{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:22:46Z","timestamp":1778862166441,"version":"3.51.4"},"reference-count":88,"publisher":"Life Science Alliance, LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["NS046769"],"award-info":[{"award-number":["NS046769"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP-159703"],"award-info":[{"award-number":["MOP-159703"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["life-science-alliance.org"],"crossmark-restriction":true},"short-container-title":["Life Sci. Alliance"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>Lupus autoimmunity frequently presents with neuropsychiatric manifestations, but underlying etiology remains poorly understood. Human brain cytoplasmic 200 RNA (BC200 RNA) is a translational regulator in neuronal synapto-dendritic domains. Here, we show that a BC200 guanosine-adenosine dendritic transport motif is recognized by autoantibodies from a subset of neuropsychiatric lupus patients. These autoantibodies impact BC200 functionality by quasi irreversibly displacing two RNA transport factors from the guanosine-adenosine transport motif. Such anti-BC autoantibodies, which can gain access to brains of neuropsychiatric lupus patients, give rise to clinical manifestations including seizures. To establish causality, naive mice with a permeabilized blood\u2013brain barrier were injected with anti-BC autoantibodies from lupus patients with seizures. Animals so injected developed seizure susceptibility with high mortality. Seizure activity was entirely precluded when animals were injected with lupus anti-BC autoantibodies together with BC200 decoy autoantigen. Seizures are a common clinical manifestation in neuropsychiatric lupus, and our work identifies anti-BC autoantibody activity as a mechanistic cause. The results demonstrate potential utility of BC200 decoys for autoantibody-specific therapeutic interventions in neuropsychiatric lupus.<\/jats:p>","DOI":"10.26508\/lsa.202201496","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T14:05:20Z","timestamp":1665669920000},"page":"e202201496","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus"],"prefix":"10.26508","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-8526","authenticated-orcid":true,"given":"Ilham A","family":"Muslimov","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Berardi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen M","family":"Ginzler","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G","family":"Hanly","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6995-3833","authenticated-orcid":true,"given":"Henri","family":"Tiedge","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"},{"name":"Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"},{"name":"Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12380","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"2023050408253235000_5.12.e202201496.1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"2023050408253235000_5.12.e202201496.2","doi-asserted-by":"publisher","DOI":"10.2307\/2685469"},{"key":"2023050408253235000_5.12.e202201496.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050501"},{"key":"2023050408253235000_5.12.e202201496.4","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.12.5673"},{"key":"2023050408253235000_5.12.e202201496.5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx860"},{"key":"2023050408253235000_5.12.e202201496.6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.711499"},{"key":"2023050408253235000_5.12.e202201496.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052433"},{"key":"2023050408253235000_5.12.e202201496.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00311-2"},{"key":"2023050408253235000_5.12.e202201496.9","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1862910"},{"key":"2023050408253235000_5.12.e202201496.10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO;2-8"},{"key":"2023050408253235000_5.12.e202201496.11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1777-05.2005"},{"key":"2023050408253235000_5.12.e202201496.12","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308094362"},{"key":"2023050408253235000_5.12.e202201496.13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.491001"},{"key":"2023050408253235000_5.12.e202201496.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2011.05.002"},{"key":"2023050408253235000_5.12.e202201496.15","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3379"},{"key":"2023050408253235000_5.12.e202201496.16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1257193"},{"key":"2023050408253235000_5.12.e202201496.17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116090"},{"key":"2023050408253235000_5.12.e202201496.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2624"},{"key":"2023050408253235000_5.12.e202201496.19","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000134"},{"key":"2023050408253235000_5.12.e202201496.20","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.278"},{"key":"2023050408253235000_5.12.e202201496.21","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0895"},{"key":"2023050408253235000_5.12.e202201496.22","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05885-11"},{"key":"2023050408253235000_5.12.e202201496.23","doi-asserted-by":"crossref","unstructured":"Eom T , Muslimov IA , Iacoangeli A , Tiedge H (2021) Dendritic targeting and regulatory RNA control of local neuronal translation. In The Oxford Handbook of Neuronal Protein Synthesis, Sossin W (ed), pp 105\u2013129. New York: Oxford University Press. Published online at oxfordhandbooks.com .","DOI":"10.1093\/oxfordhb\/9780190686307.013.8"},{"key":"2023050408253235000_5.12.e202201496.24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201401005"},{"key":"2023050408253235000_5.12.e202201496.25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.17.3197"},{"key":"2023050408253235000_5.12.e202201496.26","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq253"},{"key":"2023050408253235000_5.12.e202201496.27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.154476"},{"key":"2023050408253235000_5.12.e202201496.28","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5176604"},{"key":"2023050408253235000_5.12.e202201496.29","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa404"},{"key":"2023050408253235000_5.12.e202201496.30","unstructured":"Hanly JG (2019) Overview of Neuropsychiatric SLE: Current Status and Future Directions. Atlanta, GA: ACR\/ARP Annual Meeting."},{"key":"2023050408253235000_5.12.e202201496.31","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"2023050408253235000_5.12.e202201496.32","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2018-000717"},{"key":"2023050408253235000_5.12.e202201496.33","doi-asserted-by":"publisher","DOI":"10.1101\/lm.045427.117"},{"key":"2023050408253235000_5.12.e202201496.34","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh228"},{"key":"2023050408253235000_5.12.e202201496.