{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:40:36Z","timestamp":1790887236002,"version":"4.1.0"},"reference-count":85,"publisher":"Life Science Alliance, LLC","issue":"5","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education Tier 2","award":["MOE2016-T2-1-012"],"award-info":[{"award-number":["MOE2016-T2-1-012"]}]}],"content-domain":{"domain":["life-science-alliance.org"],"crossmark-restriction":true},"short-container-title":["Life Sci. Alliance"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for\n                    <jats:italic>Candida<\/jats:italic>\n                    persistence. Here, we describe a unique CD169\n                    <jats:sup>++<\/jats:sup>\n                    TRM subset that controls\n                    <jats:italic>Candida<\/jats:italic>\n                    growth and inflammation during acute systemic candidiasis. Their absence causes severe fungal-mediated renal pathology. CD169\n                    <jats:sup>++<\/jats:sup>\n                    TRMs, without being actively involved in direct fungal clearance, increase host resistance by promoting IFN-\u03b3 release and neutrophil ROS activity.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202000890","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T12:02:00Z","timestamp":1613736120000},"page":"e202000890","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Renal CD169\n                    <sup>++<\/sup>\n                    resident macrophages are crucial for protection against acute systemic candidiasis"],"prefix":"10.26508","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-3285","authenticated-orcid":true,"given":"Yi Juan","family":"Teo","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Liang","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Wai","family":"Mak","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Aphrilia","family":"Setiagani","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-7629","authenticated-orcid":true,"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajith Kumar","family":"Nair","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-6541","authenticated-orcid":true,"given":"Christiane","family":"Ruedl","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12380","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"2021021909000842000_4.5.e202000890.1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.4.1828-1836.1999"},{"key":"2021021909000842000_4.5.e202000890.2","doi-asserted-by":"publisher","DOI":"10.1086\/340635"},{"key":"2021021909000842000_4.5.e202000890.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30442-5"},{"key":"2021021909000842000_4.5.e202000890.4","doi-asserted-by":"publisher","DOI":"10.1086\/515645"},{"key":"2021021909000842000_4.5.e202000890.5","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.155"},{"key":"2021021909000842000_4.5.e202000890.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.002"},{"key":"2021021909000842000_4.5.e202000890.7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx445"},{"key":"2021021909000842000_4.5.e202000890.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-264903"},{"key":"2021021909000842000_4.5.e202000890.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.04.004"},{"key":"2021021909000842000_4.5.e202000890.10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp010"},{"key":"2021021909000842000_4.5.e202000890.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.011"},{"key":"2021021909000842000_4.5.e202000890.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0323-8"},{"key":"2021021909000842000_4.5.e202000890.13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121336"},{"key":"2021021909000842000_4.5.e202000890.14","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.4049\/jimmunol.161.7.3543","article-title":"IFN-gamma is required for IL-12 responsiveness in mice with Candida albicans infection","volume":"161","author":"Cenci","year":"1998","journal-title":"J Immunol"},{"key":"2021021909000842000_4.5.e202000890.15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00263"},{"key":"2021021909000842000_4.5.e202000890.16","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.1ma1219-275r"},{"key":"2021021909000842000_4.5.e202000890.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.03.013"},{"key":"2021021909000842000_4.5.e202000890.18","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq434"},{"key":"2021021909000842000_4.5.e202000890.19","doi-asserted-by":"publisher","DOI":"10.4161\/viru.26187"},{"key":"2021021909000842000_4.5.e202000890.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4988-5"},{"key":"2021021909000842000_4.5.e202000890.21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115050"},{"key":"2021021909000842000_4.5.e202000890.22","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.4049\/jimmunol.137.9.2980","article-title":"Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: Activation by interferon-gamma and tumor necrosis factor","volume":"137","author":"Djeu","year":"1986","journal-title":"J Immunol"},{"key":"2021021909000842000_4.5.e202000890.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.05.009"},{"key":"2021021909000842000_4.5.e202000890.24","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-142-12-3487"},{"key":"2021021909000842000_4.5.e202000890.25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00435"},{"key":"2021021909000842000_4.5.e202000890.26","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737728"},{"key":"2021021909000842000_4.5.e202000890.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.010"},{"key":"2021021909000842000_4.5.e202000890.28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00433.x"},{"key":"2021021909000842000_4.5.e202000890.29","doi-asserted-by":"publisher","DOI":"10.1038\/srep36055"},{"key":"2021021909000842000_4.5.e202000890.30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70143"},{"key":"2021021909000842000_4.5.e202000890.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15068-4"},{"key":"2021021909000842000_4.5.e202000890.32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.7.4135"},{"key":"2021021909000842000_4.5.e202000890.33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6779"},{"key":"2021021909000842000_4.5.e202000890.34","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1708-1717.1998"},{"key":"2021021909000842000_4.5.e202000890.35","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020195"},{"key":"2021021909000842000_4.5.e202000890.