{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:09:04Z","timestamp":1790726944907,"version":"4.1.0"},"reference-count":72,"publisher":"Life Science Alliance, LLC","issue":"2","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CGC"},{"name":"NIH Office of Research Infrastructure Programs","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["#31003A_163447"],"award-info":[{"award-number":["#31003A_163447"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council","award":["741269"],"award-info":[{"award-number":["741269"]}]},{"name":"FMI"}],"content-domain":{"domain":["life-science-alliance.org"],"crossmark-restriction":true},"short-container-title":["Life Sci. Alliance"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    The juvenile-to-adult (J\/A) transition, or puberty, is a period of extensive changes of animal body morphology and function. The onset of puberty is genetically controlled, and the\n                    <jats:italic>let-7<\/jats:italic>\n                    miRNA temporally regulates J\/A transition events in nematodes and mammals. Here, we uncover the targets and downstream pathways through which\n                    <jats:italic>Caenorhabditis elegans let-7<\/jats:italic>\n                    controls male and female sexual organ morphogenesis and skin progenitor cell fates. We find that\n                    <jats:italic>let-7<\/jats:italic>\n                    directs all three processes by silencing a single target, the post-transcriptional regulator\n                    <jats:italic>lin-41<\/jats:italic>\n                    . In turn, the RNA-binding protein LIN41\/TRIM71 regulates these processes by silencing only four target mRNAs. Thus, by silencing LIN41,\n                    <jats:italic>let-7<\/jats:italic>\n                    activates LIN-29a and MAB-10 (an early growth response-type transcription factor and its NAB1\/2-orthologous cofactor, respectively) to terminate progenitor cell self-renewal and to promote vulval integrity. By contrast,\n                    <jats:italic>let-7<\/jats:italic>\n                    promotes development of the male sexual organ by up-regulating DMD-3 and MAB-3, two Doublesex\/MAB-3 domain\u2013containing transcription factors. Our results provide mechanistic insight into how a linear chain of post-transcriptional regulators diverges in the control of a small set of transcriptional regulators to achieve a coordinated J\/A transition.\n                  <\/jats:p>","DOI":"10.26508\/lsa.201900335","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T12:45:36Z","timestamp":1553517936000},"page":"e201900335","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["<i>let-7<\/i>\n                    coordinates the transition to adulthood through a single primary and four secondary targets"],"prefix":"10.26508","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-034X","authenticated-orcid":true,"given":"Florian","family":"Aeschimann","sequence":"first","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland"},{"name":"University of Basel, Basel, 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