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Alliance"],"accepted":{"date-parts":[[2025,3,18]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>B cells display several immunoregulatory mechanisms including the production of interleukin-10. Ectonucleotidases like CD39 and CD73 influence immune homeostasis by metabolizing eATP and generating immunosuppressive adenosine. The major objective was to examine the expression of those immunoregulatory molecules on B-cell subsets, and, more specifically, to determine their association with an infliximab (IFX) treatment in a pediatric inflammatory bowel disease (IBD) cohort. 42 IBD patients were assessed for IFX response after 12 mo of therapy and compared against 14 healthy controls (HC). Although IL10-producing plasmablasts were decreased in IFX nonresponders (NRS), we detected an up-regulation of CD39 on plasmablasts and increased fractions of CD39\/CD73-co-expressing na\u00efve and memory B cells in responding patients (RS). In addition, B cells of responders proved to have superior ATP degradation capacities and adenosine production before therapy initiation compared with NRS and HC. Moreover, IFX nonresponders had a marked deficiency of \u03b14\u03b27hi plasmablasts, whereas both cohorts had fewer CCR9-expressing plasmablasts. Consequently, CD39<jats:sup>+<\/jats:sup>plasmablasts were decreased in biopsies of inflamed mucosal tissues, especially in IFX nonresponders. Our results highlight the regulatory potential of CD39\/CD73-expressing B cells in pediatric IBD and suggest CD39<jats:sup>+<\/jats:sup>plasmablasts as a potential determinant of a successful immunosuppressive therapy with IFX.<\/jats:p>","DOI":"10.26508\/lsa.202403055","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T18:00:40Z","timestamp":1744135240000},"page":"e202403055","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Adenosine-generating CD39<sup>+<\/sup>plasmablasts predispose to successful infliximab therapy in pediatric IBD"],"prefix":"10.26508","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-7181","authenticated-orcid":true,"given":"Alexander","family":"Schnell","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, 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