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However, we noted increased macrophage infiltration in the absence of c-Jun in hepatocytes, which when chemically depleted, reversed the phenotype. Consistently, <jats:italic>c-jun<\/jats:italic> deletion in KCs alone also led to reduced fibrosis and cytokine gene expression. By contrast, <jats:italic>c-jun<\/jats:italic> deletion in hepatocytes and KCs did not affect the resolution phase after fibrotic injury. These data together demonstrate a pro-fibrogenic role for c-Jun in hepatocytes and KCs that functionally interact to regulate liver fibrosis.<\/jats:p>","DOI":"10.26508\/lsa.202000803","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T20:40:21Z","timestamp":1611952821000},"page":"e202000803","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis"],"prefix":"10.26508","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-5351","authenticated-orcid":true,"given":"Min","family":"Xie","sequence":"first","affiliation":[{"name":"Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren 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