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The results of this work, on the one hand, confirm the importance of the genetic background in the severity of the cognitive disorders in individuals with T2DM and, on the other hand, suggest, among the involved mechanisms, the inhibition of \u03b3-secretase activity.<\/jats:p>","DOI":"10.26508\/lsa.202201789","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T03:26:28Z","timestamp":1681874788000},"page":"e202201789","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Cognitive decline in diabetic mice predisposed to Alzheimer\u2019s disease is greater than in wild type"],"prefix":"10.26508","volume":"6","author":[{"given":"Marta","family":"Car\u00fas-Cadavieco","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v9e8t09","id-type":"ROR","asserted-by":"publisher"}],"name":"Molecular Neuropathology Unit, Physiological and Pathological Processes Program, Centro de 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