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Alliance"],"accepted":{"date-parts":[[2022,6,7]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    We evaluated the efficacy of ceftazidime or colistin in combination with polyclonal IgM-enriched immunoglobulin (IgM-IG), in an experimental pneumonia model (C57BL\/6J male mice) using two multidrug-resistant\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    strains, both ceftazidime-susceptible and one colistin-resistant. Pharmacodynamically optimised antimicrobials were administered for 72 h, and intravenous IgM-IG was given as a single dose. Bacterial tissues count and the mortality were analysed. Ceftazidime was more effective than colistin for both strains. In mice infected with the colistin-susceptible strain, ceftazidime reduced the bacterial concentration in the lungs and blood (\u22122.42 and \u22123.87 log\n                    <jats:sub>10<\/jats:sub>\n                    CFU\/ml) compared with colistin (\u22120.55 and \u22121.23 log\n                    <jats:sub>10<\/jats:sub>\n                    CFU\/ml, respectively) and with the controls. Colistin plus IgM-IG reduced the bacterial lung concentrations of both colistin-susceptible and resistant strains (\u22122.91 and \u22121.73 log\n                    <jats:sub>10<\/jats:sub>\n                    CFU\/g, respectively) and the bacteraemia rate of the colistin-resistant strain (\u221244%). These results suggest that IgM-IG might be useful as an adjuvant to colistin in the treatment of pneumonia caused by multidrug-resistant\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.26508\/lsa.202101349","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T13:50:19Z","timestamp":1655819419000},"page":"e202101349","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["IgM-enriched immunoglobulin improves colistin efficacy in a pneumonia model by\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.26508","volume":"5","author":[{"given":"Tania","family":"Cebrero-Cangueiro","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Herrera-Espejo","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/ University of Seville, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"\u00c1lvarez-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Virgen del Roc\u00edo University Hospital, Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital\/CSIC\/ University of Seville, Seville, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas, Madrid, 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