{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:24Z","timestamp":1787317764318,"version":"build-2736575974"},"reference-count":105,"publisher":"Life Science Alliance, LLC","issue":"11","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012529","name":"Insamlingsstiftelsen Diabetes Wellness Network Sverige","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012529","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Research Programmes in Diabetes"},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KX1012"],"award-info":[{"award-number":["01KX1012"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsches Zentrum fur Diabetesforschung"}],"content-domain":{"domain":["life-science-alliance.org"],"crossmark-restriction":true},"short-container-title":["Life Sci. Alliance"],"accepted":{"date-parts":[[2024,8,8]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Regeneration of insulin-producing \u03b2-cells is an alternative avenue to manage diabetes, and it is crucial to unravel this process in vivo during physiological responses to the lack of \u03b2-cells. Here, we aimed to characterize how hepatocytes can contribute to \u03b2-cell regeneration, either directly or indirectly via secreted proteins or metabolites, in a zebrafish model of \u03b2-cell loss. Using lineage tracing, we show that hepatocytes do not directly convert into \u03b2-cells even under extreme \u03b2-cell ablation conditions. A transcriptomic analysis of isolated hepatocytes after \u03b2-cell ablation displayed altered lipid- and glucose-related processes. Based on the transcriptomics, we performed a genetic screen that uncovers a potential role of the molybdenum cofactor (Moco) biosynthetic pathway in \u03b2-cell regeneration and glucose metabolism in zebrafish. Consistently, molybdenum cofactor synthesis 2 (\n                    <jats:italic>Mocs2<\/jats:italic>\n                    ) haploinsufficiency in mice indicated dysregulated glucose metabolism and liver function. Together, our study sheds light on the liver\u2013pancreas crosstalk and suggests that the molybdenum cofactor biosynthesis pathway should be further studied in relation to glucose metabolism and diabetes.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202402771","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T12:55:17Z","timestamp":1724072117000},"page":"e202402771","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Examining the liver\u2013pancreas crosstalk reveals a role for the molybdenum cofactor in \u03b2-cell regeneration"],"prefix":"10.26508","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-5760","authenticated-orcid":true,"given":"Christos","family":"Karampelias","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell and Molecular Biology, Karolinska Institutet","place":[", Stockholm, Sweden"]},{"name":"Institute of Diabetes and Regeneration Research, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8047-3515","authenticated-orcid":true,"given":"Bianca","family":"B\u0103loiu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell and Molecular Biology, Karolinska Institutet","place":[", Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Rathkolb","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum M\u00fcnchen","place":[", Neuherberg, Germany"]},{"name":"Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-3399","authenticated-orcid":true,"given":"Patricia","family":"da Silva-Buttkus","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum M\u00fcnchen","place":[", Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-6721","authenticated-orcid":true,"given":"Etty","family":"Bachar-Wikstr\u00f6m","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell and Molecular Biology, Karolinska Institutet","place":[", Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Marschall","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum M\u00fcnchen","place":[", Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Fuchs","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum M\u00fcnchen","place":[", Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gailus-Durner","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum M\u00fcnchen","place":[", Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhe","family":"Chu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell and Molecular Biology, Karolinska Institutet","place":[", Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00cfam450","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum M\u00fcnchen","place":[", Neuherberg, Germany"]},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Germany"},{"name":"Chair of Experimental Genetics, TUM School of Life Sciences, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6715-781X","authenticated-orcid":true,"given":"Olov","family":"Andersson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell and Molecular Biology, Karolinska Institutet","place":[", Stockholm, Sweden"]},{"name":"Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12380","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2024110107452488000_7.11.e202402771.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.002"},{"key":"2024110107452488000_7.11.e202402771.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03873-9"},{"key":"2024110107452488000_7.11.e202402771.3","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"2024110107452488000_7.11.e202402771.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.018"},{"key":"2024110107452488000_7.11.e202402771.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.06.018"},{"key":"2024110107452488000_7.11.e202402771.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0132-z"},{"key":"2024110107452488000_7.11.e202402771.