{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:46:39Z","timestamp":1787064399301,"version":"build-2736575974"},"reference-count":20,"publisher":"Consilium Medicum","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To evaluate the efficacy, safety and impact on gastrointestinal symptoms of Helicobacter pylori eradication therapy with a ready-to-use set of tablets and capsules [omeprazole 20 mg \u00d7 2, clarithromycin 500 mg \u00d7 2, amoxicillin 500 mg \u00d7 4] (Pylobact\u00ae AM) in duodenal ulcer patients within the framework of an observational program.\r\nMaterials and methods. 912 H. pylori-positive patients were included (404 men and 508 women, average age \u2013 43.8 years (43.82\u00b111.39; 18\u201364 years). Symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire; patients assessed treatment satisfaction, and physicians assessed treatment efficacy and tolerability using a five-point Likert scale. The efficacy of H. pylori eradication was assessed using the results of the 13C-urea breath test, H. pylori antigen stool test, or a rapid urea test with biopsies of the gastric body and antrum obtained during upper endoscopy. A total of 870 patients completed the observational program: 538 patients in the standard triple therapy group (PAM group) and 332 patients in the group enhanced with a bismuth preparation, rebamipide, and\/or a probiotic (PAMplus group). A subgroup of patients received triple therapy with bismuth and the synbiotic complex of Floriose with probiotic strains Lactobacillus acidophilus La-14, Lactobacillus rhamnosus Lr-32, Bifidobacterium lactis Bl-04, inulin and B vitamins.\r\nResults. H. pylori eradication rates in the PAM, PAMplus, and PAM+Bi+F (ITT) groups were 90.6, 97.03, and 96.82%, respectively. Treatment significantly reduced GSRS abdominal pain scores. Physicians rated the treatment efficacy and tolerability as \"very good\" or \"good\" at the end of the program in 93.3% of patients. Patients rated 93.68% as completely or mostly satisfied with the treatment.\r\nConclusion. The effectiveness of H. pylori eradication with a ready-to-use set of capsules and tablets for standard triple therapy is ensured by high patient compliance. The combination of standard triple therapy with bismuth, probiotics, and\/or rebamipide increases treatment efficacy.<\/jats:p>","DOI":"10.26442\/00403660.2026.08.203756","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:57:05Z","timestamp":1787061425000},"page":"451-457","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of &lt;i&gt;H. pylori&lt;\/i&gt; eradication therapy in real-world clinical practice: results of the \u00abPAMIR\u00bb observational program"],"prefix":"10.26442","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3954-9060","authenticated-orcid":false,"given":"Nikolay Yu.","family":"Alexeev","sequence":"additional","affiliation":[{"name":"Burdenko Voronezh State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4697-0624","authenticated-orcid":false,"given":"Tatyana O.","family":"Astaf\u2019eva","sequence":"additional","affiliation":[{"name":"Seredavin Samara Regional Clinical Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9867-5358","authenticated-orcid":false,"given":"Vanda V.","family":"Vishnevskaya","sequence":"additional","affiliation":[{"name":"City Clinical Hospital, Klin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9097-1713","authenticated-orcid":false,"given":"Natalia D.","family":"Donchenko","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2889-2588","authenticated-orcid":false,"given":"Valeria V.","family":"Zhuravleva","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3115-1749","authenticated-orcid":false,"given":"Polina A.","family":"Kruglova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6154-8163","authenticated-orcid":false,"given":"Anastasia A.","family":"Kurbatova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4942-4827","authenticated-orcid":false,"given":"Victoria M.","family":"Pakhomova","sequence":"additional","affiliation":[{"name":"Rostov State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-2729","authenticated-orcid":false,"given":"Liyudmila G.","family":"Ugay","sequence":"additional","affiliation":[{"name":"Pacific State Medical University"},{"name":"Far-East State Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5081-9098","authenticated-orcid":false,"given":"Irina A.","family":"Filipenkova","sequence":"additional","affiliation":[{"name":"City Polyclinic No. 8, Tyumen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6302-6341","authenticated-orcid":false,"given":"Irina R.","family":"Shigapova","sequence":"additional","affiliation":[{"name":"DarMedical LLC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-8725","authenticated-orcid":false,"given":"Tatiana 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