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Alliance"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Chronic granulomatous disease (CGD) is a genetic disorder of the NADPH oxidase characterized by increased susceptibility to infections and hyperinflammation associated with defective autophagy and increased inflammasome activation. Herein, we demonstrate that thymosin \u03b24 (T\u03b24), a g-actin sequestering peptide with multiple and diverse intracellular and extracellular activities affecting inflammation, wound healing, fibrosis, and tissue regeneration, promoted in human and murine cells noncanonical autophagy, a form of autophagy associated with phagocytosis and limited inflammation via the death-associated protein kinase 1. We further show that the hypoxia inducible factor-1 (HIF-1)\u03b1 was underexpressed in CGD but normalized by T\u03b24 to promote autophagy and up-regulate genes involved in mucosal barrier protection. Accordingly, inflammation and granuloma formation were impaired and survival increased in CGD mice with colitis or aspergillosis upon T\u03b24 treatment or HIF-1\u03b1 stabilization. Thus, the promotion of endogenous pathways of inflammation resolution through HIF-1\u03b1 stabilization is druggable in CGD by T\u03b24.<\/jats:p>","DOI":"10.26508\/lsa.201900432","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T18:25:12Z","timestamp":1573583112000},"page":"e201900432","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Thymosin \u03b24 promotes autophagy and repair via HIF-1\u03b1 stabilization in chronic granulomatous disease"],"prefix":"10.26508","volume":"2","author":[{"given":"Giorgia","family":"Renga","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilis","family":"Oikonomou","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Perugia, Perugia, 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