{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T15:03:22Z","timestamp":1743606202367,"version":"3.37.3"},"reference-count":10,"publisher":"Consilium Medicum","issue":"12","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To study the vasoprotective effects of atorvastatin depending on the achievement of the target level of low-density lipoprotein cholesterol (LDL-C) in patients with ST-segment elevation myocardial infarction (STEMI) within 48 weeks of follow-up.\r\nMaterials and methods. Included were 112 STEMI patients who received atorvastatin 204080 mg. On days 79 from the onset of the disease, after 24 and 48 weeks, ultrasound examination of the carotid arteries with RF technology and applanation tonometry were performed, the lipid profile was determined. The patients were divided into groups: group 1 (n=41) of highly effective therapy (HET)  who achieved the target LDL-C after 24 and 48 weeks; group 2 (n=29) in relatively effective therapy (RET)  achieving target values at 24th or 48th week; group 3 (n=42) insufficiently effective therapy (IET)  did not reach the target LDL-C.\r\nResults. When examining the carotid arteries in the HET group, the intima-media thickness (IMT) decreased by 10.713.1%, the b index  by 14.926.3% after 2448 weeks. In the RET group, the IMT regression was 10.413.3%; b index  23.9% by the 48th week. In the IET group, the b index decreased by the 48th week by 14.3%. According to applanation tonometry in the HET group, the central pressure did not change. In the RET group, systolic pressure in the aorta increased by 1015.7% after 2448 weeks, pulse pressure  by 33.9% by the end of observation. With IET, the increase was 8.66.8 and 19.825.9%, respectively. The odds ratio of developing endpoints in the RET group was 4.7 (95% CI 1.226.4; p=0.02), in the IET group  3.9 (95% CI 1.124.8; p=0.03) compared with HET.\r\nConclusion. The most pronounced vasoprotective effect and a decrease in cardiovascular risk are associated with the achievement of the target LDL-C throughout the entire treatment period.<\/jats:p>","DOI":"10.26442\/00403660.2022.12.202007","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T09:09:54Z","timestamp":1673860194000},"page":"1355-1360","source":"Crossref","is-referenced-by-count":1,"title":["Vasoprotective effect of effective lipid-lowering therapy in patients with &lt;i&gt;ST&lt;\/i&gt;-segment elevation myocardial infarction"],"prefix":"10.26442","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-0316","authenticated-orcid":false,"given":"Ludmila I.","family":"Salyamova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-6620","authenticated-orcid":false,"given":"Angelina A.","family":"Khromova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7008-6995","authenticated-orcid":false,"given":"Olga G.","family":"Kvasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-5900","authenticated-orcid":false,"given":"Irina V.","family":"Avdeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-9457","authenticated-orcid":false,"given":"Natalia A.","family":"Borisova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-0937","authenticated-orcid":false,"given":"Karina N.","family":"Korenkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-4638","authenticated-orcid":false,"given":"Kristina N.","family":"Polezhaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-9259","authenticated-orcid":false,"given":"Valentin E.","family":"Oleynikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.34687\/2219-8202.JAD.2020.01.0002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.15829\/1560-4071-2020-4103"},{"key":"ref3","unstructured":"\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u044f \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u043b\u0438\u043f\u0438\u0434\u043d\u043e\u0433\u043e \u043e\u0431\u043c\u0435\u043d\u0430 \u0441 \u0446\u0435\u043b\u044c\u044e \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 IV \u043f\u0435\u0440\u0435\u0441\u043c\u043e\u0442\u0440. \u041c., 2009 [Diagnostika i korrektsiia narushenii lipidnogo obmena s tsel'iu profilaktiki i lecheniia ateroskleroza. Rossiyskiie rekomendatsii IV peresmotr. Moscow, 2009 (in Russian)]."},{"key":"ref4","unstructured":"\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u044f \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u043b\u0438\u043f\u0438\u0434\u043d\u043e\u0433\u043e \u043e\u0431\u043c\u0435\u043d\u0430 \u0441 \u0446\u0435\u043b\u044c\u044e \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0438 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 V \u043f\u0435\u0440\u0435\u0441\u043c\u043e\u0442\u0440. \u041c., 2012 [Diagnostika i korrektsiia narushenii lipidnogo obmena s tsel'iu profilaktiki i lecheniia ateroskleroza. Rossiyskiie rekomendatsii V peresmotr. Moscow, 2012 (in Russian)]."},{"key":"ref5","unstructured":"\u041f\u0440\u0438\u043a\u0430\u0437 \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0438 \u0441\u043e\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438 \u043e\u0442 6 \u0441\u0435\u043d\u0442\u044f\u0431\u0440\u044f 2005 \u0433. \u2116548 \u00ab\u041e\u0431 \u0443\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u0438 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438 \u0431\u043e\u043b\u044c\u043d\u044b\u043c \u0441 \u043e\u0441\u0442\u0440\u044b\u043c \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u043e\u043c \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430\u00bb. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: http:\/\/www.consultant.ru\/cons\/cgi\/online.cgi?req=doc&base=EXP&n=411152&dst=100001#AktPgeSbxtOmUGFM. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 14.09.2021 [Order of the Ministry of Health and Social Development of the Russian Federation dated September 6, 2005 No. 548 \u201cOn approval of the standard of medical care for patients with acute myocardial infarction\u201d. 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Accessed: 14.09.2021 (in Russian)]."},{"key":"ref6","unstructured":"\u041f\u0440\u0438\u043a\u0430\u0437 \u041c\u0438\u043d\u0437\u0434\u0440\u0430\u0432\u0430 \u0420\u043e\u0441\u0441\u0438\u0438 \u043e\u0442 01.07.2015 \u2116404\u0430\u043d \u00ab\u041e\u0431 \u0443\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u0438\u0438 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u0430 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043f\u043e\u043c\u043e\u0449\u0438 \u043f\u0440\u0438 \u043e\u0441\u0442\u0440\u043e\u043c \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0435 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 (\u0441 \u043f\u043e\u0434\u044a\u0435\u043c\u043e\u043c \u0441\u0435\u0433\u043c\u0435\u043d\u0442\u0430 ST \u044d\u043b\u0435\u043a\u0442\u0440\u043e\u043a\u0430\u0440\u0434\u0438\u043e\u0433\u0440\u0430\u043c\u043c\u044b)\u00bb (\u0417\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043d\u043e \u0432 \u041c\u0438\u043d\u044e\u0441\u0442\u0435 \u0420\u043e\u0441\u0441\u0438\u0438 20.07.2015 \u211638092). \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: http:\/\/www.consultant.ru\/document\/cons_doc_LAW_183746\/ \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 14.09.2021 [Order of the Ministry of Health of Russia dated 01.07.2015 \u2116 404an \u201cOn approval of the standard of specialized medical care for acute myocardial infarction (with an increase in the ST segment of the electrocardiogram)\u201d (Registered in the Ministry of Justice of Russia on 20.07.2015 \u211638092). 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Russian recommendations VI revision. Journal of Atherosclerosis and Dyslipidemias. 2017;3(28):5-22 (in Russian)]."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308537"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008226.pub3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.15829\/1728-8800-2016-2-4-19"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/77531\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/77531\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T09:14:37Z","timestamp":1673860477000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/77531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,1,16]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2022.12.202007","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2023,1,16]]}}}