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Alliance"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in<jats:italic>Vdr<\/jats:italic>-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in<jats:italic>Vdr<\/jats:italic>-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as \u201csurviving epithelial strands.\u201d Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. 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