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Importantly, TNF\u03b1 neutralization during pregnancy enabled to ameliorate ASD-like phenotypes and restore the NF\u03baB activation level in the offspring exposed to PE. Furthermore, TNF\u03b1\/NF\u03baB signaling axis, but not L-NAME, caused deficits in neuroprogenitor cell proliferation and synaptic development. These experiments demonstrate that offspring exposed to PE phenocopies ASD signatures reported in humans and indicate therapeutic targeting of TNF\u03b1 decreases the likelihood of bearing children with ASD phenotypes from PE mothers.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202301957","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T12:00:23Z","timestamp":1686225623000},"page":"e202301957","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Preeclampsia promotes autism in offspring via maternal inflammation and fetal NF\u03baB signaling"],"prefix":"10.26508","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-6744","authenticated-orcid":false,"given":"Xueyuan","family":"Liu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04rhdtb47","id-type":"ROR","asserted-by":"publisher"}],"name":"Obstetrics and Gynecology Hospital of Fudan 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