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By combining our proteomic dataset with a literature-derived signaling network, we revealed that HFD modulates the \u03b2-catenin\u2013follistatin axis. These changes are accompanied by significant amelioration of the histological phenotype in dystrophic mice. Transplantation of purified FAPs from HFD-fed mice into the muscles of dystrophic recipients demonstrates that modulation of FAP metabolism can be functional to ameliorate the dystrophic phenotype. Our study supports metabolic reprogramming of muscle interstitial progenitor cells as a novel approach to alleviate some of the adverse outcomes of DMD.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202000660","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T14:05:12Z","timestamp":1580825112000},"page":"e202000646","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Metabolic reprogramming of fibro\/adipogenic progenitors facilitates muscle regeneration"],"prefix":"10.26508","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-7502","authenticated-orcid":true,"given":"Alessio","family":"Reggio","sequence":"first","affiliation":[{"name":"Department of Biology, University of Rome Tor Vergata, Rome, 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