{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:05:26Z","timestamp":1777946726341,"version":"3.51.4"},"reference-count":20,"publisher":"Consilium Medicum","issue":"4","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To assess the circulating levels of IL-1 and its activity regulators, IL-1Ra and IL-1R2, in patients with acute decompensated heart failure (ADHF) depending on body mass index (BMI).\r\nMaterials and methods. The study included 159 patients hospitalized for ADHF. Depending on the BMI, the patients were assigned to 5 groups. The first group included 30 patients with healthy weight (BMI25 kg\/m2), the second \u2013 50 overweight patients (25\u2264BMI30 kg\/m2), the third \u2013 38 patients with class I obesity (30\u2264BMI35 kg\/m2), the fourth \u2013 28 patients with class II obesity (35\u2264BMI40 kg\/m2), the fifth group \u2013 13 patients with class III obesity (BMI\u226540 kg\/m2).\r\nResults. With increasing BMI, IL-1 levels increased, while IL-1R2 levels, on the contrary, decreased, but no statistically significant differences were found. IL-1Ra concentrations changed ambiguously and had U-shaped dependence. IL-1Ra levels were lower in overweight patients than in normal weight and obese groups. At the same time, the increase in obesity was accompanied by higher IL-1Ra levels. The highest IL-1Ra value was observed at a BMI\u226540 kg\/m2.\r\nConclusion. In ADHF an increase in obesity is accompanied by an increase in the inhibition of IL-1 activity, which may be one of the mechanisms by which adipose tissue exerts a protective effect.<\/jats:p>","DOI":"10.26442\/00403660.2026.04.203576","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:12:58Z","timestamp":1777752778000},"page":"226-230","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-1 activity regulators in acute decompensated heart failure: dependence on obesity degree"],"prefix":"10.26442","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-7085","authenticated-orcid":false,"given":"Alexandra A.","family":"Korotaeva","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-5736","authenticated-orcid":false,"given":"Elena V.","family":"Samoilova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"},{"name":"Pirogov Russian National Research Medical University (Pirogov University)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-4851","authenticated-orcid":false,"given":"Oleg S.","family":"Medvedev","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"},{"name":"Lomonosov Moscow State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4263-5936","authenticated-orcid":false,"given":"Daria A.","family":"Drugova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-7417","authenticated-orcid":false,"given":"Svetlana N.","family":"Nasonova","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-2661","authenticated-orcid":false,"given":"Igor V.","family":"Zhirov","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-6129","authenticated-orcid":false,"given":"Sergey N.","family":"Tereshchenko","sequence":"additional","affiliation":[{"name":"Chazov National Medical Research Center of Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2022.09.201837"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.09.007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001742"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.35336\/VA-2023-2-05"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00379.2020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-018-1684-z"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107765"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105885"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.04.006"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Borth W, Urbanski A, Prohaska R, et al. Binding of recombinant interleukin-1 beta to the third complement component and alpha 2-macroglobulin after activation of serum by immune complexes. Blood. 1990;75(12):2388-95. PMID: 1693530","DOI":"10.1182\/blood.V75.12.2388.2388"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Arend WP, Malyak M, Smith MF Jr, et al. Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J Immunol. 1994;153(10): 4766-74. PMID: 7963543","DOI":"10.4049\/jimmunol.153.10.4766"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.5.1104"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Fischer E, Van Zee KJ, Marano MA, et al. Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease. Blood. 1992;79(9):2196-200. PMID: 1533321","DOI":"10.1182\/blood.V79.9.2196.2196"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807865"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809568"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.07.044"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0928"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0004563216629997"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S168946"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/691513\/223317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/691513\/223317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:13:06Z","timestamp":1777752786000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/691513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,2]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,5,2]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2026.04.203576","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,2]]}}}