{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:33:03Z","timestamp":1771543983763,"version":"3.50.1"},"reference-count":21,"publisher":"Consilium Medicum","issue":"5","license":[{"start":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T00:00:00Z","timestamp":1689465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Background. In Russia, as well as throughout the world, the use of glucocorticoids (GC) in the treatment of rheumatoid arthritis (RA) is widespread, often going beyond the recommendations for both duration and dose regimen, which makes it relevant to study the long-term consequences of such a wrong (EULAR, 2022) use of GC in RA therapy.\r\nMaterials and methods. Of 1143 patients with active RA (ACR\/EULAR 2010), two groups were formed: A (n=782) RA patients with more than 6 months of experience with systemic GC; group B (n=245)  no experience of taking GC. The cumulative disease index (CIRS) was used to assess the comorbidity profile.\r\nResults. Patients in group A were older (p0.0001), with a longer duration of RA (p=0.0004) and more often with IV radiological stage (p=0.02). With comparable (DAS28) RA activity, the D2T variant of RA was more often detected in them (p=0.036). RA therapy in group A was characterized by a large number of used disease-modifying anti-rheumatic drugs (p=0.0003), more frequent development of methotrexate-induced hepatitis (p=0.03). In group A, the time interval between the onset of RA and the initiation of biological therapy was longer (p=0.0001) and directly correlated with the duration of GC therapy (Rs=0.38) with a comparable qualitative structure of the used b\/tsDMARDs. In the same group, tuberculosis, hypertension, chronic kidney disease, cataract and osteoporosis (p0.05) and its complications were diagnosed significantly more often with a comparable frequency of cardiovascular disease, diabetes, and gastrointestinal lesions. In group A, a higher CIRS multimorbidity index was detected, and the CIRS severity index was lower than in group B (p0.05).\r\nConclusion. Long-term use of GC did not lead to a decrease in disease activity, inhibition of radiographic progression, delayed the timely administration of b\/tsDMARDS and was accompanied by an increase in the multimorbid load.<\/jats:p>","DOI":"10.26442\/00403660.2023.05.202196","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T20:39:55Z","timestamp":1689539995000},"page":"380-385","source":"Crossref","is-referenced-by-count":5,"title":["Long-term use of glucocorticoids in patients with active rheumatoid arthritis: therapeutic \"freeze frame\""],"prefix":"10.26442","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-8851","authenticated-orcid":false,"given":"Andrey V.","family":"Gordeev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-5524","authenticated-orcid":false,"given":"Elena V.","family":"Matyanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena A.","family":"Galushko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2023,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1415"},{"key":"ref2","unstructured":"Hench PS, Kendall EC, Slocumb CH, Polley HF. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff. Meet. Mayo Clin. 1949;24:181-97."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208916"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"\u041d\u0430\u0441\u043e\u043d\u043e\u0432 \u0415.\u041b. \u041d\u043e\u0432\u044b\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430 (EULAR, 2013): \u043c\u0435\u0441\u0442\u043e \u0433\u043b\u044e\u043a\u043e\u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0438\u0434\u043e\u0432. \u041d\u0430\u0443\u0447\u043d\u043e-\u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2016;54:37-49 [Nasonov EL. New guidelines for the management of rheumatoid arthritis (EULAR, 2013): The place of glucocorticoids. Rheumatology Science and Practice. 2016;54:37-49 (in Russian)].","DOI":"10.14412\/1995-4484-2015-238-250"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14412\/1996-7012-2014-2-28-34"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006356"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223358"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0370-z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223356"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"\u041d\u0430\u0441\u043e\u043d\u043e\u0432 \u0415.\u041b. \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0430\u0440\u0442\u0440\u0438\u0442\u0430: \u0440\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0435 \u0438 \u043c\u0435\u0436\u0434\u0443\u043d\u0430\u0440\u043e\u0434\u043d\u044b\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u041d\u0430\u0443\u0447\u043d\u043e-\u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2016;54(5):557-71 [Nasonov EL. Pharmacotherapy for rheumatoid arthritis: Russian and International guidelines. Rheumatology Science and Practice. 2016;54(5):557-71 (in Russian)].","DOI":"10.14412\/1995-4484-2016-557-571"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(92)90005"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"\u0413\u043e\u0440\u0434\u0435\u0435\u0432 \u0410.\u0412., \u0413\u0430\u043b\u0443\u0448\u043a\u043e \u0415.\u0410., \u0421\u0430\u0432\u0443\u0448\u043a\u0438\u043d\u0430 \u041d.\u041c., \u0438 \u0434\u0440. \u041e\u0446\u0435\u043d\u043a\u0430 \u043c\u0443\u043b\u044c\u0442\u0438\u043c\u043e\u0440\u0431\u0438\u0434\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0444\u0438\u043b\u044f (CIRS) \u043f\u0440\u0438 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u0435. \u041f\u0435\u0440\u0432\u044b\u0435 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2019;13(3):10-6 [Gordeev AV, Galushko EA, Savushkina NM, et al. Assessing the multimorbid profile (CIRS) in rheumatoid arthritis. First results. Modern Rheumatology Journal. 2019;13(3):10-6 (in Russian)]. DOI:10\/14412\/1996-7012-2019-3-10-16","DOI":"10.14412\/1996-7012-2019-3-10-16"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"\u0424\u043e\u043b\u043e\u043c\u0435\u0435\u0432\u0430 \u041e.\u041c., \u041d\u0430\u0441\u043e\u043d\u043e\u0432 \u0415.\u041b., \u0410\u043d\u0434\u0440\u0438\u0430\u043d\u043e\u0432\u0430 \u0418.\u0410., \u0438 \u0434\u0440. \u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0430\u0440\u0442\u0440\u0438\u0442 \u0432 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435 \u0420\u043e\u0441\u0441\u0438\u0438: \u0442\u044f\u0436\u0435\u0441\u0442\u044c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0432 \u0440\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u043f\u043e\u043f\u0443\u043b\u044f\u0446\u0438\u0438 \u0431\u043e\u043b\u044c\u043d\u044b\u0445. \u041e\u0434\u043d\u043e\u043c\u043e\u043c\u0435\u043d\u0442\u043d\u043e\u0435 (\u043f\u043e\u043f\u0435\u0440\u0435\u0447\u043d\u043e\u0435) \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 (RAISER). \u041d\u0430\u0443\u0447\u043d\u043e-\u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2010;48(1):50-60 [Folomeeva OM, Nasonov EL, Andrianova IA, et al. Rheumatoid arthritis in rheumatological practice in Russia: the severity of the disease in the Russian patient population. Single-stage (cross-sectional) epidemiological study (RAISER). Rheumatology Science and Practice. 2010;48(1):50-60 (in Russian)].","DOI":"10.14412\/1995-4484-2010-1406"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211187"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210135"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-015-0019-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1461-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002387"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217344"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30636-X"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/551819\/132626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/551819\/132626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T07:07:06Z","timestamp":1689577626000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/551819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,16]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,7,16]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2023.05.202196","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,16]]}}}