{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:34:34Z","timestamp":1740180874825,"version":"3.37.3"},"reference-count":15,"publisher":"Consilium Medicum","issue":"11","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>The article presents a description of a patient with chronic HCV infection and multiple extrahepatic manifestations, which manifested in dynamics and were recorded with a different sequence during 15 years of follow-up. In the patient we observed, the most frequently recorded extrahepatic manifestations were verified: porphyria cutanea tarda, mixed cryoglobulenemia, and utoimmune thyroiditis. Chronic HCV infection is often diagnosed in the presence of psoriasis was assessed as a paraneoplastic disease.<\/jats:p>","DOI":"10.26442\/00403660.2022.11.201935","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T17:13:41Z","timestamp":1672074821000},"page":"1303-1309","source":"Crossref","is-referenced-by-count":0,"title":["Case of multiple systemic (extrahepatic) manifestations of chronic HCV infection (analysis of the literature and own observations). Case report"],"prefix":"10.26442","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-8753","authenticated-orcid":false,"given":"Alexandr B.","family":"Krivosheev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-3385","authenticated-orcid":false,"given":"Liudmila A.","family":"Khvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-7140","authenticated-orcid":false,"given":"Dmitry V.","family":"Morozov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-4983","authenticated-orcid":false,"given":"Inga A.","family":"Krivosheeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-8914","authenticated-orcid":false,"given":"Svetlana V.","family":"Spitsina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-7842","authenticated-orcid":false,"given":"Olga A.","family":"Dobracheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-5815","authenticated-orcid":false,"given":"Svetlana A.","family":"Eremeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-0557","authenticated-orcid":false,"given":"Elena E.","family":"Levekina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref1","unstructured":"\u0428\u0438\u0444\u0444 \u042e.\u0420., \u0421\u043e\u0440\u0435\u043b\u043b \u041c.\u0424., \u041c\u044d\u0434\u0434\u0440\u0435\u0439 \u0423.\u0421. \u0411\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438 \u043f\u043e \u0428\u0438\u0444\u0444\u0443. \u0412\u0438\u0440\u0443\u0441\u043d\u044b\u0435 \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u044b \u0438 \u0445\u043e\u043b\u0435\u0441\u0442\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041f\u0435\u0440. \u0441 \u0430\u043d\u0433\u043b. \u041c.: \u0413\u042d\u041e\u0422\u0410\u0420-\u041c\u0435\u0434\u0438\u0430, 2010 [Schiff ER, Sorrel MF, Maddrey WC. Bolezni pecheni po Shiffu. Virusnye gepatity i kholestaticheskie zabolevaniia. Per. s angl. Moscow: GEOTAR-Media, 2010 (in Russian)]."},{"key":"ref2","unstructured":"\u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0438\u0440\u0443\u0441\u043d\u044b\u0439 \u0433\u0435\u043f\u0430\u0442\u0438\u0442. \u041f\u043e\u0434 \u0440\u0435\u0434. \u0412.\u0412. \u0421\u0435\u0440\u043e\u0432\u0430, \u0417.\u0413. \u0410\u043f\u0440\u043e\u0441\u0438\u043d\u043e\u0439. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 2002 [Khronicheskii virusnyi gepatit. Pod red. VV Serova, ZG Aprosinoi. Moscow: Meditsina, 2002 (in Russian)]."},{"key":"ref3","unstructured":"\u0418\u0433\u043d\u0430\u0442\u043e\u0432\u0430 \u0422.\u041c., \u0421\u0435\u0440\u043e\u0432 \u0412.\u0412., \u041c\u0443\u0445\u0438\u043d \u041d.\u0410., \u0438 \u0434\u0440. HCV-\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f \u0438 \u0441\u043c\u0435\u0448\u0430\u043d\u043d\u0430\u044f \u043a\u0440\u0438\u043e\u0433\u043b\u043e\u0431\u0443\u043b\u0438\u043d\u0435\u043c\u0438\u044f. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 2005;83(6):37-43 [Ignatova TM, Serov VV, Mukhin NA, et al. HCV infection and mixed cryoglobulinemia. Clinical Medicine. 2005;83(6):37-43 (in Russian)]."},{"key":"ref4","unstructured":"\u041a\u0440\u0438\u0432\u043e\u0448\u0435\u0435\u0432 \u0411.\u041d., \u041a\u0443\u0438\u043c\u043e\u0432 \u0410.\u0414., \u041a\u0440\u0438\u0432\u043e\u0448\u0435\u0435\u0432 \u0410.\u0411. \u0417\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u0432\u043d\u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0445 \u043e\u0440\u0433\u0430\u043d\u043e\u0432 \u043f\u0440\u0438 \u043c\u0430\u043d\u0438\u0444\u0435\u0441\u0442\u043d\u044b\u0445 \u0438 \u043b\u0430\u0442\u0435\u043d\u0442\u043d\u044b\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u0445 \u043f\u043e\u0440\u0444\u0438\u0440\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u043e\u0431\u043c\u0435\u043d\u0430. \u041c.: \u0418\u041d\u0424\u0420\u0410-\u041c, 2018 [Krivosheev BN, Kuimov AD, Krivosheev AB. Zabolevaniia vnutrennikh organov pri manifestnykh i latentnykh narusheniia porfirinovogo obmena. Moscow: INFRA-M, 2018 (in Russian)]."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.31146\/1682-8658-ecg-182-10-96-100"},{"key":"ref6","unstructured":"\u041c\u0430\u043b\u044c\u043a\u043e\u0432 \u041f.\u0413., \u0414\u0430\u043d\u0438\u043b\u043e\u0432\u0430 \u041d.\u0412., \u041c\u043e\u0441\u043a\u0432\u0438\u043d\u0430 \u041b.