{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:15:06Z","timestamp":1790140506642,"version":"4.0.1"},"reference-count":43,"publisher":"Consilium Medicum","issue":"2","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To systematize data on the prevalence and risk of malnutrition in patients with chronic pancreatitis (CP).\r\nMaterials and methods. MEDLINE\/PubMed, EMBASE, Cochrane, Google Scholar, Scopus, and the Russian Science Citation Index were searched for studies published between January 1, 1985, and October 23, 2024 (inclusive) based on an analysis of the titles and abstracts of articles in these databases. The study included relevant publications in peer-reviewed periodicals in English or Russian, publications with data on the prevalence of malnutrition in patients with CP and control subjects (if any), studies on adult patients with CP, and publications with detailed descriptive statistics that allow using the data in the meta-analysis.\r\nResults. The final analysis included 13 studies involving 3,812 subjects (3,401 patients with CP and 411 controls). The overall prevalence of malnutrition in patients with CP was 43.43% (95% confidence interval [CI] 32.419\u201354.780), whereas in controls, it was 10.843% (95% CI 1.360\u201327.698). When analyzing the association in the overall pool of studies, a significant risk of malnutrition in CP patients compared to controls was shown (relative risk [RR] 3.635, 95% CI 1.409\u20139.373; p=0.008). The analysis used a random effect model, as there was high heterogeneity between the groups (I2=88.09%, 95% CI 74.76\u201394.38). A review of studies that used only validated instrumental methods for the diagnosis of malnutrition (criteria of the Global Leadership Initiative on Malnutrition) showed a total prevalence of malnutrition of 38.348% (95% CI 14.975\u201365.047) in patients with CP and 12.22% (95% CI 5.985\u201367.238) in control subjects.\r\nConclusion. This meta-analysis demonstrated that malnutrition is a common complication of CP and occurs in approximately 40% of CP patients. A modern clinician should promptly assess malnutrition markers in a CP patient and correct them using enzyme replacement therapy if detected.<\/jats:p>","DOI":"10.26442\/00403660.2025.02.203192","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:30:05Z","timestamp":1742967005000},"page":"185-192","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and risk of malnutrition in patients with chronic pancreatitis: A systematic review and meta-analysis"],"prefix":"10.26442","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-7112","authenticated-orcid":false,"given":"Dmitry N.","family":"Andreev","sequence":"additional","affiliation":[{"name":"Russian University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4358-7823","authenticated-orcid":false,"given":"Alsu R.","family":"Khurmatullina","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7760-2091","authenticated-orcid":false,"given":"Yury A.","family":"Kucheryavyy","sequence":"additional","affiliation":[{"name":"Ilyinsky Hospital JSC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-564X","authenticated-orcid":false,"given":"Igor V.","family":"Maev","sequence":"additional","affiliation":[{"name":"Russian University of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616684695"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0087-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.42"},{"key":"ref4","unstructured":"Seicean A, Grigorescu M, Tan\u0163\u0103u M, et al. Pain in chronic pancreatitis: Assessment and relief through treatment. Rom J Gastroenterol. 2004;13(1):9-15. PMID:15054520"},{"key":"ref5","unstructured":"Ghodeif AO, Azer SA. Pancreatic Insufficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2024. Available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK555926\/ Accessed: 05.09.2024."},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.6000\/1929-5634.2014.03.03.3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065946"},{"key":"ref8","unstructured":"\u041c\u0430\u0435\u0432 \u0418.\u0412., \u041a\u0443\u0447\u0435\u0440\u044f\u0432\u044b\u0439 \u042e.\u0410. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043f\u043e\u0434\u0445\u043e\u0434\u044b \u043a \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0442\u0438\u0442\u0430. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 2013;91(9):10-6 [Maev IV, Kucheriavyi IuA. Modern approaches to diagnostics and treatment of chronic pancreatitis. Klinicheskaia Meditsina. 2013;91(9):10-6 (in Russian)]."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh2017892105-113"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12300"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000623"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2020.12.200430"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.47360\/1995-4484-2021-56-61"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05459.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.040"},{"key":"ref16","unstructured":"Sathiaraj E, Gupta S, Chutke M, et al. Malnutrition is not an etiological factor in the development of tropical pancreatitis \u2013 A case-control study of southern Indian patients. Trop Gastroenterol. 2010;31(3):169-74. PMID: 21560520"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-011-0093-9"},{"key":"ref18","unstructured":"\u041a\u0443\u0447\u0435\u0440\u044f\u0432\u044b\u0439 \u042e.\u0410., \u041c\u043e\u0441\u043a\u0430\u043b\u0435\u0432\u0430 \u0410.\u0411., \u0421\u0432\u0438\u0440\u0438\u0434\u043e\u0432\u0430 \u0410.\u0412., \u0438 \u0434\u0440. \u041d\u0443\u0442\u0440\u0438\u0442\u0438\u0432\u043d\u044b\u0439 \u0441\u0442\u0430\u0442\u0443\u0441 \u043a\u0430\u043a \u0444\u0430\u043a\u0442\u043e\u0440 \u0440\u0438\u0441\u043a\u0430 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u0439 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0442\u0438\u0442\u0430 \u0438 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0438. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2012;7:10-6 [Kucheryavyy YuA, Moskaleva AB, Sviridova AV, et al. Nutritional status as a risk factor for complications of chronic pancreatitis and the development of pancreatic insufficiency. Experimental and Clinical Gastroenterology. 2012;7:10-6 (in Russian)]."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.18786\/2072-0505-2019-47-065"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.03.038"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.02.012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.02.004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/cdt3.48"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2022.111887"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.09.166"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-54998-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12383"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110361910"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.004"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.11.006"},{"key":"ref31","unstructured":"Duggan SN, Conlon KC. A practical guide to the nutritional management of chronic pancreatitis. Pract Gastroenterol. 2013;118:24-32."},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/nu16071069"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12185"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2019.01.006"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2020.01.000488"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.07.007"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21659"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312529"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620938987"},{"key":"ref40","unstructured":"\u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043f\u0430\u043d\u043a\u0440\u0435\u0430\u0442\u0438\u0442. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. 2024. \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/cr.minzdrav.gov.ru\/view-cr\/273_4. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 05.09.2024 [Khronicheskii pankreatit. Klinicheskie rekomendatsii. Available at: https:\/\/cr.minzdrav.gov.ru\/view-cr\/273_4. Accessed: 05.09.2024 (in Russian)]."},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s3196"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12674"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-020-00326-z"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/656027\/193083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/656027\/193083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:17:19Z","timestamp":1747225039000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/656027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,3,26]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2025.02.203192","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}