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Disturbed epithelial polarity and cystogenesis upon DDR1 inhibition was caused by excess ROCK (rho-associated, coiled-coil-containing protein kinase)-driven actomyosin contractility, and pharmacological inhibition of ROCK was sufficient to correct these defects. Our data indicate that a DDR1-ROCK signaling axis is essential for the efficient establishment of epithelial polarity.<\/jats:p>","DOI":"10.26508\/lsa.201800276","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T22:09:27Z","timestamp":1550095767000},"page":"e201800276","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility"],"prefix":"10.26508","volume":"2","author":[{"given":"Pia Pernille","family":"S\u00f8gaard","sequence":"first","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Ito","sequence":"additional","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford, Oxford, 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