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Alliance"],"accepted":{"date-parts":[[2024,4,29]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    Celiac disease (CD) is an autoimmune enteropathy resulting from an interaction between diet, genome, and immunity. Although many patients respond to a gluten-free diet, in a substantive number of individuals, the intestinal injury persists. Thus, other factors might amplify the ongoing inflammation.\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is a commensal fungus that is well adapted to the intestinal life. However, specific conditions increase\n                    <jats:italic>Candida<\/jats:italic>\n                    pathogenicity. The hypothesis that\n                    <jats:italic>Candida<\/jats:italic>\n                    may be a trigger in CD has been proposed after the observation of similarity between a fungal wall component and two CD-related gliadin T-cell epitopes. However, despite being implicated in intestinal disorders,\n                    <jats:italic>Candida<\/jats:italic>\n                    may also protect against immune pathologies highlighting a more intriguing role in the gut. Herein, we postulated that a state of chronic inflammation associated with microbial dysbiosis and leaky gut are favorable conditions that promote\n                    <jats:italic>C. albicans<\/jats:italic>\n                    pathogenicity eventually contributing to CD pathology via a mast cells (MC)-IL-9 axis. However, the restoration of immune and microbial homeostasis promotes a beneficial\n                    <jats:italic>C. albicans<\/jats:italic>\n                    \u2013MC cross-talk favoring the attenuation of CD pathology to alleviate CD pathology and symptoms.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202302441","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T12:30:36Z","timestamp":1715171436000},"page":"e202302441","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["The immune and microbial homeostasis determines the\n                    <i>Candida<\/i>\n                    \u2013mast cells cross-talk in celiac 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