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Alliance"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                    <jats:italic>Sry<\/jats:italic>\n                    on the Y chromosome is the master switch of sex determination in mammals. It has been well established that\n                    <jats:italic>Sry<\/jats:italic>\n                    encodes a transcription factor that is transiently expressed in somatic cells of the male gonad, leading to the formation of testes. In the testis of adult mice,\n                    <jats:italic>Sry<\/jats:italic>\n                    is expressed as a circular RNA (circRNA) transcript. However, the physiological function of\n                    <jats:italic>Sry<\/jats:italic>\n                    circRNA (circSRY) remains unknown since its discovery in 1993. Here we show that circSRY is mainly expressed in the spermatocytes, but not in mature sperm or somatic cells of the testis. Loss of circSRY led to germ cell apoptosis and the reduction of sperm count in the epididymis. The level of \u03b3H2AX was decreased, and failure of XY body formation was noted in circSRY KO germ cells. Further study demonstrated that circSRY directly bound to miR-138-5p in spermatocytes, and in vitro assay suggested that circSRY regulates H2AX mRNA through sponging miR-138-5p. Our study demonstrates that, besides determining sex,\n                    <jats:italic>Sry<\/jats:italic>\n                    also plays an important role in spermatogenesis as a circRNA.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202201617","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T13:05:13Z","timestamp":1669122313000},"page":"e202201617","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Loss of circSRY reduces \u03b3H2AX level in germ cells and impairs mouse spermatogenesis"],"prefix":"10.26508","volume":"6","author":[{"given":"Yanze","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-6705","authenticated-orcid":true,"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen, P.R. 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