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Therapeutically, ouabain ameliorated the severity of MSU-induced gouty arthritis and LPS-induced lung injury in mice by inhibiting leukocyte infiltration. Overall, lysosomes facilitate the interaction between the Ragulator complex and MPRIP by supplying calcium ions through TRPML1 channels, thereby activating myosin IIA and promoting leukocyte migration.<\/jats:p>","DOI":"10.26508\/lsa.202403015","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T10:30:12Z","timestamp":1749551412000},"page":"e202403015","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["The Ragulator complex and lysosomal calcium release are crucial for cell migration"],"prefix":"10.26508","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-3723","authenticated-orcid":true,"given":"Tatsunori","family":"Jo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/035t8zc32","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka 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