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Glycolysis is essential for tunneling nanotubes formation, which facilitates viral transfer and cell-to-cell fusion. Importantly, HIF-1\u03b1 activation contributes to these processes. Overall, these data might facilitate the development of targeted therapies aimed at inhibiting HIF-1\u03b1\u2013dependent glycolytic activity in TB-induced immunomodulatory macrophages to ultimately halt HIV-1 dissemination in coinfected patients.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202503333","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:21:33Z","timestamp":1770448893000},"page":"e202503333","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Glycolysis inhibition in tuberculosis-driven metabolic rewiring reduces HIV-1 spread in macrophages"],"prefix":"10.26508","volume":"9","author":[{"given":"Zo\u00ef","family":"Vahlas","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016zvc994","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut de Pharmacologie et de Biologie Structurale","place":["(IPBS), Universit\u00e9 de Toulouse, CNRS, 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