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.11.001"},{"key":"2023050408253235000_5.12.e202201496.36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249749"},{"key":"2023050408253235000_5.12.e202201496.37","doi-asserted-by":"publisher","DOI":"10.1038\/35104069"},{"key":"2023050408253235000_5.12.e202201496.38","doi-asserted-by":"publisher","DOI":"10.1261\/rna.040899.113"},{"key":"2023050408253235000_5.12.e202201496.39","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00071"},{"key":"2023050408253235000_5.12.e202201496.40","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1082"},{"key":"2023050408253235000_5.12.e202201496.41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608397104"},{"key":"2023050408253235000_5.12.e202201496.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.011"},{"key":"2023050408253235000_5.12.e202201496.43","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020313"},{"key":"2023050408253235000_5.12.e202201496.44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf481"},{"key":"2023050408253235000_5.12.e202201496.45","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838201002515"},{"key":"2023050408253235000_5.12.e202201496.46","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba4991"},{"key":"2023050408253235000_5.12.e202201496.47","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01800-07"},{"key":"2023050408253235000_5.12.e202201496.48","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00003-3"},{"key":"2023050408253235000_5.12.e202201496.49","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.106"},{"key":"2023050408253235000_5.12.e202201496.50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01101"},{"key":"2023050408253235000_5.12.e202201496.51","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-006-9065-8"},{"key":"2023050408253235000_5.12.e202201496.52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00035"},{"key":"2023050408253235000_5.12.e202201496.53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11563"},{"key":"2023050408253235000_5.12.e202201496.54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9698"},{"key":"2023050408253235000_5.12.e202201496.55","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.7.6.2148-2154.1987"},{"key":"2023050408253235000_5.12.e202201496.56","doi-asserted-by":"publisher","DOI":"10.1021\/jp808357m"},{"key":"2023050408253235000_5.12.e202201496.57","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh693"},{"key":"2023050408253235000_5.12.e202201496.58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.48.34389"},{"key":"2023050408253235000_5.12.e202201496.59","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.7.1601"},{"key":"2023050408253235000_5.12.e202201496.60","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0091-18.2018"},{"key":"2023050408253235000_5.12.e202201496.61","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200607008"},{"key":"2023050408253235000_5.12.e202201496.62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1657-18.2019"},{"key":"2023050408253235000_5.12.e202201496.63","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010027"},{"key":"2023050408253235000_5.12.e202201496.64","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201310045"},{"key":"2023050408253235000_5.12.e202201496.65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb01499.x"},{"key":"2023050408253235000_5.12.e202201496.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.08.007"},{"key":"2023050408253235000_5.12.e202201496.67","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3888-10.2010"},{"key":"2023050408253235000_5.12.e202201496.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00543-w"},{"key":"2023050408253235000_5.12.e202201496.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.07.005"},{"key":"2023050408253235000_5.12.e202201496.70","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838201002485"},{"key":"2023050408253235000_5.12.e202201496.71","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-475-3_7"},{"key":"2023050408253235000_5.12.e202201496.72","doi-asserted-by":"publisher","DOI":"10.1038\/laban.481"},{"key":"2023050408253235000_5.12.e202201496.73","doi-asserted-by":"publisher","DOI":"10.1007\/PL00006426"},{"key":"2023050408253235000_5.12.e202201496.74","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.18.6435-6441.2003"},{"key":"2023050408253235000_5.12.e202201496.75","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3167"},{"key":"2023050408253235000_5.12.e202201496.76","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180239"},{"key":"2023050408253235000_5.12.e202201496.77","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474179"},{"key":"2023050408253235000_5.12.e202201496.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.12.003"},{"key":"2023050408253235000_5.12.e202201496.79","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-22-07171.1996"},{"key":"2023050408253235000_5.12.e202201496.80","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-06-02382.1993"},{"key":"2023050408253235000_5.12.e202201496.81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.6.2093"},{"key":"2023050408253235000_5.12.e202201496.82","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3537-09.2010"},{"key":"2023050408253235000_5.12.e202201496.83","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200506006"},{"key":"2023050408253235000_5.12.e202201496.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.08.010"},{"key":"2023050408253235000_5.12.e202201496.85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00087.x"},{"key":"2023050408253235000_5.12.e202201496.86","doi-asserted-by":"publisher","DOI":"10.1038\/laban0511-155"},{"key":"2023050408253235000_5.12.e202201496.87","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3893-08.2009"},{"key":"2023050408253235000_5.12.e202201496.88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015509"}],"container-title":["Life Science Alliance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.26508\/lsa.202201496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T19:06:02Z","timestamp":1728155162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.life-science-alliance.org\/lookup\/doi\/10.26508\/lsa.202201496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":88,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,10,13]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.26508\/lsa.202201496"],"URL":"https:\/\/doi.org\/10.26508\/lsa.202201496","relation":{},"ISSN":["2575-1077"],"issn-type":[{"value":"2575-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]}}}