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Alliance"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n                    The mitochondrial unfolded protein response (mitoUPR) is an evolutionarily conserved pathway that responds to mitochondria insults through transcriptional changes, mediated by the transcription factor ATFS-1\/ATF-5, which acts to restore mitochondrial homeostasis. In this work, we characterized the role of ATFS-1 in responding to organismal stress. We found that activation of ATFS-1 is sufficient to cause up-regulation of genes involved in multiple stress response pathways including the DAF-16\u2013mediated stress response pathway, the cytosolic unfolded protein response, the endoplasmic reticulum unfolded protein response, the SKN-1\u2013mediated oxidative stress response pathway, the HIF-1-mediated hypoxia response pathway, the p38-mediated innate immune response pathway, and antioxidant genes. Constitutive activation of ATFS-1 increases resistance to multiple acute exogenous stressors, whereas disruption of\n                    <jats:italic>atfs-1<\/jats:italic>\n                    decreases stress resistance. Although ATFS-1\u2013dependent genes are up-regulated in multiple long-lived mutants, constitutive activation of ATFS-1 decreases lifespan in wild-type animals. Overall, our work demonstrates that ATFS-1 serves a vital role in organismal survival of acute stressors through its ability to activate multiple stress response pathways but that chronic ATFS-1 activation is detrimental for longevity.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202101182","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:36:45Z","timestamp":1632847005000},"page":"e202101182","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors"],"prefix":"10.26508","volume":"4","author":[{"given":"Sonja K","family":"Soo","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Canada"},{"name":"Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute 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