{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:28:30Z","timestamp":1769927310373,"version":"3.49.0"},"reference-count":47,"publisher":"Consilium Medicum","issue":"3","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Chronic kidney disease (CKD) is one of the most common complications of diabetes mellitus and an independent risk factor for cardiovascular disease. Despite guideline-directed therapy of CKD in patients with type 2 diabetes, the risk of renal failure and cardiovascular events still remains high. To date, current medications for CKD havent reduced enough the residual risk associated with inflammation and fibrosis in patients with type 2 diabetes. Here, in this review we present the results of FIDELIO-DKD, FIGARO-DKD trials and their pooled analysis FIDELITY, aimed to evaluate the effectiveness and safety of selective non-steroidal mineralocorticoid receptor antagonist finerenone in patients with type 2 diabetes with wide range stages of CKD. Modern pathophysiological aspects of mineralocorticoid receptor hyperactivation and features of their blockade by steroidal and nonsteroidal mineralocorticoid receptor antagonists are considered, differences in pharmacological effects between them are also discussed, finerenone benefits and its adverse events, demonstrated in randomized clinical trials are considered here. The probable mechanisms of early and delayed action of finerenone, which were realized in beneficial cardiovascular and renal outcomes in patients with type 2 diabetes with CKD, are presented here. Practical points for finerenone initiation and titration are indicated, aimed to minimize the hyperkalemia risk. Current guidelines for CKD treatment in patients with type 2 diabetes are analyzed, the finerenone placement in combined nephroprotective therapy is determined.<\/jats:p>","DOI":"10.26442\/00403660.2023.03.202152","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T18:58:48Z","timestamp":1682535528000},"page":"261-273","source":"Crossref","is-referenced-by-count":4,"title":["Finerenone cardiorenal effects and its placement in treatment of chronic kidney disease in patients with type 2 diabetes mellitus: A review"],"prefix":"10.26442","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-0941","authenticated-orcid":false,"given":"Vladimir V.","family":"Salukhov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-0142","authenticated-orcid":false,"given":"Minara S.","family":"Shamkhalova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-0845","authenticated-orcid":false,"given":"Alla V.","family":"Duganova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.06.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61350-6"},{"key":"ref3","unstructured":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u043e\u0447\u0435\u043a (\u0425\u0411\u041f). \u041d\u0435\u0444\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2021;25(5):10-82 [Clinical recommendations. Chronic kidney disease (CKD). Nephrology (Saint-Petersburg). 2021;25(5):10-82 (in Russian)]."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13917"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14341\/DM12123"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.14341\/DM12286"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.21518\/2079-701X-2022-16-10-10-21"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007004.pub3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.12.002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000515622"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.14341\/DM12944"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.48"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1123-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105859"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-060821-013950"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2022.2094770"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002043RR"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Abedini A, Wu J, Ma Z, et al. Revealing the antifibrotic mechanism of finerenone in the DOCA-salt nephropathy rat model using single nuclei and bulk transcriptomics. 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FIDELITY: Effect of finerenone by LVH subgroup. LBT Pharmacological treatment II, Heart Failure 2022, 21\u201324 May, Madrid, Spain. Available at: https:\/\/conferences.medicom-publishers.com\/specialisation\/cardiology\/hfa-2022\/fidelity-cardiorenal-benefits-of-finerenone-regardless-of-lvh-status-2\/ Accessed: 09.06.2022.","DOI":"10.55788\/5738a863"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S011"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.08.002"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05787-2"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021070942"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S325916"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.360"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1159\/000516213"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00551.2017"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa736"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/346685\/118483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/346685\/118483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T07:44:05Z","timestamp":1729323845000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/346685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,4,26]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2023.03.202152","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,26]]}}}