{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:56:30Z","timestamp":1785426990352,"version":"3.56.0"},"reference-count":55,"publisher":"Life Science Alliance, LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010293"],"award-info":[{"award-number":["2023A1515010293"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["life-science-alliance.org"],"crossmark-restriction":true},"short-container-title":["Life Sci. Alliance"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Proper retinoic acid (RA) signaling is essential for normal craniofacial development. Both excessive RA and RA deficiency in early embryonic stage may lead to a variety of craniofacial malformations, for example, cleft palate, which have been investigated extensively. Dysregulated Wnt and Shh signaling were shown to underlie the pathogenesis of RA-induced craniofacial defects. In our present study, we showed a spatiotemporal-specific effect of RA signaling in regulating early development of facial prominences. Although inhibited Wnt activities was observed in E12.5\/E13.5 mouse palatal shelves, early exposure of excessive RA induced Wnt signaling and Wnt-related gene expression in E11.5\/E12.5 mouse embryonic frontonasal\/maxillary processes. A conserved regulatory network of\n                    <jats:italic>miR-484<\/jats:italic>\n                    -\n                    <jats:italic>Fzd5<\/jats:italic>\n                    was identified to play critical roles in RA-regulated craniofacial development using RNA-seq. In addition, subsequent osteogenic\/chondrogenic differentiation were differentially regulated in discrete mouse embryonic facial prominences in response to early RA induction, demonstrated using both in vitro and in vivo analyses.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202302013","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T13:50:20Z","timestamp":1691157020000},"page":"e202302013","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["RA-induced prominence-specific response resulted in distinctive regulation of Wnt and osteogenesis"],"prefix":"10.26508","volume":"6","author":[{"given":"Chao","family":"Song","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02xe5ns62","id-type":"ROR","asserted-by":"publisher"}],"name":"The Key Laboratory of Virology of Guangzhou, Jinan University","place":[", Guangzhou, 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