0421., \u0428\u0430\u0431\u0430\u043d\u043e\u0432\u0430 \u0418.\u0424., \u041a\u0430\u0440\u0438\u043c\u043e\u0432\u0430 \u0418.\u041c. \u041f\u0435\u0440\u0432\u044b\u0439 \u043e\u043f\u044b\u0442 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u041b\u0430\u0435\u043d\u043d\u0435\u043a \u043f\u0440\u0438 \u0430\u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0434\u0435\u0440\u043c\u0430\u0442\u0438\u0442\u0435 \u0432 \u0420\u043e\u0441\u0441\u0438\u0438. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0430\u043b\u043b\u0435\u0440\u0433\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2010;1:97-104 [Elisyutina OG, Fedenko ES, Shabanova IF, Karimova I.M. Pervyi opyt primeneniya preparata Laennek pri atopicheskom dermatite v Rossii. Russian Journal of Allergy. 2018;15(1-1):82-90 (in Russian)].","DOI":"10.36691\/RJA924"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.36691\/RJA521"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-021-1367-2"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.31146\/1682-8658-ecg-178-6-55-63"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.08.041"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9979670"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0674"},{"key":"ref56","unstructured":"\u041a\u0443\u0437\u043d\u0435\u0446\u043e\u0432\u0430 \u0418.\u0412., \u0423\u0441\u043f\u0435\u043d\u0441\u043a\u0430\u044f \u042e.\u0411., \u041a\u043e\u0432\u0430\u043b\u0435\u043d\u043a\u043e \u041c.\u0410. \u041e\u043f\u044b\u0442 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0433\u0438\u0434\u0440\u043e\u043b\u0438\u0437\u0430\u0442\u0430 \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u043f\u0440\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u044d\u043d\u0434\u043e\u043c\u0435\u0442\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0438. \u0410\u0440\u0445\u0438\u0432 \u0430\u043a\u0443\u0448\u0435\u0440\u0441\u0442\u0432\u0430 \u0438 \u0433\u0438\u043d\u0435\u043a\u043e\u043b\u043e\u0433\u0438\u0438 \u0438\u043c. \u0412.\u0424. \u0421\u043d\u0435\u0433\u0438\u0440\u0435\u0432\u0430. 2014;1(1):22-4 [Kuznetsova IV, Uspenskaya YuB, Kovalenko MA. The use of human placenta hydrolyzate in the treatment of insufficient endometrial proliferation. Arkhiv akusherstva i ginekologii im. V.F. Snegireva. 2014;1(1):22-4 (in Russian)]."},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"\u041a\u0430\u0442\u043a\u043e\u0432\u0430 \u041d.\u042e., \u0413\u0440\u0435\u0447\u043a\u0430\u043d\u0435\u0432 \u0413.\u041e., \u041a\u0430\u0447\u0430\u043b\u0438\u043d\u0430 \u0422.\u0421., \u0438 \u0434\u0440. \u041b\u0435\u0447\u0435\u043d\u0438\u0435 \u0433\u0438\u043f\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u0430\u0440\u0438\u0430\u043d\u0442\u0430 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u044d\u043d\u0434\u043e\u043c\u0435\u0442\u0440\u0438\u0442\u0430: \u0430\u0440\u0433\u0443\u043c\u0435\u043d\u0442\u0430\u0446\u0438\u044f \u043e\u0442\u043a\u0430\u0437\u0430 \u043e\u0442 \u0430\u043d\u0442\u0438\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0435. 2016;8(4):99-103 [Katkova NYu, Grechkanev GO, Kachalina TS, et al. Treatment of the Hypoplastic Variant of Chronic Endometritis: Arguments Against Antibacterial Therapy. Modern Technologies in Medicine. 2016;8(4):99-103 (in Russian)].","DOI":"10.17691\/stm2016.8.4.13"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/106479\/80908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/106479\/80908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T13:06:15Z","timestamp":1650373575000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/106479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2022.03.201408","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,15]]}}}