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201701109"},{"key":"2024110107452488000_7.11.e202402771.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"2024110107452488000_7.11.e202402771.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101477"},{"key":"2024110107452488000_7.11.e202402771.10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303127200"},{"key":"2024110107452488000_7.11.e202402771.11","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2141"},{"key":"2024110107452488000_7.11.e202402771.12","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyac016"},{"key":"2024110107452488000_7.11.e202402771.13","doi-asserted-by":"publisher","DOI":"10.1101\/2024.06.20.599862"},{"key":"2024110107452488000_7.11.e202402771.14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73178"},{"key":"2024110107452488000_7.11.e202402771.15","doi-asserted-by":"publisher","DOI":"10.1038\/nature13633"},{"key":"2024110107452488000_7.11.e202402771.16","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03552-w"},{"key":"2024110107452488000_7.11.e202402771.17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001068"},{"key":"2024110107452488000_7.11.e202402771.18","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05822-2"},{"key":"2024110107452488000_7.11.e202402771.19","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21100"},{"key":"2024110107452488000_7.11.e202402771.20","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0153"},{"key":"2024110107452488000_7.11.e202402771.21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002754"},{"key":"2024110107452488000_7.11.e202402771.22","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201704044"},{"key":"2024110107452488000_7.11.e202402771.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.01.007"},{"key":"2024110107452488000_7.11.e202402771.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.001"},{"key":"2024110107452488000_7.11.e202402771.25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006031"},{"key":"2024110107452488000_7.11.e202402771.26","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0130"},{"key":"2024110107452488000_7.11.e202402771.27","doi-asserted-by":"publisher","DOI":"10.1038\/75050"},{"key":"2024110107452488000_7.11.e202402771.28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82498"},{"key":"2024110107452488000_7.11.e202402771.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2010.08.006"},{"key":"2024110107452488000_7.11.e202402771.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.09.048"},{"key":"2024110107452488000_7.11.e202402771.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0942-8"},{"key":"2024110107452488000_7.11.e202402771.32","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-015-0179-4"},{"key":"2024110107452488000_7.11.e202402771.33","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13228"},{"key":"2024110107452488000_7.11.e202402771.34","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac193"},{"key":"2024110107452488000_7.11.e202402771.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.08.003"},{"key":"2024110107452488000_7.11.e202402771.36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac972"},{"key":"2024110107452488000_7.11.e202402771.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"2024110107452488000_7.11.e202402771.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00157-1"},{"key":"2024110107452488000_7.11.e202402771.39","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00876-x"},{"key":"2024110107452488000_7.11.e202402771.40","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00516-2"},{"key":"2024110107452488000_7.11.e202402771.41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23673-0"},{"key":"2024110107452488000_7.11.e202402771.42","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01047-x"},{"key":"2024110107452488000_7.11.e202402771.43","doi-asserted-by":"publisher","DOI":"10.1242\/dev.056499"},{"key":"2024110107452488000_7.11.e202402771.44","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0155"},{"key":"2024110107452488000_7.11.e202402771.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.010"},{"key":"2024110107452488000_7.11.e202402771.46","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124544"},{"key":"2024110107452488000_7.11.e202402771.47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44589-x"},{"key":"2024110107452488000_7.11.e202402771.48","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1587"},{"key":"2024110107452488000_7.11.e202402771.49","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"2024110107452488000_7.11.e202402771.50","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592903"},{"key":"2024110107452488000_7.11.e202402771.51","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1841"},{"key":"2024110107452488000_7.11.e202402771.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.03.003"},{"key":"2024110107452488000_7.11.e202402771.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.04.002"},{"key":"2024110107452488000_7.11.e202402771.54","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88813.2"},{"key":"2024110107452488000_7.11.e202402771.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118883"},{"key":"2024110107452488000_7.11.e202402771.56","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1198-2"},{"key":"2024110107452488000_7.11.e202402771.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.06.003"},{"key":"2024110107452488000_7.11.e202402771.58","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1019"},{"key":"2024110107452488000_7.11.e202402771.59","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf5142"},{"key":"2024110107452488000_7.11.e202402771.