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Severe patients showed enrichment in retained intron and nonsense-mediated decay transcript biotypes, suggesting altered splicing efficiency. Furthermore, an up-regulated programmed cell death, a haemolytic response, and an impaired interferon and antiviral response at the transcript level were observed. We also identified the potential involvement of the\n                    <jats:italic>RBM39<\/jats:italic>\n                    gene among others in the innate immune response during dengue viral pathogenesis, warranting further investigation. These findings provide valuable insights into potential therapeutic targets, underscoring the importance of exploring transcriptomic landscapes between different disease sub-phenotypes in infectious diseases.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202402683","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T15:35:18Z","timestamp":1717428918000},"page":"e202402683","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing"],"prefix":"10.26508","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-4322","authenticated-orcid":true,"given":"Priyanka","family":"Mehta","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinky Shiu Chen","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sristi","family":"Sinha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakant","family":"Mohite","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smriti","family":"Arora","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Chattopadhyay","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Budhiraja","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00e7r7m66","id-type":"ROR","asserted-by":"publisher"}],"name":"Max Super Speciality Hospital","place":["(A Unit of Devki Devi Foundation), Max Healthcare, Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bansidhar","family":"Tarai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00e7r7m66","id-type":"ROR","asserted-by":"publisher"}],"name":"Max Super Speciality Hospital","place":["(A Unit of Devki Devi Foundation), Max Healthcare, Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-8327","authenticated-orcid":true,"given":"Rajesh","family":"Pandey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ef28661","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology","place":["(CSIR-IGIB), Delhi, India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12380","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"2024080108000965000_7.8.e202402683.1","unstructured":"Dengue and Severe Dengue (2024). 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