{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T11:06:15Z","timestamp":1749467175013,"version":"3.37.3"},"reference-count":13,"publisher":"Consilium Medicum","issue":"2","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Background. Despite the well-studied pathogenesis, the etiology of autoimmune liver disease (AILD) remains unknown.\r\nAim. To determine the significance of hepatitis A, B, C and E viruses in the development and progression of AILD.\r\nMaterials and methods. A single-center case-control study included 139 patients with AILD: autoimmune hepatitis  AIH (n=46), primary biliary cholangitis  PBS (n=74), primary sclerosing cholangitis  PSC (n=19). Median age 56 years, IQR 4865 years. 125 patients  without liver disease  control group (median age 55 years, IQR 4665 years). Testing of blood serum samples for anti-HAV IgG, anti-HEV IgG, HBsAg, anti-HBc IgG, anti-HCV was carried out by solid-phase ELISA. All patients underwent fibroelastography. Needle liver biopsy  70 patients: AIH (n=37), PBC (n=28) and PSC (n=5).\r\nResults. Ab(IgG) to HAV and HBV were detected in patients with AILD significantly more often than in the control group (74.8% vs 54.4%; p0.001). An increased risk of developing AILD was established in patients with the presence of antibodies to HAV, HBV and HEV (OR 2.491, CI 95% [1.4814.190]). The highest risk of developing PBC was found in patients with antibodies to HAV and HBV (OR 3.008, 95% CI [1.6335.542] and OR 2.515, 95% CI [1.2425.093]). In patients with severe liver fibrosis (F3F4 according to METAVIR), antibodies to HAV and HBV were detected significantly more often than in patients with F0F2 [85% vs 65%; p=0.008].\r\nConclusion. In our work, we have demonstrated the relationship of past hepatitis A, B, E and AILD, as well as the high risk of developing severe fibrosis in patients with AILD and markers of hepatitis A and B viruses indicates the possible involvement of these viruses in the pathogenesis of AILD.<\/jats:p>","DOI":"10.26442\/00403660.2023.02.202113","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T13:54:50Z","timestamp":1680184490000},"page":"173-178","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of the possible impact of hepatitis viruses on the development and course of autoimmune liver diseases"],"prefix":"10.26442","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-9643","authenticated-orcid":false,"given":"Evgeniya S.","family":"Sbikina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-8375","authenticated-orcid":false,"given":"Elena V.","family":"Vinnitskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-203X","authenticated-orcid":false,"given":"Sergey N.","family":"Batskikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-812X","authenticated-orcid":false,"given":"Yuliay G.","family":"Sandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-7052","authenticated-orcid":false,"given":"Kirill G.","family":"Saliev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4599-4040","authenticated-orcid":false,"given":"Tatyana Yu.","family":"Khaimenova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-3992","authenticated-orcid":false,"given":"Dmitry S.","family":"Bordin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322362"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.05.061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-03535-8_1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.18565\/epidem.2019.9.1.71-80"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v6.i13.589"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw406"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026645629103"},{"key":"ref8","unstructured":"Rahaman SM, Chira P, Koff RS. Idiopathic autoimmune chronic hepatitis triggered by hepatitis A. Am J Gastroenterol. 1994;89:106-8."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.111864"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000441"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i38.6069"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92858-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.016"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/321754\/113269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/321754\/113269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T13:55:04Z","timestamp":1680184504000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/321754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,3,30]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2023.02.202113","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}