\u0412. \u0412\u043d\u0435\u043f\u0435\u0447\u0435\u043d\u043e\u0447\u043d\u044b\u0435 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0421 (\u041e\u0431\u0437\u043e\u0440). \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2012;84(11):22-7 [Malkov PG, Danilova NV, Moskvina LV. Extrahepatic complications of chronic viral hepatitis C (Review). Terapevticheskii Arkhiv (Ter. Arkh.). 2012;84(11):22-7 (in Russian)]."},{"key":"ref7","unstructured":"\u0422\u0440\u043e\u0444\u0438\u043c\u043e\u0432 \u0413.\u0410., \u0421\u043c\u0438\u0440\u043d\u043e\u0432 \u0412.\u0421., \u041a\u043e\u043d\u0435\u0432 \u0410.\u0412. \u041e\u0431 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u0438 \u043f\u043e\u0437\u0434\u043d\u0435\u0439 \u043a\u043e\u0436\u043d\u043e\u0439 \u043f\u043e\u0440\u0444\u0438\u0440\u0438\u0438 \u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043a\u0430\u043f\u0438\u043b\u043b\u044f\u0440\u043e\u0442\u043e\u043a\u0441\u0438\u043a\u043e\u0437\u043e\u043c. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 1989;67(4):103-4 [Trofimov GA, Smirnov VS, Konev VA. About the complications of porphyria cutanea tarda hemorrhagic capillaroscope. Clinical Medicine. 1989;67(4):103-4 (in Russian)]."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.25208\/0042-4609-2015-91-4-90-94"},{"key":"ref9","unstructured":"\u0414\u0435\u0434\u043a\u043e\u0432\u0430 \u0415.\u041c., \u0420\u0430\u0431\u0435\u043d \u0410.\u0421. \u041f\u0430\u0440\u0430\u043d\u0435\u043e\u043f\u043b\u0430\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 1977 [Dedkova EM, Raben AS. Paraneoplasticheskie zabolevaniia. 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Arkh.). 2014;86(4):108-16 (in Russian)].","DOI":"10.17116\/terarkh201486125-9"},{"key":"ref11","unstructured":"\u041a\u0440\u0438\u0432\u043e\u0448\u0435\u0435\u0432 \u0410.\u0411., \u041a\u043e\u043d\u0434\u0440\u0430\u0442\u043e\u0432\u0430 \u041c.\u0410., \u041a\u0440\u0438\u0432\u043e\u0448\u0435\u0435\u0432\u0430 \u0422.\u0410., \u0438 \u0434\u0440. \u0421\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u043f\u043e\u0440\u0444\u0438\u0440\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u043e\u0431\u043c\u0435\u043d\u0430 \u043f\u0440\u0438 \u0446\u0438\u0440\u0440\u043e\u0437\u0430\u0445 \u043f\u0435\u0447\u0435\u043d\u0438. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2013;85(1):48-55 [Krivosheev AB, Kondratova MA, Krivosheeva TA, et al. The state of porphyrin metabolism in cirrhosis of the liver. Terapevticheskii Arkhiv (Ter. Arkh.). 2013;85(1):48-55 (in Russian)]."},{"key":"ref12","unstructured":"\u041f\u0430\u0432\u043b\u043e\u0432 \u0410.\u0418., \u0425\u0430\u0437\u0430\u043d\u043e\u0432 \u0410.\u0418., \u041f\u043b\u044e\u0441\u043d\u0438\u043d \u0421.\u0412., \u0438 \u0434\u0440. \u042d\u0442\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u043f\u0440\u0435\u0434\u0440\u0430\u043a\u043e\u0432\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u043f\u0435\u0447\u0435\u043d\u0438 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0433\u0435\u043f\u0430\u0442\u043e\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u043e\u0439 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u043e\u0439 \u0438 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u0433\u0440\u0443\u043f\u043f\u044b \u0440\u0438\u0441\u043a\u0430. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438, \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2008;18(6):51-6 [Pavlov AI, Khazanov AI, Plyusnin SV, et al. Etiology of precancerous liver diseases in patients with hepatocellular carcinoma and some expansion of the risk group. Russian Journal of Gastroenterology, Hepatology, and Coloproctology. 2008;18(6):51-6 (in Russian)]."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.160"},{"key":"ref14","unstructured":"\u0422\u0438\u0445\u043e\u043d\u043e\u0432 \u0418.\u041d., \u041f\u0430\u0432\u043b\u043e\u0432 \u0427.\u0421., \u041c\u0430\u0435\u0432\u0441\u043a\u0430\u044f \u041c.\u0412., \u0418\u0432\u0430\u0448\u043a\u0438\u043d \u0412.\u0422. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043f\u043e\u0434\u0445\u043e\u0434\u044b \u043a \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433\u0443 \u0438 \u0440\u0430\u043d\u043d\u0435\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0433\u0435\u043f\u0430\u0442\u043e\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u043e\u0439 \u043a\u0430\u0440\u0446\u0438\u043d\u043e\u043c\u044b. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430\u044f O\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u044f. 2014;16(3):65-74 [Tikhonov IN, Pavlov ChS, Mayevskaya MV, Ivashkin VT. Modern approaches to screening and early diagnosis of hepatocellular carcinoma. Modern Oncology. 2014;16(3):65-74 (in Russian)]."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.22416\/1382-4376-2019-29-5-53-74"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/119988\/94754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/119988\/94754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T17:14:31Z","timestamp":1672074871000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/119988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,12,26]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2022.11.201935","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}