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Alliance"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>\n                    The intracellular bacterial pathogen\n                    <jats:italic>Legionella pneumophila<\/jats:italic>\n                    (\n                    <jats:italic>L.p.<\/jats:italic>\n                    ) secretes \u223c330 effector proteins into the host cell to sculpt an ER-derived replicative niche. We previously reported five\n                    <jats:italic>L.p.<\/jats:italic>\n                    effectors that inhibit IRE1, a key sensor of the homeostatic unfolded protein response (UPR) pathway. In this study, we discovered a subset of\n                    <jats:italic>L.p.<\/jats:italic>\n                    toxins that selectively activate the UPR sensor ATF6, resulting in its cleavage, nuclear translocation, and target gene transcription. In a deviation from the conventional model, this\n                    <jats:italic>L.p<\/jats:italic>\n                    .\u2013dependent activation of ATF6 does not require its transport to the Golgi or its cleavage by the S1P\/S2P proteases. We believe that our findings highlight the unique regulatory control that\n                    <jats:italic>L.p<\/jats:italic>\n                    . exerts upon the three UPR sensors and expand the repertoire of bacterial proteins that selectively perturb host homeostatic pathways.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202101247","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T15:53:17Z","timestamp":1633967597000},"page":"e202101247","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Non-canonical activation of the ER stress sensor ATF6 by\n                    <i>Legionella pneumophila<\/i>\n                    effectors"],"prefix":"10.26508","volume":"4","author":[{"given":"Nnejiuwa U","family":"Ibe","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 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