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Alliance"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Aberrant expression of dystrophin, utrophin, dysferlin, or calpain-3 was originally identified in muscular dystrophies (MDs). Increasing evidence now indicates that these proteins might act as tumor suppressors in myogenic and non-myogenic cancers. As DNA damage and somatic aneuploidy, hallmarks of cancer, are early pathological signs in MDs, we hypothesized that a common pathway might involve the centrosome. Here, we show that dystrophin, utrophin, dysferlin, and calpain-3 are functional constituents of the centrosome. In myoblasts, lack of any of these proteins caused excess centrosomes, centrosome misorientation, nuclear abnormalities, and impaired microtubule nucleation. In dystrophin double-mutants, these defects were significantly aggravated. Moreover, we demonstrate that also in non-myogenic cells, all four MD-related proteins localize to the centrosome, including the muscle-specific full-length dystrophin isoform. Therefore, MD-related proteins might share a convergent function at the centrosome in addition to their diverse, well-established muscle-specific functions. Thus, our findings support the notion that cancer-like centrosome-related defects underlie MDs and establish a novel concept linking MDs to cancer.<\/jats:p>","DOI":"10.26508\/lsa.202201367","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T19:20:13Z","timestamp":1657048813000},"page":"e202201367","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome"],"prefix":"10.26508","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-1160","authenticated-orcid":true,"given":"Lilli","family":"Winter","sequence":"first","affiliation":[{"name":"Neuromuscular Research Department, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, 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