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Alliance"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications, which can affect their activity, localization, and stability. The most prevalent internal modification in mRNA is the methylation of adenosine at the N<jats:sup>6<\/jats:sup>-position (m<jats:sup>6<\/jats:sup>A). This returns mRNA to a role as a central hub of information within the cell, serving as an information carrier, modifier, and attenuator for many biological processes. Still, the precise role of internal mRNA modifications such as m<jats:sup>6<\/jats:sup>A in human and murine-dilated cardiac tissue remains unknown. Transcriptome-wide mapping of m<jats:sup>6<\/jats:sup>A in mRNA allowed us to catalog m<jats:sup>6<\/jats:sup>A targets in human and murine hearts. Increased m<jats:sup>6<\/jats:sup>A methylation was found in human cardiomyopathy. 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