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Alliance"],"accepted":{"date-parts":[[2025,5,21]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Animals store oocytes in a dormant state for weeks to decades before ovulation. The homeostatic programs that oocytes use to endure long-term storage are poorly understood. Using female nematodes as a short-lived model, we found that oocyte formation and storage required IFET-1, the conserved eIF4E-transporter protein (eIF4ET). IFET-1 co-assembled with CAR-1 (Lsm14) to form micron-scale condensates in stored oocytes, which dissipated after oocyte activation. Depletion of IFET-1 destabilized the stored oocyte proteome, leading to lower translation, a decline in microtubule maintenance proteins, and errors in microtubule organization and meiotic spindle assembly. Deleting domains within IFET-1 impaired oocyte storage without affecting oocyte formation. Thus, in addition to establishing a healthy oocyte reserve in young mothers, IFET-1 ensures that correct levels of cytoskeletal proteins are maintained as oocytes age. eIF4ET also localized to micron-scale puncta in dormant human oocytes. Our results clarify how eIF4ET maintains the oocyte reserve and further support eIF4ET dysfunction as an upstream cause of embryonic aneuploidy and age-related infertility.<\/jats:p>","DOI":"10.26508\/lsa.202503387","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T18:35:18Z","timestamp":1748543718000},"page":"e202503387","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage"],"prefix":"10.26508","volume":"8","author":[{"given":"Priyankaa","family":"Bhatia","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, 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