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Alliance"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Glaucoma is a common neurodegenerative disorder characterized by retinal ganglion cell death, astrocyte reactivity in the optic nerve, and vision loss. Currently, lowering the intraocular pressure (IOP) is the first-line treatment, but adjuvant neuroprotective approaches would be welcome. Vitamin C possesses neuroprotective activities that are thought to be related to its properties as a co-factor of enzymes and its antioxidant effects. Here, we show that vitamin C promotes a neuroprotective phenotype and increases gene expression related to neurotropic factors, phagocytosis, and mitochondrial ATP production. This effect is dependent on the up-regulation of secreted phosphoprotein 1 (SPP1) in reactive astrocytes via the transcription factor E2F1. SPP1\n                    <jats:sup>+<\/jats:sup>\n                    astrocytes in turn promote retinal ganglion cell survival in a mouse model of glaucoma. In addition, oral administration of vitamin C lowers the IOP in mice. This study identifies an additional neuroprotective pathway for vitamin C and suggests a potential therapeutic role of vitamin C in neurodegenerative diseases such as glaucoma.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202301976","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T15:40:40Z","timestamp":1683646840000},"page":"e202301976","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin C protects retinal ganglion cells via SPP1 in glaucoma and after optic nerve damage"],"prefix":"10.26508","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-4893","authenticated-orcid":true,"given":"Song","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Harvard Medical School, Boston, MA, USA"},{"id":[{"id":"https:\/\/ror.org\/04g3dn724","id-type":"ROR","asserted-by":"publisher"}],"name":"Schepens Eye Research Institute, 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