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It is associated with increased long-term maternal cardiovascular disease risk. This study assesses the effect of the vasoconstrictor N(\u03c9)-nitro-L-arginine methyl ester (L-NAME) in modelling preeclampsia in mice, and its long-term effects on maternal cardiovascular health. In this study, we found that L-NAME administration mimicked key characteristics of preeclampsia, including elevated blood pressure, impaired fetal and placental growth, and increased circulating endothelin-1 (vasoconstrictor), soluble fms-like tyrosine kinase-1 (anti-angiogenic factor), and C-reactive protein (inflammatory marker). Post-delivery, mice that received L-NAME in pregnancy recovered, with no discernible changes in measured cardiovascular indices at 1-, 2-, and 4-wk post-delivery, compared with matched controls. At 10-wk post-delivery, arteries collected from the L-NAME mice constricted significantly more to phenylephrine than controls. In addition, these mice had increased kidney<jats:italic>Mmp9:Timp1<\/jats:italic>and heart<jats:italic>Tnf<\/jats:italic>mRNA expression, indicating increased inflammation. These findings suggest that though administration of L-NAME in mice certainly models key characteristics of preeclampsia during pregnancy, it does not appear to model the adverse increase in cardiovascular disease risk seen in individuals after preeclampsia.<\/jats:p>","DOI":"10.26508\/lsa.202201517","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T15:26:58Z","timestamp":1661441218000},"page":"e202201517","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health"],"prefix":"10.26508","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-0096","authenticated-orcid":true,"given":"Natasha","family":"de Alwis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Therapeutics Discovery and Vascular Function Group, The University of Melbourne and 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