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However, unresolved stress leads to apoptosis. In ALS, UPR activation fails to resolve proteostasis impairment. UPR activation modulators, among them Sephin1, reduce protein aggregates and improve motor neuron survival in ALS models. We demonstrate that following glutamate intoxication, Sephin1 increases motor neuron survival by reducing mitochondria ROS production and extranuclear TDP-43. Sephin1 reduces abnormal splicing because of TDP-43 nuclear loss of function following oxidative stress. In SOD1\n                    <jats:sup>G93A<\/jats:sup>\n                    mice, Sephin1 treatment decreases TDP-43 in triton-insoluble fraction, improving motor neuron survival in spinal cord. Sephin1 improves motor neurons survival, motor function and survival of mutated TDP-43 transgenic zebrafish. Sephin1 improves motor neuron survival in ALS models by reducing TDP-43 cytoplasmic mislocalization and its toxicity. These findings open new therapeutic opportunities for Sephin1 in neurodegenerative pathologies with TDP-43 proteinopathy, including ALS.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202403195","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T12:00:32Z","timestamp":1751457632000},"page":"e202403195","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models"],"prefix":"10.26508","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1270-1336","authenticated-orcid":true,"given":"Emmanuelle","family":"Abgueguen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/025mn7712","id-type":"ROR","asserted-by":"publisher"}],"name":"InFlectis BioScience","place":[", Nantes, 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