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Alliance"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n                    Elevated amyloid precursor protein (APP) expression in the choroid plexus suggests an important role for extracellular APP metabolites such as sAPP\u03b1 in cerebrospinal fluid. Despite widespread\n                    <jats:italic>App<\/jats:italic>\n                    brain expression, we hypothesized that specifically targeting choroid plexus expression could alter animal physiology. Through various genetic and viral approaches in the adult mouse, we show that choroid plexus APP levels significantly impact proliferation in both subventricular zone and hippocampus dentate gyrus neurogenic niches. Given the role of A\u03b2 peptides in Alzheimer disease pathogenesis, we also tested whether favoring the production of A\u03b2 in choroid plexus could negatively affect niche functions. After AAV5-mediated long-term expression of human mutated\n                    <jats:italic>APP<\/jats:italic>\n                    specifically in the choroid plexus of adult wild-type mice, we observe reduced niche proliferation, reduced hippocampus APP expression, behavioral defects in reversal learning, and deficits in hippocampal long-term potentiation. Our findings highlight the unique role played by the choroid plexus in regulating brain function and suggest that targeting APP in choroid plexus may provide a means to improve hippocampus function and alleviate disease-related burdens.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202000703","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T12:35:20Z","timestamp":1632141320000},"page":"e202000703","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Choroid plexus APP regulates adult brain proliferation and animal behavior"],"prefix":"10.26508","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-4056","authenticated-orcid":true,"given":"Karen","family":"Arnaud","sequence":"first","affiliation":[{"name":"Centre for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Centre National de Recherche Scientifique (CNRS) UMR7241, INSERM U1050, 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