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Alliance"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>\n                    Specific receptors for the neurohypophyseal hormones, arginine vasopressin (AVP) and oxytocin, are present in the male reproductive organs. However, their exact roles remain unknown. To elucidate the physiological functions of pituitary hormones in male reproduction, this study first focused on the distribution and function of one of the AVP receptors, V1a. In situ hybridization analysis revealed high expression of the\n                    <jats:italic>Avpr1a<\/jats:italic>\n                    in Leydig cells of the testes and narrow\/clear cells in the epididymis, with the expression pattern differing from that of the oxytocin receptor (OTR). Notably, persistent motility and highly proportional hyperactivation were observed in spermatozoa from V1a receptor\u2013deficient mice. In contrast, OTR blocking by antagonist atosiban decreased hyperactivation rate. Furthermore, AVP stimulation could alter the extracellular pH mediated by the V1a receptor. The results highlight the crucial role of neurohypophyseal hormones in male reproductive physiology, with potential contradicting roles of V1a and OTR in sperm maturation. Our findings suggest that V1a receptor antagonists are potential therapeutic drugs for male infertility.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202201488","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T04:26:40Z","timestamp":1674016000000},"page":"e202201488","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently"],"prefix":"10.26508","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-0344","authenticated-orcid":true,"given":"Hiroyoshi","family":"Tsuchiya","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/010hz0g26","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University","place":[", Shimotsuke, 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