{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:40:09Z","timestamp":1790887209664,"version":"4.1.0"},"reference-count":34,"publisher":"Life Science Alliance, LLC","issue":"5","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["SFI 15\/CDA\/3497 and SFI\/18\/TIDA\/6067"],"award-info":[{"award-number":["SFI 15\/CDA\/3497 and SFI\/18\/TIDA\/6067"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Irish Research Council Laureate award","award":["IRCLA\/2017\/295"],"award-info":[{"award-number":["IRCLA\/2017\/295"]}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health Research Board Ireland","award":["MRCG-2018-08"],"award-info":[{"award-number":["MRCG-2018-08"]}]}],"content-domain":{"domain":["life-science-alliance.org"],"crossmark-restriction":true},"short-container-title":["Life Sci. Alliance"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in axonal degeneration, but a role for SARM1 in photoreceptor cell degeneration has not been reported. SARM1 is known to mediate neuronal cell degeneration through depletion of essential metabolite NAD and induction of energy crisis. Here, we demonstrate that SARM1 is expressed in photoreceptors, and using retinal tissue explant, we confirm that activation of SARM1 causes destruction of NAD pools in the photoreceptor layer. Through generation of\n                    <jats:italic>rho<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>sarm1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    double knockout mice, we demonstrate that genetic deletion of SARM1 promotes both rod and cone photoreceptor cell survival in the rhodopsin knockout (\n                    <jats:italic>rho<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ) mouse model of photoreceptor degeneration. Finally, we demonstrate that SARM1 deficiency preserves cone visual function in the surviving photoreceptors when assayed by electroretinography. Overall, our data indicate that endogenous SARM1 has the capacity to consume NAD in photoreceptor cells and identifies a previously unappreciated role for SARM1-dependent cell death in photoreceptor cell degeneration.\n                  <\/jats:p>","DOI":"10.26508\/lsa.201900618","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T14:19:27Z","timestamp":1587392367000},"page":"e201900618","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration"],"prefix":"10.26508","volume":"3","author":[{"given":"Ema","family":"Ozaki","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland"},{"name":"Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-0895","authenticated-orcid":true,"given":"Luke","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland"},{"name":"Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno GB","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Manufacturing Engineering, Trinity College Dublin, Dublin, Ireland"},{"name":"Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kenna","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland"},{"name":"Research Foundation, Royal Victoria Eye and Ear Hospital Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Carty","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Humphries","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Humphries","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Campbell","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Manufacturing Engineering, Trinity College Dublin, Dublin, Ireland"},{"name":"Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland"},{"name":"Advance Materials and BioEngineering Research Centre at Trinity College Dublin and Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bowie","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-9380","authenticated-orcid":true,"given":"Sarah L","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland"},{"name":"Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland"},{"name":"National Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12380","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"2020042011192197000_3.5.e201900618.1","first-page":"546","article-title":"Specific binding of peanut lectin to a class of retinal photoreceptor cells. 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