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.008"},{"key":"2021021909000842000_4.5.e202000890.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.103937"},{"key":"2021021909000842000_4.5.e202000890.38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"2021021909000842000_4.5.e202000890.39","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.2.436"},{"key":"2021021909000842000_4.5.e202000890.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0272-y"},{"key":"2021021909000842000_4.5.e202000890.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.059"},{"key":"2021021909000842000_4.5.e202000890.42","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx444"},{"key":"2021021909000842000_4.5.e202000890.43","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4049\/jimmunol.160.1.284","article-title":"The role of recombinant murine IL-12 and IFN-gamma in the pathogenesis of a murine systemic Candida albicans infection","volume":"160","author":"Lavigne","year":"1998","journal-title":"J Immunol"},{"key":"2021021909000842000_4.5.e202000890.44","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e5"},{"key":"2021021909000842000_4.5.e202000890.45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106114"},{"key":"2021021909000842000_4.5.e202000890.46","doi-asserted-by":"publisher","DOI":"10.1038\/ni1460"},{"key":"2021021909000842000_4.5.e202000890.47","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu029"},{"key":"2021021909000842000_4.5.e202000890.48","doi-asserted-by":"publisher","DOI":"10.1159\/000321157"},{"key":"2021021909000842000_4.5.e202000890.49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003079"},{"key":"2021021909000842000_4.5.e202000890.50","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71307"},{"key":"2021021909000842000_4.5.e202000890.51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16158-z"},{"key":"2021021909000842000_4.5.e202000890.52","doi-asserted-by":"publisher","DOI":"10.1038\/nri2729"},{"key":"2021021909000842000_4.5.e202000890.53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00576.x"},{"key":"2021021909000842000_4.5.e202000890.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006420"},{"key":"2021021909000842000_4.5.e202000890.55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01121.x"},{"key":"2021021909000842000_4.5.e202000890.56","doi-asserted-by":"publisher","DOI":"10.3109\/00365549309169671"},{"key":"2021021909000842000_4.5.e202000890.57","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"2021021909000842000_4.5.e202000890.58","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.6319-6329.2002"},{"key":"2021021909000842000_4.5.e202000890.59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116498"},{"key":"2021021909000842000_4.5.e202000890.60","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040052"},{"key":"2021021909000842000_4.5.e202000890.61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09599-8"},{"key":"2021021909000842000_4.5.e202000890.62","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.1403-1406.2006"},{"key":"2021021909000842000_4.5.e202000890.63","first-page":"161","article-title":"An overview of systemic Candida infections in peri-operative period and intensive care","volume":"2","author":"Nader-Djalal","year":"1998","journal-title":"Internet J Anesthesiology"},{"key":"2021021909000842000_4.5.e202000890.64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048475"},{"key":"2021021909000842000_4.5.e202000890.65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223919"},{"key":"2021021909000842000_4.5.e202000890.66","doi-asserted-by":"publisher","DOI":"10.1038\/nri3897"},{"key":"2021021909000842000_4.5.e202000890.67","doi-asserted-by":"publisher","DOI":"10.1086\/340511"},{"key":"2021021909000842000_4.5.e202000890.68","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"2021021909000842000_4.5.e202000890.69","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344359"},{"key":"2021021909000842000_4.5.e202000890.70","doi-asserted-by":"publisher","DOI":"10.3791\/50062"},{"key":"2021021909000842000_4.5.e202000890.71","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019040419"},{"key":"2021021909000842000_4.5.e202000890.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.014"},{"key":"2021021909000842000_4.5.e202000890.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.016"},{"key":"2021021909000842000_4.5.e202000890.74","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181049"},{"key":"2021021909000842000_4.5.e202000890.75","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.10.5756-5764.2003"},{"key":"2021021909000842000_4.5.e202000890.76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb03374.x"},{"key":"2021021909000842000_4.5.e202000890.77","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1929"},{"key":"2021021909000842000_4.5.e202000890.78","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.1700033"},{"key":"2021021909000842000_4.5.e202000890.79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402986"},{"key":"2021021909000842000_4.5.e202000890.80","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364130"},{"key":"2021021909000842000_4.5.e202000890.81","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit574"},{"key":"2021021909000842000_4.5.e202000890.82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004276"},{"key":"2021021909000842000_4.5.e202000890.83","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"2021021909000842000_4.5.e202000890.84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01798"},{"key":"2021021909000842000_4.5.e202000890.85","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S40160"}],"container-title":["Life Science Alliance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.26508\/lsa.202000890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:10:11Z","timestamp":1704877811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.life-science-alliance.org\/lookup\/doi\/10.26508\/lsa.202000890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":85,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,2,19]]},"published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.26508\/lsa.202000890"],"URL":"https:\/\/doi.org\/10.26508\/lsa.202000890","relation":{},"ISSN":["2575-1077"],"issn-type":[{"value":"2575-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]}}}