{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:05:25Z","timestamp":1777946725418,"version":"3.51.4"},"reference-count":16,"publisher":"Consilium Medicum","issue":"4","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. Development of a \u201cRisk Score Scale\u201d (RSS) to assess the risk of Major Adverse Cardiovascular Events (MACE) based on computed tomographic angiography (CT\u0410) of the coronary arteries in patients with acute coronary syndrome.\r\nMaterials and methods. The study included 249 p\u0430tients with acute coronary syndrome (77.5% of men, age 58.2\u00b110.7 years). Myocardial infarction occurred in 73.5% of patients, unstable angina \u2013 in 26.5%. After percutaneous coronary intervention CTA was performed by 320 \u2013 row CT scanner. 30 CT\u0410 characteristics were determined.\r\nResults. During 39.1 [18.0; 57.4] months of follow-up, 28.5% patients had combined primary endpoint events (PEE) including nonfatal myocardial infarction, unstable angina, cardiac death, unplanned percutaneous coronary intervention, ischemic stroke. RSS was developed by ROC analysis of the significant CT predictors of PEE, which were determined using a univariate Cox model. The uncensored period was 305 days \u2013 26 PEE. Using the Yuden method, cut-off values, AUC values, and other indicators were calculated for predictors. RSS included the following 8 most optimal predictors with their cut-off values and score values: \u201cnumber of coronary arteries with plaques\u201d 1.5 \u2013 1.0 point; \u201cmaximum plaque length\u201d 14.5 mm \u2013 1.16 points; \u201ctotal length of plaques\u201d 22.5 mm \u2013 1.17; \u201cmaximal coronary stenosis\u201d 77.5% \u2013 1.23; \u201cnumber of plaques with \u226550% stenosis\u201d 3,5 \u2013 1.1; \u201cminimum plaque density\u201d 29.1 HU \u2013 1.33; \u201cnumber of plaques with spotty calcifications\u201d 1.5 \u2013 1.23; \u201cnumber of low attenuation plaque 30 HU\u201d 0.5 \u2013 1.00. For the resulting RSS calculated threshold value was 3 points. A score of 3 points indicates a high risk of MACE: odds ratio 7.2, 95% CI 2.6\u201319.7 (p0.0001).\r\nConclusion. The use of RSS is a new and practically significant technique that makes it possible to improve the risk stratification of adverse outcomes.<\/jats:p>","DOI":"10.26442\/00403660.2026.04.203573","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:12:58Z","timestamp":1777752778000},"page":"202-208","source":"Crossref","is-referenced-by-count":0,"title":["A \"risk score scale\" based on computed tomography angiography of the coronary arteries to assess the risk of cardiovascular events in the first year after acute coronary syndrome"],"prefix":"10.26442","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-712X","authenticated-orcid":false,"given":"Irina N.","family":"Merkulova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-4315","authenticated-orcid":false,"given":"Elena B.","family":"Yarovaya","sequence":"additional","affiliation":[{"name":"Lomonosov Moscow State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-6623","authenticated-orcid":false,"given":"Tatiana S.","family":"Sukhinina","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-3911","authenticated-orcid":false,"given":"Svetlana A.","family":"Gaman","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-3714","authenticated-orcid":false,"given":"Tatiana N.","family":"Veselova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-5204","authenticated-orcid":false,"given":"Merab A.","family":"Shariya","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"},{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-911X","authenticated-orcid":false,"given":"Roman V.","family":"Ievlev","sequence":"additional","affiliation":[{"name":"National Research Center for Therapy and Preventive Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-1063","authenticated-orcid":false,"given":"Sergey K.","family":"Ternovoy","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"},{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5290-0065","authenticated-orcid":false,"given":"Dmitry V.","family":"Pevzner","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2022.10.n2238"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-048356"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.2741"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.09.013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.065"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2024.05.232"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2024.12.n2690"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2025.1.n2693"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.08.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.078"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev325"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(22)00022-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044720"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.052"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.066"}],"container-title":["Terapevticheskii 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