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2024.05.002"},{"key":"2024110107452488000_7.11.e202402771.61","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00010-1"},{"key":"2024110107452488000_7.11.e202402771.62","doi-asserted-by":"publisher","DOI":"10.1242\/dev.059345"},{"key":"2024110107452488000_7.11.e202402771.63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206131109"},{"key":"2024110107452488000_7.11.e202402771.64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008209107"},{"key":"2024110107452488000_7.11.e202402771.65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.2.E344"},{"key":"2024110107452488000_7.11.e202402771.66","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24788-0"},{"key":"2024110107452488000_7.11.e202402771.67","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2017.1295898"},{"key":"2024110107452488000_7.11.e202402771.68","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1701"},{"key":"2024110107452488000_7.11.e202402771.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2006.11.005"},{"key":"2024110107452488000_7.11.e202402771.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44384-8"},{"key":"2024110107452488000_7.11.e202402771.71","unstructured":"R Core Team (2019) R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing."},{"key":"2024110107452488000_7.11.e202402771.72","doi-asserted-by":"publisher","DOI":"10.1002\/9780470942390.mo130043"},{"key":"2024110107452488000_7.11.e202402771.73","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1550055"},{"key":"2024110107452488000_7.11.e202402771.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.033"},{"key":"2024110107452488000_7.11.e202402771.75","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142241"},{"key":"2024110107452488000_7.11.e202402771.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.06.019"},{"key":"2024110107452488000_7.11.e202402771.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.07.034"},{"key":"2024110107452488000_7.11.e202402771.78","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2017.13"},{"key":"2024110107452488000_7.11.e202402771.79","doi-asserted-by":"publisher","DOI":"10.1242\/dev.199853"},{"key":"2024110107452488000_7.11.e202402771.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.11.003"},{"key":"2024110107452488000_7.11.e202402771.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.034"},{"key":"2024110107452488000_7.11.e202402771.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.005"},{"key":"2024110107452488000_7.11.e202402771.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.013"},{"key":"2024110107452488000_7.11.e202402771.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101696"},{"key":"2024110107452488000_7.11.e202402771.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"2024110107452488000_7.11.e202402771.86","doi-asserted-by":"publisher","DOI":"10.1101\/gr.772403"},{"key":"2024110107452488000_7.11.e202402771.87","doi-asserted-by":"publisher","DOI":"10.1038\/nature08894"},{"key":"2024110107452488000_7.11.e202402771.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.03.003"},{"key":"2024110107452488000_7.11.e202402771.89","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.016"},{"key":"2024110107452488000_7.11.e202402771.90","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.52"},{"key":"2024110107452488000_7.11.e202402771.91","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.002"},{"key":"2024110107452488000_7.11.e202402771.92","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0121"},{"key":"2024110107452488000_7.11.e202402771.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.01.003"},{"key":"2024110107452488000_7.11.e202402771.94","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.048"},{"key":"2024110107452488000_7.11.e202402771.95","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0249-y"},{"key":"2024110107452488000_7.11.e202402771.96","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"2024110107452488000_7.11.e202402771.97","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.09.570903"},{"key":"2024110107452488000_7.11.e202402771.98","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66323"},{"key":"2024110107452488000_7.11.e202402771.99","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.015"},{"key":"2024110107452488000_7.11.e202402771.100","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03851"},{"key":"2024110107452488000_7.11.e202402771.101","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117911"},{"key":"2024110107452488000_7.11.e202402771.102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.014"},{"key":"2024110107452488000_7.11.e202402771.103","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.12.005"},{"key":"2024110107452488000_7.11.e202402771.104","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55351-z"},{"key":"2024110107452488000_7.11.e202402771.105","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00364-0"}],"container-title":["Life Science Alliance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.26508\/lsa.202402771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T10:45:39Z","timestamp":1730457939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.life-science-alliance.org\/lookup\/doi\/10.26508\/lsa.202402771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":105,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,8,19]]},"published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.26508\/lsa.202402771"],"URL":"https:\/\/doi.org\/10.26508\/lsa.202402771","relation":{},"ISSN":["2575-1077"],"issn-type":[{"value":"2575-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]}}}