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A\u03b242 fibrils inhibited CTB syncytialization, a critical step in maintaining pregnancy, by inducing loss of membrane localization of cell\u2013cell adhesion molecules. Primary human CTBs confirmed these observations. Taken together, our results suggest that increased A\u03b2 production in CTBs by hypoxia may lead to the formation of A\u03b2 fibrils, which inhibit syncytiotrophoblast formation and are detrimental to pregnancy. 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