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Here, single-cell measurements of signal transduction intermediates in the mechanistic target of rapamycin complex 1 (mTORC1) pathway reveal that ventral NSPCs have higher levels of signaling than dorsal NSPCs<jats:italic>.<\/jats:italic>These features are linked with differences in mTORC1-driven disease severity: introduction of a pathognomonic<jats:italic>Tsc2<\/jats:italic>mutation only results in formation of tumor-like masses from the ventral V-SVZ. We propose a direct link between location-dependent intrinsic growth properties imbued by mTORC1 and predisposition to tumor development.<\/jats:p>","DOI":"10.26508\/lsa.201800218","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T21:15:28Z","timestamp":1553548528000},"page":"e201800218","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis"],"prefix":"10.26508","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-883X","authenticated-orcid":true,"given":"Gabrielle V","family":"Rushing","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asa 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