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Alliance"],"accepted":{"date-parts":[[2024,9,24]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    Preeclampsia (PE) is a hypertensive disorder of pregnancy and a major cause of maternal\/perinatal adverse health outcomes with no effective therapeutic strategies. Our group previously identified distinct subclasses of PE, one of which exhibits heightened placental inflammation (inflammation-driven PE). In non-pregnant populations, chronic inflammation is associated with decreased levels of cellular NAD\n                    <jats:sup>+<\/jats:sup>\n                    , a vitamin B3 derivative involved in energy metabolism and mitochondrial function. Interestingly, specifically in placentas from women with inflammation-driven PE, we observed the increased activity of NAD\n                    <jats:sup>+<\/jats:sup>\n                    -consuming enzymes, decreased NAD\n                    <jats:sup>+<\/jats:sup>\n                    content, decreased expression of mitochondrial proteins, and increased oxidative damage. HTR8 human trophoblasts likewise demonstrated increased NAD\n                    <jats:sup>+<\/jats:sup>\n                    -dependent ADP-ribosyltransferase (ART) activity, coupled with decreased mitochondrial respiration rates and invasive function under inflammatory conditions. Such adverse effects were attenuated by boosting cellular NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels with nicotinamide riboside (NR). Finally, in an LPS-induced rat model of inflammation-driven PE, NR administration (200 mg\/kg\/day) from gestational days 1\u201319 prevented maternal hypertension and fetal\/placental growth restriction, improved placental mitochondrial function, and reduced inflammation and oxidative stress. This study demonstrates the critical role of NAD\n                    <jats:sup>+<\/jats:sup>\n                    in maintaining placental function and identifies NAD\n                    <jats:sup>+<\/jats:sup>\n                    boosting as a promising preventative strategy for PE.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202302505","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:50:15Z","timestamp":1728575415000},"page":"e202302505","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["NAD\n                    <sup>+<\/sup>\n                    depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia"],"prefix":"10.26508","volume":"7","author":[{"given":"Fahmida","family":"Jahan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03c4mmv16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of 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