{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:07:41Z","timestamp":1789704461002,"version":"4.0.1"},"reference-count":34,"publisher":"Consilium Medicum","issue":"8","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To evaluate the efficacy of seven-day treatment with rabeprazole (Razo\u00ae) 20 mg once daily in patients with NERD and esophagitis based on monitoring the results of pH-impedancemetry of the stomach and esophagus and assessment of clinical symptoms.\r\nMaterials and methods. Thirty patients with typical GERD manifestations were examined. The study included patients who underwent pH-impedancemetry, endoscopic examination, and were prescribed treatment with rabeprazole at a dose of 20 mg once a day. Clinical monitoring was performed during three visits: before treatment, after 3 days, and after 7 days of treatment. Control pH-impedancemetry was performed after 7 days of therapy. The third visit was the endpoint of the study.\r\nResults. After 7 days of treatment, the response rate for heartburn was 86.7% in the overall group of patients with GERD, 94.4% in those with NERD, and 75.0% in patients with esophagitis stage A and B. After 7 days of therapy with rabeprazole, we registered a significant decrease in the total number of refluxes (from 88 to 54; p0.001), the number of acid refluxes (from 53 to 22; p0.001), the DeMeester index (from 23.81 to 7.62; p0.001), and AET (from 7.54 to 2.01; p0.001) in the esophagus and an increase in the median daily pH (from 1.8 to 5.4; p0.001) and the time with pH4 in the stomach (from 2.57 hours and 10.7% up to 12.3 hours and 51.3%; p0.001). 7-day therapy with rabeprazole was accompanied by a significant improvement in GERD patients in all parameters of quality of life. 100% of patients with GERD rated their satisfaction with therapy as \u201cgood\u201d and \u201cvery good\u201d.\r\nConclusion. As a result of 7-day therapy of patients with NERD and esophagitis with Razo\u00ae at a dose of 20 mg per day, an excellent clinical response was obtained, confirmed by a marked optimization of pH-impedancemetry parameters.<\/jats:p>","DOI":"10.26442\/00403660.2024.08.202895","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:03:04Z","timestamp":1726272184000},"page":"804-811","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of rabeprazole for the treatment of gastroesophageal reflux disease in a 7-day non-interventional trial"],"prefix":"10.26442","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-2294","authenticated-orcid":false,"given":"Vladislav V.","family":"Tsukanov","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cKrasnoyarsk Science Center\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-6639","authenticated-orcid":false,"given":"Elena V.","family":"Onuchina","sequence":"additional","affiliation":[{"name":"Irkutsk State Medical Academy of Postgraduate Education \u2013 Branch of the Russian Medical Academy of Continuous Professional Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-3196","authenticated-orcid":false,"given":"Alexander V.","family":"Vasyutin","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cKrasnoyarsk Science Center\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairma B.","family":"Dambaeva","sequence":"additional","affiliation":[{"name":"Irkutsk State Medical Academy of Postgraduate Education \u2013 Branch of the Russian Medical Academy of Continuous Professional Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-1895","authenticated-orcid":false,"given":"Julia L.","family":"Tonkikh","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cKrasnoyarsk Science Center\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-8707","authenticated-orcid":false,"given":"Nadezhda V.","family":"Pavlova","sequence":"additional","affiliation":[{"name":"Dr. Reddy\u2019s Laboratories Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2019.02.000099"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh201688228-32"},{"key":"ref3","unstructured":"\u0426\u0443\u043a\u0430\u043d\u043e\u0432 \u0412.\u0412., \u041e\u043d\u0443\u0447\u0438\u043d\u0430 \u0415.\u0412., \u0412\u0430\u0441\u044e\u0442\u0438\u043d \u0410.\u0412., \u0438 \u0434\u0440. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u0441\u043f\u0435\u043a\u0442\u044b \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u0437\u043e\u0444\u0430\u0433\u0430\u043b\u044c\u043d\u043e\u0439 \u0440\u0435\u0444\u043b\u044e\u043a\u0441\u043d\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u0443 \u043b\u0438\u0446 \u043f\u043e\u0436\u0438\u043b\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430: \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b 5-\u043b\u0435\u0442\u043d\u0435\u0433\u043e \u043f\u0440\u043e\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2014;86(2):23-6. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/31425. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 20.08.2024 [Tsukanov VV, Onuchina EV, Vasiutin AV, et al. 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