{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T13:52:23Z","timestamp":1648993943996},"reference-count":7,"publisher":"LLC Obyedinennaya Redaktsiya","issue":"11","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Today, there is no complete clarity about the pathogenetic mechanisms of the hepatic decompensation in patients with HCV-cirrhosis during the course of direct-acting antiviral (DAAs) therapy. The current article describes several clinical observations of decompensation (with the development of liver failure and portal hypertension) in cirrhotic patients during the course of DAAs-therapy of hepatitis C. The authors present contemporary views and their own assumptions about the possible mechanisms of the hepatic decompensation associated with DAAs-therapy in patients with liver cirrhosis.<\/jats:p>","DOI":"10.26442\/terarkh201890114-73","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T17:53:56Z","timestamp":1593453236000},"page":"67-73","source":"Crossref","is-referenced-by-count":0,"title":["Hepatic decompensation associated with an interferon-free antiviral therapy in patients with HCV-cirrhosis"],"prefix":"10.26442","volume":"90","author":[{"given":"S N","family":"Batskikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E V","family":"Vinnitskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu G","family":"Sandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T Yu","family":"Khaimenova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3422-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-10-200711200-00003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.051"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27950"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.08.016"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001606"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/32898\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/32898\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T17:54:08Z","timestamp":1593453248000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/32898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,15]]}},"URL":"https:\/\/doi.org\/10.26442\/terarkh201890114-73","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,15]]}}}